Mitomycin Brand Name– JELMYTO | Mitosol | Mutamycin
What is Mitomycin
Mitomycin is an antitumor antibiotic that acts as an alkylating agent and is derived from Streptomyces caespitosus.
It is indicated intravenously for the treatment of metastatic stomach or pancreatic cancer in proven combinations with other chemotherapeutic agents.
An ophthalmic solution is indicated as a topical adjunct to ab externo glaucoma surgery; this formulation is not intended for intraocular administration.
Finally, a pyelocalyceal solution is indicated for the treatment of patients with low-grade upper tract urothelial cancer (LG-UTUC); this formulation appears as a semisolid gel at room temperature and must be chilled to become a viscous liquid for administration.
Mitomycin can be associated neutropenia and thrombocytopenia; an interruption of therapy or discontinuation of therapy may be necessary if myelosuppression occurs.
Indications
- anal cancer
- biliary tract cancer
- bladder cancer
- cervical cancer
- colorectal cancer
- gastric cancer
- glaucoma
- head and neck cancer
- mesothelioma
- ocular surgery
- pancreatic cancer
- urothelial carcinoma
Side Effects
- acute respiratory distress syndrome (ARDS)
- alopecia
- anemia
- anorexia
- asthenia
- blurred vision
- bone marrow suppression
- bronchospasm
- cataracts
- confusion
- cough
- cystitis
- diarrhea
- drowsiness
- dyspnea
- dysuria
- edema
- endophthalmitis
- erythema
- fatigue
- fever
- headache
- heart failure
- hematemesis
- hematuria
- hemolysis
- hemolytic anemia
- hemolytic-uremic syndrome
- hypertension
- hyphema
- increased urinary frequency
- infection
- injection site reaction
- iritis
- keratitis
- leukopenia
- macular edema
- malaise
- nausea
- ocular hemorrhage
- ocular hypotonia
- papilledema
- phlebitis
- pulmonary edema
- rash
- renal failure (unspecified)
- retinal detachment
- retinal hemorrhage
- skin ulcer
- stomatitis
- syncope
- thrombocytopenia
- tissue necrosis
- urinary urgency
- visual impairment
- vomiting
- wound dehiscence
Monitoring Parameters
- CBC with differential
- pregnancy testing
- serum creatinine/BUN
Contraindications
- accidental exposure
- acute bronchospasm
- anemia
- bleeding
- bone marrow suppression
- breast-feeding
- children
- coagulopathy
- dental disease
- dental work
- extravasation
- hemolytic-uremic syndrome
- herpes infection
- infants
- infection
- infertility
- intramuscular administration
- intramuscular injections
- leukopenia
- male-mediated teratogenicity
- neutropenia
- ocular exposure
- pregnancy
- pulmonary disease
- pulmonary fibrosis
- radiation therapy
- renal failure
- renal impairment
- requires a specialized care setting
- requires an experienced clinician
- respiratory insufficiency
- subcutaneous administration
- surgery
- thrombocytopenia
- vaccination
- varicella
- viral infection
Mitomycin is contraindicated in patients with a history of hypersensitivity reactions or idiosyncratic reactions to the drug.
Interactions
- Alpha interferons
- Amlodipine; Celecoxib
- Antithymocyte Globulin
- Atazanavir; Cobicistat
- Azelastine; Fluticasone
- Bacillus Calmette-Guerin Vaccine, BCG
- Beclomethasone
- Betamethasone
- Boceprevir
- Budesonide
- Budesonide; Formoterol
- Cabozantinib
- Carbamazepine
- Carvedilol
- Celecoxib
- Ciclesonide
- Clozapine
- Cobicistat
- Conivaptan
- Corticosteroids
- Cortisone
- Daclatasvir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Dexamethasone
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Echinacea
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Esomeprazole; Naproxen
- Etodolac
- Etravirine
- Famotidine; Ibuprofen
- Febuxostat
- Fenoprofen
- Flucytosine
- Fludrocortisone
- Flunisolide
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Fosamprenavir
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Influenza Virus Vaccine
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Intranasal Influenza Vaccine
- Ixabepilone
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Ledipasvir; Sofosbuvir
- Live Vaccines
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Methylprednisolone
- Mometasone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Ombitasvir; Paritaprevir; Ritonavir
- Oxaprozin
- Palifermin
- Pegfilgrastim
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Penicillamine
- Piroxicam
- Posaconazole
- Prednisolone
- Prednisone
- Ritonavir
- Rofecoxib
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Sapropterin
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sulindac
- Telaprevir
- Telithromycin
- Temsirolimus
- Tolmetin
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Typhoid Vaccine
- Valdecoxib
- Varicella-Zoster Virus Vaccine, Live
- Vemurafenib
- Vinblastine
- Vinca alkaloids
- Vincristine
- Vincristine Liposomal
- Vinorelbine
- Yellow Fever Vaccine, Live
- Zonisamide
