Mitotane Brand Name– Lysodren
What is Mitotane
Mitotane is an adrenocortical cytotoxic antineoplastic agent that is structurally related to the insecticide chlorophenothane (DDT).
It is used almost exclusively for adrenocortical carcinoma but also could be useful in Cushing’s disease.
It appears to act by impairing steroid synthesis, which in turn causes adrenal atrophy.
Mitotane was approved by the FDA in 1970.
Indications
- adrenocortical cancer
- Cushing’s syndrome
For the treatment of inoperable adrenocortical cancer, both functional and non-functional types
Side Effects
- adrenocortical insufficiency
- anorexia
- arthralgia
- ataxia
- blurred vision
- confusion
- depression
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysarthria
- elevated hepatic enzymes
- fever
- flushing
- growth inhibition
- gynecomastia
- headache
- hematuria
- hemorrhagic cystitis
- hepatitis
- hypercholesterolemia
- hypertension
- hypertriglyceridemia
- hypothyroidism
- lethargy
- myalgia
- nausea
- neutropenia
- orthostatic hypotension
- pelvic pain
- proteinuria
- rash
- retinopathy
- vaginal bleeding
- vertigo
- vomiting
- weakness
Monitoring Parameters
- neurologic function
- serum cortisol
Contraindications
- adrenal insufficiency
- breast-feeding
- contraception requirements
- driving or operating machinery
- infection
- neurotoxicity
- ovarian cyst
- pregnancy
- reproductive risk
- shock
- surgery
- trauma
- vaginal bleeding
Mitotane therapy should not be given to individuals who have demonstrated a previous hypersensitivity to mitotane
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Abiraterone
- Acalabrutinib
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alosetron
- Alpelisib
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
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- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apremilast
- Aprepitant, Fosaprepitant
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- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir
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