Monomethyl Fumarate

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Monomethyl Fumarate Brand Name– BAFIERTAM

What is Monomethyl Fumarate

Monomethyl fumarate (MMF) is indicated for the treatment of adults with relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.

Like dimethyl fumarate, MMF exhibits neuroprotective and anti-inflammatory properties; these actions can help delay disability and disease progression.

Monomethyl fumarate is expected to have better gastrointestinal tolerability when compared to dimethyl fumarate.

Monomethyl fumarate received FDA approval in April 2020.

Indications

  • multiple sclerosis

For the treatment of relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. angioedema
  4. diarrhea
  5. dyspepsia
  6. elevated hepatic enzymes
  7. eosinophilia
  8. erythema
  9. flushing
  10. infection
  11. leukoencephalopathy
  12. leukopenia
  13. lymphopenia
  14. lymphopenia
  15. nausea
  16. progressive multifocal leukoencephalopathy
  17. proteinuria
  18. pruritus
  19. rash
  20. urticaria
  21. vomiting

Monitoring Parameters

  • CBC with differential
  • LFTs
  • neurologic function
  • serum bilirubin

Contraindications

  • breast-feeding
  • hepatic disease
  • hepatotoxicity
  • immunosuppression
  • pregnancy
  • progressive multifocal leukoencephalopathy

Interactions

  • Dimethyl Fumarate
  • Diroximel Fumarate
  • Ocrelizumab
  • Ozanimod

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What is recurrence

What is recurrence?  Recurrence refers to an initial reduction in...

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