Medroxyprogesterone Brand Names
Amen | Depo-Provera | Depo-subQ Provera 104 | Provera
What is Medroxyprogesterone
Medroxyprogesterone is an oral and parenteral synthetic progestin that is 15 times more potent than progesterone.
Medroxyprogesterone can be used for the treatment of amenorrhea, abnormal uterine bleeding, hot flashes, endometriosis secondary to hormonal imbalances, and endometrial and renal cell carcinomas.
The IM injection is a sustained-release (i.e., ‘depo’) product available in 2 dosage strengths: one for use as a contraceptive and the other for the treatment of endometrial and renal cell carcinoma.
Medroxyprogesterone may be useful as respiratory stimulants in certain pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Investigational agents containing medroxyprogesterone are also under development.
InKine Pharmaceutical Co. is developing Colirest, a proprietary form of medroxyprogesterone, as a treatment for patients with Crohn’s disease, ulcerative colitis, and other inflammatory bowel disorders.
The drug may have applicability in these diseases because medroxyprogesterone inhibits pro-inflammatory mediators such as interleukin-6 and tumour necrosis factor (TNF), and thus offers an alternative to steroids and other available treatments.
A phase III placebo-controlled trial is underway for the treatment of Crohn’s disease; other studies are in progress for ulcerative colitis.
Medroxyprogesterone was originally approved by the FDA in 1959.
Indications
- amenorrhea
- andropause
- contraception
- dysfunctional uterine bleeding
- endometrial cancer
- endometriosis
- estrogen replacement therapy
- hot flashes
- hyperparathyroidism
- menopause
- paraphilia
- Pickwickian syndrome
- renal cell cancer
For the treatment of secondary amenorrhea
Side Effects
- abdominal pain
- acne vulgaris
- alopecia
- amenorrhea
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- anovulation
- anxiety
- appetite stimulation
- arthralgia
- asthenia
- back pain
- bone fractures
- breakthrough bleeding
- breast cancer
- breast discharge
- breast enlargement
- cervical dysplasia
- chills
- cholestasis
- cystitis
- dementia
- depression
- diarrhea
- dizziness
- drowsiness
- dysmenorrhea
- dyspareunia
- edema
- emotional lability
- endometrial cancer
- endometrial hyperplasia
- euphoria
- fatigue
- fever
- fluid retention
- galactorrhea
- GI bleeding
- headache
- hirsutism
- hot flashes
- hyperbilirubinemia
- hypercalcemia
- hyperglycemia
- hyperhidrosis
- impaired cognition
- impotence (erectile dysfunction)
- infertility
- injection site reaction
- insomnia
- irritability
- jaundice
- leukorrhea
- libido decrease
- libido increase
- lipodystrophy
- malaise
- mastalgia
- melasma
- menorrhagia
- menstrual irregularity
- migraine
- muscle cramps
- myocardial infarction
- nausea
- new primary malignancy
- oligomenorrhea
- optic neuritis
- osteopenia
- osteoporosis
- ovarian cancer
- paresthesias
- pelvic pain
- phlebitis
- polydipsia
- porphyria
- postmenopausal bleeding
- pruritus
- pulmonary embolism
- rash
- retinal thrombosis
- seizures
- sinus tachycardia
- skin atrophy
- skin discoloration
- stroke
- syncope
- thromboembolism
- thrombosis
- urticaria
- vaginal bleeding
- vaginitis
- weight gain
- weight loss
- xerosis
Monitoring Parameters
- pap smear
- pelvic exam
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- alcoholism
- anorexia nervosa
- asthma
- breast cancer
- breast-feeding
- cerebrovascular disease
- cervical cancer
- children
- cholestasis
- coronary artery disease
- corticosteroid therapy
- dementia
- depression
- diabetes mellitus
- ectopic pregnancy
- endometrial cancer
- endometrial hyperplasia
- geriatric
- hepatic disease
- history of angioedema
- human immunodeficiency virus (HIV) infection
- hypercholesterolemia
- hyperlipidemia
- hypertension
- hypocalcemia
- incomplete abortion
- infants
- infertility
- intravenous administration
- jaundice
- menstrual irregularity
- migraine
- myocardial infarction
- neonates
- new primary malignancy
- obesity
- osteopenia
- osteoporosis
- ovarian cancer
- porphyria
- pregnancy
- renal disease
- seizure disorder
- sexually transmitted disease
- stroke
- systemic lupus erythematosus (SLE)
- thromboembolic disease
- thromboembolism
- thrombophlebitis
- tobacco smoking
- uterine cancer
- vaginal bleeding
- vaginal cancer
- visual disturbance
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetohexamide
- Acitretin
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Amobarbital
- Amprenavir
- Apalutamide
- Aprepitant, Fosaprepitant
- Armodafinil
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Brigatinib
- Bromocriptine
- Butabarbital
- Canagliflozin; Metformin
- Carbamazepine
- Cenobamate
- Ceritinib
- Chlorpropamide
- Clobazam
- Cobicistat
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enzalutamide
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Fedratinib
- Felbamate
- Fluvoxamine
- Fosamprenavir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- grapefruit juice
- Griseofulvin
- Hydantoins
- Idelalisib
- Incretin Mimetics
- Indinavir
- Insulins
- Isotretinoin
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lefamulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Linagliptin
- Linagliptin; Metformin
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Meglitinides
- Mephobarbital
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methohexital
- Mitotane
- Modafinil
- Nefazodone
- Nelfinavir
- Nevirapine
- Ombitasvir; Paritaprevir; Ritonavir
- Oxcarbazepine
- Pegvaliase
- Pentobarbital
- Phenobarbital
- Phentermine; Topiramate
- Posaconazole
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifamycins
- Ritonavir
- Saquinavir
- Saxagliptin
- Secobarbital
- Simvastatin; Sitagliptin
- Sitagliptin
- St. John’s Wort, Hypericum perforatum
- Sugammadex
- Sulfonylureas
- Tamoxifen
- Tazemetostat
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Thiopental
- Tipranavir
- Tolazamide
- Tolbutamide
- Topiramate
- Tucatinib
- Ulipristal
- Voriconazole
