Magaldrate (hydromagnesium aluminate)

Magaldrate Brand Name– Lowsium | Ron-Acid

What is Magaldrate

Magaldrate (hydromagnesium aluminate) is an oral antacid. Magaldrate is a chemical entity of magnesium and aluminum oxides and sulfate; it is not just a physical mixture.

The suspension is composed of smaller particles, which provide a larger surface area and a more rapid and effective dissolution in gastric acid.

Magaldrate is used symptomatically for the relief of dyspepsia, hyperacidity associated with peptic ulcer, peptic esophagitis and hiatal hernia. The side effects of constipation from aluminum and diarrhea from magnesium are dose related, and the combination of both entities in one product allows for decreased GI adverse effects.

The combination of aluminum and magnesium also allows for a potent acid neutralizing capacity with lower doses of each agent.

Magaldrate is commercially available in an oral suspension and may also be combined with the defoaming agent simethicone to reduce gas in the stomach; several magaldrate-containing combination antacids are also marketed.

Indications

  1. duodenal ulcer
  2. dyspepsia
  3. gastric ulcer
  4. gastroesophageal reflux disease (GERD)
  5. pyrosis (heartburn)
  6. stress gastritis prophylaxis

For symptomatic relief of dyspepsia, pyrosis (heartburn), or conditions associated with hyperacidity [e.g., adjunctive therapy of hypersecretory conditions like gastric ulcer†; duodenal ulcer†, gastroesophageal reflux disease (GERD)

Side Effects

  1. anorexia
  2. confusion
  3. constipation
  4. dehydration
  5. diarrhea
  6. diuresis
  7. encephalopathy
  8. GI obstruction
  9. hemorrhoids
  10. hypercalcemia
  11. hypermagnesemia
  12. hypophosphatemia
  13. hyporeflexia
  14. hypotension
  15. impaired cognition
  16. malaise
  17. nausea
  18. nephrolithiasis
  19. osteomalacia
  20. osteoporosis
  21. vomiting
  22. weakness

Monitoring Parameters

  • serum magnesium

Contraindications

  • appendicitis
  • benzyl alcohol hypersensitivity
  • biliary cirrhosis
  • breast-feeding
  • children
  • colostomy
  • dialysis
  • diverticulitis
  • geriatric
  • GI bleeding
  • GI obstruction
  • heart failure
  • hypermagnesemia
  • hypertension
  • hypophosphatemia
  • ileostomy
  • infants
  • neonates
  • osteomalacia
  • peripheral edema
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • sodium restriction
  • ulcerative colitis

Interactions

There are no drug interactions associated with Magaldrate products.