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Which group of corticosteroid medications results in the least amount of sodium retention?
Sodium retention is dependent upon the mineralocorticoid effect of the preparation. It is insignificant in the usual doses of methylprednisolone, triamcinolone, paramethasone, betamethasone, and dexamethasone
Mineralocorticoid Properties of Glucocorticoid Preparations
| Glucocorticoid | Mineralocorticoid Potency a |
|---|---|
| Short-acting | |
| Hydrocortisone (cortisol) | 1 |
| Cortisone | 0.8 |
| Intermediate-acting | |
| Prednisone | 0.25 |
| Prednisolone | 0.25 |
| Methylprednisolone | ± |
| Triamcinolone | ± |
| Long-acting | |
| Paramethasone | ± |
| Betamethasone | ± |
| Dexamethasone | ± |
a Potency is expressed in milligram compared with cortisol reference value of 1.
