Metyrosine

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Metyrosine Brand Name– Demser

What is Metyrosine

Metyrosine is an orally administered agent used to inhibit catecholamine synthesis in patients with pheochromocytoma, a chromaffin cell tumor that produces excessive amounts of epinephrine and norepinephrine.

Metyrosine can be useful in patients who are refractory to phenoxybenzamine therapy, or it can be administered as an adjunct to phenoxybenzamine therapy.

Metyrosine also has been used to treat essential hypertension, but other more useful agents preclude its use.

Metyrosine was approved by the FDA in 1979.

Indications

  • pheochromocytoma

For the short-term management of patients with pheochromocytoma who are awaiting surgery, or for long-term management of malignant pheochromocytoma when surgery is contraindicated

Side Effects

  1. abdominal pain
  2. anemia
  3. anxiety
  4. confusion
  5. crystalluria
  6. depression
  7. diarrhea
  8. drowsiness
  9. dysarthria
  10. dysuria
  11. eosinophilia
  12. fatigue
  13. galactorrhea
  14. hallucinations
  15. headache
  16. hematuria
  17. hypersalivation
  18. impotence (erectile dysfunction)
  19. nasal congestion
  20. nausea
  21. peripheral edema
  22. thrombocytopenia
  23. thrombocytosis
  24. tremor
  25. trismus
  26. urticaria
  27. vomiting
  28. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • dehydration
  • driving or operating machinery
  • hepatic disease
  • Parkinson’s disease
  • pregnancy
  • renal disease
  • surgery

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Amobarbital
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benzodiazepines
  • Butabarbital
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Chlorpromazine
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Dextromethorphan; Promethazine
  • Ethanol
  • Fluphenazine
  • Haloperidol
  • Levodopa
  • Meperidine; Promethazine
  • Mephobarbital
  • Mesoridazine
  • Methohexital
  • Metoclopramide
  • Molindone
  • Opiate Agonists
  • Pentobarbital
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phenothiazines
  • Phenylephrine; Promethazine
  • Primidone
  • Prochlorperazine
  • Promethazine
  • Secobarbital
  • Sedating H1-blockers
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Tricyclic antidepressants
  • Trifluoperazine

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