Methocarbamol

Methocarbamol Brand Name– Robaxin

What is Methocarbamol

Methocarbamol is an oral and parenteral, central nervous system depressant with sedative and musculoskeletal relaxant properties.

Methocarbamol is used as adjunct therapy for acute, painful musculoskeletal conditions and in the management of tetanus; it is not indicated for spasticity.

This drug was first marketed in the U.S. in 1957. Despite decades of use, there are little published data of sufficient quality to demonstrate efficacy of methocarbamol vs. placebo or comparator drugs for musculoskeletal conditions.

Indications

  • musculoskeletal pain
  • tetanus

For use as an adjunct to rest, physical therapy, and other measures for the relief of musculoskeletal pain associated with acute, painful musculoskeletal conditions

Side Effects

  1. amnesia
  2. anaphylactoid reactions
  3. angioedema
  4. blurred vision
  5. bradycardia
  6. confusion
  7. conjunctivitis
  8. diplopia
  9. dizziness
  10. drowsiness
  11. dyspepsia
  12. fever
  13. flushing
  14. headache
  15. hemolysis
  16. hypotension
  17. injection site reaction
  18. insomnia
  19. jaundice
  20. leukopenia
  21. metallic taste
  22. nasal congestion
  23. nausea
  24. nystagmus
  25. phlebitis
  26. pruritus
  27. rash
  28. seizures
  29. syncope
  30. urine discoloration
  31. urticaria
  32. vertigo
  33. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • coadministration with other CNS depressants
  • driving or operating machinery
  • ethanol ingestion
  • extravasation
  • geriatric
  • hepatic disease
  • history of angioedema
  • hypotension
  • infants
  • laboratory test interference
  • neonates
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder

Methocarbamol is contraindicated for use by patients hypersensitive to methocarbamol or to any component of the formulation, such as a history of angioedema or anaphylactic reaction to methocarbamol.

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Tramadol
  • Alfentanil
  • Alprazolam
  • Ambenonium Chloride
  • Amitriptyline; Chlordiazepoxide
  • Amobarbital
  • Anxiolytics; Sedatives; and Hypnotics
  • Apomorphine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Butabarbital
  • Butorphanol
  • Cannabidiol
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cenobamate
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Cholinesterase inhibitors
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Deutetrabenazine
  • Dexmedetomidine
  • Dextromethorphan; Promethazine
  • Diazepam
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Donepezil
  • Donepezil; Memantine
  • Dronabinol
  • Droperidol
  • Edrophonium
  • Esketamine
  • Estazolam
  • Ethanol
  • Fenfluramine
  • Fentanyl
  • Fluphenazine
  • Flurazepam
  • Gabapentin
  • Galantamine
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Ketamine
  • Lasmiditan
  • Lemborexant
  • Levorphanol
  • Lofexidine
  • Lorazepam
  • Lumateperone
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Mesoridazine
  • Methadone
  • Methohexital
  • Methscopolamine
  • Metyrapone
  • Midazolam
  • Molindone
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Neostigmine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phenothiazines
  • Phenylephrine; Promethazine
  • Physostigmine
  • Pregabalin
  • Primidone
  • Prochlorperazine
  • Promethazine
  • Pyridostigmine
  • Quazepam
  • Remifentanil
  • Rivastigmine
  • Secobarbital
  • Sedating H1-blockers
  • Sufentanil
  • Tacrine
  • Tapentadol
  • Temazepam
  • Thalidomide
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Tramadol
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Ziconotide
  • Ziprasidone