Medroxyprogesterone

Medroxyprogesterone Brand Names

Amen | Depo-Provera | Depo-subQ Provera 104 | Provera

What is Medroxyprogesterone

Medroxyprogesterone is an oral and parenteral synthetic progestin that is 15 times more potent than progesterone.

Medroxyprogesterone can be used for the treatment of amenorrhea, abnormal uterine bleeding, hot flashes, endometriosis secondary to hormonal imbalances, and endometrial and renal cell carcinomas.

The IM injection is a sustained-release (i.e., ‘depo’) product available in 2 dosage strengths: one for use as a contraceptive and the other for the treatment of endometrial and renal cell carcinoma.

Medroxyprogesterone may be useful as respiratory stimulants in certain pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.

Investigational agents containing medroxyprogesterone are also under development.

InKine Pharmaceutical Co. is developing Colirest, a proprietary form of medroxyprogesterone, as a treatment for patients with Crohn’s disease, ulcerative colitis, and other inflammatory bowel disorders.

The drug may have applicability in these diseases because medroxyprogesterone inhibits pro-inflammatory mediators such as interleukin-6 and tumour necrosis factor (TNF), and thus offers an alternative to steroids and other available treatments.

A phase III placebo-controlled trial is underway for the treatment of Crohn’s disease; other studies are in progress for ulcerative colitis.

Medroxyprogesterone was originally approved by the FDA in 1959.

Indications

  1. amenorrhea
  2. andropause
  3. contraception
  4. dysfunctional uterine bleeding
  5. endometrial cancer
  6. endometriosis
  7. estrogen replacement therapy
  8. hot flashes
  9. hyperparathyroidism
  10. menopause
  11. paraphilia
  12. Pickwickian syndrome
  13. renal cell cancer

For the treatment of secondary amenorrhea

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. alopecia
  4. amenorrhea
  5. anaphylactic shock
  6. anaphylactoid reactions
  7. anemia
  8. angioedema
  9. anovulation
  10. anxiety
  11. appetite stimulation
  12. arthralgia
  13. asthenia
  14. back pain
  15. bone fractures
  16. breakthrough bleeding
  17. breast cancer
  18. breast discharge
  19. breast enlargement
  20. cervical dysplasia
  21. chills
  22. cholestasis
  23. cystitis
  24. dementia
  25. depression
  26. diarrhea
  27. dizziness
  28. drowsiness
  29. dysmenorrhea
  30. dyspareunia
  31. edema
  32. emotional lability
  33. endometrial cancer
  34. endometrial hyperplasia
  35. euphoria
  36. fatigue
  37. fever
  38. fluid retention
  39. galactorrhea
  40. GI bleeding
  41. headache
  42. hirsutism
  43. hot flashes
  44. hyperbilirubinemia
  45. hypercalcemia
  46. hyperglycemia
  47. hyperhidrosis
  48. impaired cognition
  49. impotence (erectile dysfunction)
  50. infertility
  51. injection site reaction
  52. insomnia
  53. irritability
  54. jaundice
  55. leukorrhea
  56. libido decrease
  57. libido increase
  58. lipodystrophy
  59. malaise
  60. mastalgia
  61. melasma
  62. menorrhagia
  63. menstrual irregularity
  64. migraine
  65. muscle cramps
  66. myocardial infarction
  67. nausea
  68. new primary malignancy
  69. oligomenorrhea
  70. optic neuritis
  71. osteopenia
  72. osteoporosis
  73. ovarian cancer
  74. paresthesias
  75. pelvic pain
  76. phlebitis
  77. polydipsia
  78. porphyria
  79. postmenopausal bleeding
  80. pruritus
  81. pulmonary embolism
  82. rash
  83. retinal thrombosis
  84. seizures
  85. sinus tachycardia
  86. skin atrophy
  87. skin discoloration
  88. stroke
  89. syncope
  90. thromboembolism
  91. thrombosis
  92. urticaria
  93. vaginal bleeding
  94. vaginitis
  95. weight gain
  96. weight loss
  97. xerosis

Monitoring Parameters

  • pap smear
  • pelvic exam

Contraindications

  • acquired immunodeficiency syndrome (AIDS)
  • alcoholism
  • anorexia nervosa
  • asthma
  • breast cancer
  • breast-feeding
  • cerebrovascular disease
  • cervical cancer
  • children
  • cholestasis
  • coronary artery disease
  • corticosteroid therapy
  • dementia
  • depression
  • diabetes mellitus
  • ectopic pregnancy
  • endometrial cancer
  • endometrial hyperplasia
  • geriatric
  • hepatic disease
  • history of angioedema
  • human immunodeficiency virus (HIV) infection
  • hypercholesterolemia
  • hyperlipidemia
  • hypertension
  • hypocalcemia
  • incomplete abortion
  • infants
  • infertility
  • intravenous administration
  • jaundice
  • menstrual irregularity
  • migraine
  • myocardial infarction
  • neonates
  • new primary malignancy
  • obesity
  • osteopenia
  • osteoporosis
  • ovarian cancer
  • porphyria
  • pregnancy
  • renal disease
  • seizure disorder
  • sexually transmitted disease
  • stroke
  • systemic lupus erythematosus (SLE)
  • thromboembolic disease
  • thromboembolism
  • thrombophlebitis
  • tobacco smoking
  • uterine cancer
  • vaginal bleeding
  • vaginal cancer
  • visual disturbance

Interactions

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