Mineralocorticoid Properties of Glucocorticoid Preparations

Which group of corticosteroid medications results in the least amount of sodium retention?

Sodium retention is dependent upon the mineralocorticoid effect of the preparation. It is insignificant in the usual doses of methylprednisolone, triamcinolone, paramethasone, betamethasone, and dexamethasone

Mineralocorticoid Properties of Glucocorticoid Preparations

GlucocorticoidMineralocorticoid Potency a
Short-acting
Hydrocortisone (cortisol)1
Cortisone0.8
Intermediate-acting
Prednisone0.25
Prednisolone0.25
Methylprednisolone±
Triamcinolone±
Long-acting
Paramethasone±
Betamethasone±
Dexamethasone±

a Potency is expressed in milligram compared with cortisol reference value of 1.

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