Loratadine

Loratadine Brand Names

Alavert | Allergy Relief | Claritin | Claritin Chewable | Claritin Hives Relief | Claritin Liqui-Gel | Claritin RediTab | Claritin-D 24 Hour | Clear-Atadine | Dimetapp Children’s Non-Drowsy Allergy | QlearQuil All Day & All Night Allergy Relief | Tavist ND

What is Loratadine

Loratadine is an oral non-sedating antihistamine (H1-blocker) that is similar in structure to cyproheptadine and azatadine.

Due to poor penetration into the central nervous system (CNS) and a low affinity for CNS histamine H1-receptors, the drug is less likely to cause sedation or other CNS effects compared with traditional, sedating antihistamines.

Unlike astemizole and terfenadine, which are no longer marketed due to arrhythmia risks, loratadine has not been associated with QT prolongation.

Loratadine is used in both adult and pediatric populations for allergic rhinitis and chronic idiopathic urticaria or other allergic symptoms.

Loratadine was first approved by the FDA in April 1993 as a prescription medication.

Loratadine products became approved for non-prescription (OTC) sale in December 2002.

Indications

  1. allergic rhinitis
  2. chronic idiopathic urticaria
  3. exercise-induced bronchospasm prophylaxis
  4. perennial allergies
  5. pruritus
  6. seasonal allergies

For the management of symptoms of seasonal allergies or perennial allergies, including allergic rhinitis

Side Effects

  1. abdominal pain
  2. alopecia
  3. amnesia
  4. anaphylactoid reactions
  5. angioedema
  6. anorexia
  7. anxiety
  8. appetite stimulation
  9. arthralgia
  10. asthenia
  11. blepharospasm
  12. blurred vision
  13. breast enlargement
  14. bronchospasm
  15. chest pain (unspecified)
  16. chills
  17. confusion
  18. conjunctivitis
  19. constipation
  20. cough
  21. depression
  22. diarrhea
  23. dizziness
  24. drowsiness
  25. dysgeusia
  26. dysmenorrhea
  27. dyspepsia
  28. dyspnea
  29. elevated hepatic enzymes
  30. epistaxis
  31. erythema multiforme
  32. fatigue
  33. fever
  34. flatulence
  35. flushing
  36. gastritis
  37. headache
  38. hemoptysis
  39. hepatic necrosis
  40. hepatitis
  41. hiccups
  42. hyperhidrosis
  43. hypertension
  44. hypertonia
  45. hypoesthesia
  46. hypotension
  47. impotence (erectile dysfunction)
  48. infection
  49. insomnia
  50. irritability
  51. jaundice
  52. laryngitis
  53. libido decrease
  54. mastalgia
  55. menorrhagia
  56. migraine
  57. muscle cramps
  58. myalgia
  59. nasal dryness
  60. nausea
  61. ocular pain
  62. otalgia
  63. palpitations
  64. paranoia
  65. paresthesias
  66. peripheral edema
  67. pharyngitis
  68. photosensitivity
  69. polydipsia
  70. pruritus
  71. purpura
  72. rash
  73. seizures
  74. sinus tachycardia
  75. sinusitis
  76. sneezing
  77. stomatitis
  78. supraventricular tachycardia (SVT)
  79. syncope
  80. thrombocytopenia
  81. tinnitus
  82. tremor
  83. urinary incontinence
  84. urinary retention
  85. urine discoloration
  86. urticaria
  87. vaginitis
  88. vertigo
  89. vomiting
  90. weight gain
  91. wheezing
  92. xerosis
  93. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • asthma
  • breast-feeding
  • children
  • driving or operating machinery
  • geriatric
  • hepatic disease
  • infants
  • neonates
  • phenylketonuria
  • pregnancy
  • renal failure
  • renal impairment

Interactions

  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Diphenhydramine
  • Acrivastine; Pseudoephedrine
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlorcyclizine
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Clemastine
  • Cyclizine
  • Cyproheptadine
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • Heparin
  • Hydroxyzine
  • Levocetirizine
  • Meclizine
  • Sedating H1-blockers
  • Sincalide
  • Triprolidine
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