Mefenamic Acid Brand Name– Ponstel
What is Mefenamic Acid
Mefenamic acid is a member of the anthranilic acid (fenamate) group of nonsteroidal anti-inflammatory drugs (NSAIDs); meclofenamate sodium is also a member of the fenamate class of NSAIDs.
Mefenamic acid is used in the treatment of mild to moderate pain including dysmenorrhea and arthritis.
Like other NSAIDs, mefenamic acid causes an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke.
The lowest effective dose for the shortest possible duration is recommended, as the risk for adverse effects may increase with duration of use.
Indications
- dysmenorrhea
- migraine
- migraine prophylaxis
- mild pain
- moderate pain
For the treatment of dysmenorrhea
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- anxiety
- aplastic anemia
- appetite stimulation
- arrhythmia exacerbation
- aseptic meningitis
- asthenia
- blurred vision
- bullous rash
- coma
- confusion
- conjunctivitis
- constipation
- cystitis
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- dysphagia
- dyspnea
- dysuria
- ecchymosis
- edema
- elevated hepatic enzymes
- eosinophilia
- eructation
- erythema multiforme
- esophageal stricture
- esophageal ulceration
- esophagitis
- exfoliative dermatitis
- fever
- flatulence
- gastritis
- GI bleeding
- GI perforation
- glossitis
- hallucinations
- headache
- hearing loss
- heart failure
- hematemesis
- hematuria
- hemolytic anemia
- hepatic failure
- hepatitis
- hyperglycemia
- hypertension
- hypotension
- infection
- insomnia
- interstitial nephritis
- jaundice
- leukopenia
- lymphadenopathy
- malaise
- melena
- myocardial infarction
- nausea
- nephrotic syndrome
- odynophagia
- oliguria
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- peptic ulcer
- photosensitivity
- platelet dysfunction
- polyuria
- proteinuria
- pruritus
- purpura
- pyrosis (heartburn)
- rash
- renal failure (unspecified)
- renal papillary necrosis
- respiratory depression
- seizures
- sinus tachycardia
- Stevens-Johnson syndrome
- stomatitis
- stroke
- syncope
- thrombocytopenia
- thromboembolism
- tinnitus
- toxic epidermal necrolysis
- tremor
- urticaria
- vasculitis
- vertigo
- vomiting
- weight gain
- weight loss
- xerostomia
Monitoring Parameters
- CBC
- LFTs
- serum creatinine/BUN
- stool guaiac
Contraindications
- acute bronchospasm
- acute myocardial infarction
- alcoholism
- anemia
- angina
- anticoagulant therapy
- asthma
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- cerebrovascular disease
- chemotherapy
- children
- coagulopathy
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- corticosteroid therapy
- dehydration
- diabetes mellitus
- geriatric
- GI bleeding
- GI disease
- GI perforation
- heart failure
- hematological disease
- hemophilia
- hepatic disease
- hypertension
- hypoalbuminemia
- hypovolemia
- immunosuppression
- infants
- intracranial bleeding
- intramuscular injections
- jaundice
- labor
- lactase deficiency
- myocardial infarction
- nasal polyps
- neonates
- neutropenia
- NSAID hypersensitivity
- obstetric delivery
- peptic ulcer disease
- peripheral vascular disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- rheumatoid arthritis
- salicylate hypersensitivity
- stroke
- surgery
- systemic lupus erythematosus (SLE)
- tachycardia
- thrombocytopenia
- thromboembolism
- tobacco smoking
- ulcerative colitis
- urticaria
Interactions
- Abciximab
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
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- Aminolevulinic Acid
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- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
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