Mefloquine Brand Name– Lariam
What is Mefloquine
Mefloquine is an oral antimalarial agent. It is used for malaria prophylaxis or for treatment of susceptible strains of malaria.
Prophylactic dosing should begin 1 week before entering endemic area and continue for 4 weeks after leaving.
Due to the existance of chloroquine- and proguanil-resistant strains of malaria, mefloquine has been used as an alternative antimalarial, especially in European countries.
Mefloquine was approved by the FDA in 1989 and is the treatment of choice for malaria in the United States.
Indications
- malaria
- malaria prophylaxis
- Plasmodium falciparum
- Plasmodium vivax
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- agranulocytosis
- alopecia
- anxiety
- aplastic anemia
- arthralgia
- asthenia
- ataxia
- AV block
- bradycardia
- chest pain (unspecified)
- chills
- confusion
- depression
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- dyspnea
- edema
- elevated hepatic enzymes
- emotional lability
- encephalopathy
- erythema multiforme
- fatigue
- fever
- flushing
- hallucinations
- headache
- hearing loss
- hepatic failure
- hyperhidrosis
- hypertension
- hypotension
- insomnia
- leukocytosis
- malaise
- memory impairment
- muscle cramps
- myalgia
- nausea
- palpitations
- paranoia
- paresthesias
- pneumonitis
- PR prolongation
- pruritus
- psychosis
- QT prolongation
- rash
- restlessness
- seizures
- sinus tachycardia
- Stevens-Johnson syndrome
- suicidal ideation
- syncope
- thrombocytopenia
- tinnitus
- tremor
- urticaria
- vertigo
- visual impairment
- vomiting
- weakness
Monitoring Parameters
- CBC
- ophthalmologic exam
Contraindications
- anxiety
- apheresis
- AV block
- behavioral changes
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- depression
- driving or operating machinery
- females
- fever
- geriatric
- heart failure
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- long QT syndrome
- mefloquine hypersensitivity
- myocardial infarction
- neurologic events
- ocular disease
- pheochromocytoma
- pregnancy
- psychiatric event
- psychosis
- QT prolongation
- quinidine hypersensitivity
- quinine hypersensitivity
- rheumatoid arthritis
- schizophrenia
- seizure disorder
- seizures
- sickle cell disease
- sleep deprivation
- stroke
- suicidal ideation
- systemic lupus erythematosus (SLE)
- tinnitus
Interactions
- Abarelix
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Aclidinium; Formoterol
- Afatinib
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anagrelide
- Antacids
- Anticonvulsants
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
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- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Bepridil
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- Betaxolol
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- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
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