Metyrapone

Metyrapone Brand Name– Metopirone

What is Metyrapone

Metyrapone is an oral diagnostic agent that inhibits steroidogenesis.

Specifically, metyrapone works by inhibiting endogenous adrenal corticosteroid synthesis, thus decreasing the production of cortisol and corticosterone.

Metyrapone is utilized to evaluate hypothalamic-pituitary ACTH function; the two regimens approved for use are a single-dose overnight regimen and a multiple dose regimen administered over 24 hours.

In children with asthma receiving inhaled corticosteroids, it has been suggested that the overnight metyrapone test will detect abnormalities in adrenal function more often than other tests.

Metyrapone is also used off-label in the treatment of Cushing’s syndrome.

Metyrapone was approved by the FDA in 1961.

Indications

  • Cushing’s syndrome
  • hypothalamic-pituitary-adrenal (HPA) suppression diagnosis

For hypothalamic-pituitary-adrenal (HPA) suppression diagnosis

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. adrenocortical insufficiency
  4. ataxia
  5. dizziness
  6. drowsiness
  7. edema
  8. headache
  9. hirsutism
  10. hypertension
  11. hypotension
  12. lethargy
  13. leukopenia
  14. nausea
  15. rash
  16. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • adrenal insufficiency
  • breast-feeding
  • corticosteroid therapy
  • driving or operating machinery
  • hyperthyroidism
  • hypothyroidism
  • pregnancy

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