Loratadine Pseudoephedrine

Loratadine Pseudoephedrine Brand Names

Alavert-D | Allergy and Sinus Relief | Allergy Relief & Nasal Decongestant 24 Hour | Claritin-D | Claritin-D 12 Hour | Claritin-D 24 Hour | Clear-Atadine D

What is Loratadine Pseudoephedrine

Loratadine and pseudoephedrine are used in combination for temporary relief of sneezing, rhinorrhea, nasal congestion and itchy, watery eyes and itchy throat throat due to the common cold, hay fever or other upper respiratory allergies.

Loratadine is a non-sedating antihistamine (H1-blocker) that does not readily cross the blood-brain barrier.

Pseudoephedrine is a sympathomimetic amine which is effective in relieving the symptoms of nasal and sinus congestion.

Loratadine pseudoephedrine products were first approved by the FDA in November 1994 and available by prescription; the FDA approved the non-prescription (OTC) use in November 2002.

Indications

  1. allergic rhinitis
  2. common cold
  3. nasal congestion
  4. rhinorrhea
  5. sneezing

For the temporary relief of symptoms due to seasonal allergic rhinitis or the common cold, including sneezing, rhinorrhea, itching of the nose or throat, nasal congestion, and itchy, watery eyes

Side Effects

  1. agitation
  2. anaphylactoid reactions
  3. angina
  4. angioedema
  5. anorexia
  6. anxiety
  7. arrhythmia exacerbation
  8. bronchospasm
  9. chest pain (unspecified)
  10. dizziness
  11. drowsiness
  12. dysuria
  13. erythema multiforme
  14. fatigue
  15. GI obstruction
  16. hallucinations
  17. headache
  18. hypertension
  19. insomnia
  20. myocardial infarction
  21. nausea
  22. ocular hypertension
  23. palpitations
  24. paresthesias
  25. photophobia
  26. premature ventricular contractions (PVCs)
  27. psychosis
  28. restlessness
  29. seizures
  30. sinus tachycardia
  31. stroke
  32. supraventricular tachycardia (SVT)
  33. syncope
  34. tremor
  35. vomiting
  36. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute myocardial infarction
  • angina
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • closed-angle glaucoma
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • dysphagia
  • geriatric
  • GI obstruction
  • heart failure
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • infants
  • MAOI therapy
  • pregnancy
  • prostatic hypertrophy
  • renal disease
  • renal failure
  • renal impairment
  • tachycardia
  • urinary retention

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetazolamide
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alkalinizing Agents
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Ammonium Chloride
  • Amoxapine
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Arformoterol
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azilsartan; Chlorthalidone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Beta-blockers
  • Betaxolol
  • Bethanechol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Bretylium
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide; Formoterol
  • Bumetanide
  • Bupropion
  • Bupropion; Naltrexone
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
  • Carteolol
  • Carvedilol
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorcyclizine
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Clemastine
  • Clevidipine
  • Clonidine
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • Cyclizine
  • Cyproheptadine
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Digitoxin
  • Digoxin
  • Dihydroergotamine
  • Diltiazem
  • Dimenhydrinate
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dopamine
  • Dorzolamide; Timolol
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Droxidopa
  • Dulaglutide
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esmolol
  • Ethacrynic Acid
  • Exenatide
  • Felodipine
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Furosemide
  • Ginger, Zingiber officinale
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guaifenesin; Phenylephrine
  • Guanabenz
  • Halogenated Anesthetics
  • Haloperidol
  • Heparin
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Hydroxyzine
  • Iloprost
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iobenguane I 131
  • Isocarboxazid
  • Isradipine
  • Labetalol
  • Levalbuterol
  • Levobetaxolol
  • Levobunolol
  • Levocetirizine
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lisinopril
  • Lixisenatide
  • Loop diuretics
  • Macitentan
  • Maprotiline
  • Mecamylamine
  • Meclizine
  • Meglitinides
  • Metaproterenol
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methazolamide
  • Methyclothiazide
  • Methyldopa
  • Methylergonovine
  • Methysergide
  • Metolazone
  • Metoprolol
  • Midodrine
  • Miglitol
  • Moexipril
  • Monoamine oxidase inhibitors
  • Nabilone
  • Nadolol
  • Nebivolol
  • Nebivolol; Valsartan
  • Nicardipine
  • Nicotine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrates
  • Norepinephrine
  • Ozanimod
  • Penbutolol
  • Pergolide
  • Perindopril
  • Perindopril; Amlodipine
  • Phenelzine
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Potassium-sparing diuretics
  • Pramlintide
  • Procarbazine
  • Propranolol
  • Quinapril
  • Racepinephrine
  • Ramipril
  • Rasagiline
  • Reserpine
  • Riociguat
  • Rosiglitazone
  • Safinamide
  • Salmeterol
  • Sedating H1-blockers
  • Selegiline
  • Selexipag
  • Semaglutide
  • SGLT2 Inhibitors
  • Sibutramine
  • Sincalide
  • Solriamfetol
  • Sotalol
  • St. John’s Wort, Hypericum perforatum
  • Sulfonylureas
  • Terbutaline
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thyroid hormones
  • Timolol
  • Torsemide
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Treprostinil
  • Tricyclic antidepressants
  • Triprolidine
  • Umeclidinium; Vilanterol
  • Vasodilators
  • Vasopressors
  • Verapamil
  • Yohimbine
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