Magnesium Citrate

Magnesium Citrate Brand Name– Citroma

What is Magnesium Citrate

Magnesium citrate is a hyperosmotic saline laxative given orally as a bowel preparation prior to intestinal surgery/procedures or for intermittent relief of constipation.

Magnesium citrate acts by osmotically drawing water into the intestinal lumen; the intestine then responds to the increase in volume with increased peristalsis and release of cholecystokinin.

The onset of laxative effect is short (30 minutes—4 hours) for magnesium citrate and other saline laxatives.

Because of the potential for serious magnesium toxicity in patients with renal impairment, polyethylene glycol (PEG) solution may be a preferred agent over magnesium citrate in these patients prior to GI procedures or surgery (see Polyethylene glycol; Electrolytes monograph).

Magnesium citrate is also used for short-term, acute treatment of constipation, but is not recommended for routine use. The drug is only rarely used for magnesium supplementation, and is not normally recommended for this purpose.

Magnesium citrate oral solutions have been used clinically for decades.

Indications

  • bowel preparation
  • constipation

NOTE: Oral magnesium citrate solution contains 3.85 to 4.71 mEq of magnesium per 5 mL (roughly 250 mEq magnesium per 300 mL bottle).

For use intermittently as a laxative to treat acute constipation

Side Effects

  1. cardiac arrest
  2. confusion
  3. dehydration
  4. diaphoresis
  5. diarrhea
  6. drowsiness
  7. flushing
  8. hypermagnesemia
  9. hyporeflexia
  10. nausea
  11. respiratory arrest
  12. respiratory depression
  13. skin irritation
  14. vomiting
  15. weakness

Monitoring Parameters

  • serum creatinine/BUN
  • serum magnesium

Contraindications

  • abdominal pain
  • appendicitis
  • breast-feeding
  • cardiac disease
  • children
  • colitis
  • colostomy
  • dehydration
  • diabetes mellitus
  • electrolyte imbalance
  • fecal impaction
  • geriatric
  • GI bleeding
  • GI obstruction
  • GI perforation
  • hyperkalemia
  • hypermagnesemia
  • hypocalcemia
  • ileostomy
  • ileus
  • infants
  • metabolic acidosis
  • neonates
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • toxic megacolon
  • vomiting

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Hydrocodone
  • Alendronate
  • Alendronate; Cholecalciferol
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Baloxavir Marboxil
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bumetanide
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Phosphate, Supersaturated
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Choline Salicylate; Magnesium Salicylate
  • Ciprofloxacin
  • Delafloxacin
  • Demeclocycline
  • Dichlorphenamide
  • Digoxin
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Doxycycline
  • Edetate Calcium Disodium, Calcium EDTA
  • Edetate Disodium, Disodium EDTA
  • Ethacrynic Acid
  • Etidronate
  • Furosemide
  • Gemifloxacin
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibandronate
  • Lactulose
  • Levofloxacin
  • Loop diuretics
  • Magnesium
  • Magnesium Hydroxide
  • Magnesium Salicylate
  • Minocycline
  • Moxifloxacin
  • Norfloxacin
  • Ofloxacin
  • Omadacycline
  • Pimozide
  • Potassium-sparing diuretics
  • Risedronate
  • Sarecycline
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Sodium Polystyrene Sulfonate
  • Spironolactone
  • Tetracycline
  • Tetracyclines
  • Tiludronate
  • Torsemide
  • Triamterene
  • Vitamin D
  • Vitamin D analogs
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