Lomefloxacin

Lomefloxacin Brand Name– Maxaquin

What is Lomefloxacin

Lomefloxacin is a synthetic, oral broad-spectrum fluoroquinolone antibiotic. Like other fluoroquinolones, lomefloxacin is effective against both gram-positive and gram negative bacteria.

Lomefloxacin has a longer half-life than ciprofloxacin and is administered once daily without regard to meals.

Lomefloxacin is indicated for the treatment of mild to moderate lower respiratory tract and urinary tract infections (UTIs).

Resistance has been exhibited by Streptococcous pneumoniaein vitro and therefore, lomefloxacin should not be used empirically to treat lower respiratory tract infections caused by S. pneumoniae.

Lomefloxacin was approved by the FDA in February 1992.

Indications

  1. Aeromonas hydrophila
  2. bronchitis
  3. Citrobacter diversus
  4. Citrobacter freundii
  5. cystitis
  6. Enterobacter cloacae
  7. Escherichia coli
  8. Haemophilus influenzae (beta-lactamase negative)
  9. Haemophilus influenzae (beta-lactamase positive)
  10. Haemophilus parainfluenzae
  11. Hafnia alvei
  12. Klebsiella aerogenes
  13. Klebsiella oxytoca
  14. Klebsiella ozaenae
  15. Klebsiella pneumoniae
  16. Legionella pneumophila
  17. lower respiratory tract infections
  18. Moraxella catarrhalis
  19. Morganella morganii
  20. Neisseria gonorrhoeae
  21. Pantoea agglomerans
  22. Proteus mirabilis
  23. Proteus vulgaris
  24. Providencia alcalifaciens
  25. Providencia rettgeri
  26. Pseudomonas aeruginosa
  27. Serratia liquefaciens
  28. Serratia marcescens
  29. Staphylococcus aureus (MRSA)
  30. Staphylococcus aureus (MSSA)
  31. Staphylococcus epidermidis
  32. Staphylococcus saprophyticus
  33. surgical infection prophylaxis
  34. urinary tract infection (UTI)

Side Effects

  1. abdominal pain
  2. agitation
  3. anaphylactoid reactions
  4. anemia
  5. angina
  6. angioedema
  7. anorexia
  8. anxiety
  9. appetite stimulation
  10. arthralgia
  11. asthenia
  12. back pain
  13. bradycardia
  14. bronchospasm
  15. bullous rash
  16. candidiasis
  17. cardiomyopathy
  18. chills
  19. coma
  20. confusion
  21. conjunctivitis
  22. constipation
  23. cough
  24. cyanosis
  25. depression
  26. diaphoresis
  27. diarrhea
  28. dizziness
  29. drowsiness
  30. dysgeusia
  31. dyspepsia
  32. dysphagia
  33. dyspnea
  34. eosinophilia
  35. epididymitis
  36. epistaxis
  37. exfoliative dermatitis
  38. fatigue
  39. fever
  40. flatulence
  41. flushing
  42. GI bleeding
  43. gout
  44. hallucinations
  45. headache
  46. heart failure
  47. hepatic necrosis
  48. hot flashes
  49. hyperglycemia
  50. hypertension
  51. hypertonia
  52. hypoglycemia
  53. hypotension
  54. increased intracranial pressure
  55. insomnia
  56. jaundice
  57. lacrimation
  58. leukorrhea
  59. lymphadenopathy
  60. maculopapular rash
  61. malaise
  62. menstrual irregularity
  63. muscle cramps
  64. myalgia
  65. myocardial infarction
  66. nausea
  67. ocular pain
  68. otalgia
  69. paranoia
  70. paresthesias
  71. perineal pain
  72. peripheral neuropathy
  73. pharyngitis
  74. phlebitis
  75. photophobia
  76. photosensitivity
  77. premature ventricular contractions (PVCs)
  78. pruritus
  79. pulmonary embolism
  80. purpura
  81. QT prolongation
  82. rash
  83. respiratory depression
  84. restlessness
  85. rhinitis
  86. seizures
  87. sinus tachycardia
  88. skin discoloration
  89. skin ulcer
  90. stomatitis
  91. syncope
  92. tendon rupture
  93. thrombocytopenia
  94. tinnitus
  95. tongue discoloration
  96. torsade de pointes
  97. tremor
  98. urticaria
  99. vaginitis
  100. vertigo
  101. visual impairment
  102. vomiting
  103. xerostomia

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • alcoholism
  • atrial fibrillation
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cerebrovascular disease
  • children
  • colitis
  • coronary artery disease
  • corticosteroid therapy
  • dehydration
  • diabetes mellitus
  • dialysis
  • diarrhea
  • females
  • geriatric
  • GI disease
  • heart failure
  • hepatic disease
  • hepatitis
  • hepatotoxicity
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • infants
  • inflammatory bowel disease
  • jaundice
  • long QT syndrome
  • malnutrition
  • myasthenia gravis
  • myocardial infarction
  • neonates
  • neurotoxicity
  • organ transplant
  • peripheral neuropathy
  • pregnancy
  • pseudomembranous colitis
  • QT prolongation
  • quinolone hypersensitivity
  • renal failure
  • renal impairment
  • seizure disorder
  • sunlight (UV) exposure
  • tendinitis
  • tendinopathy
  • tendon pain
  • tendon rupture
  • thyroid disease
  • torsade de pointes
  • ulcerative colitis
  • viral infection

Interactions

  • Acetohexamide
  • Aclidinium; Formoterol
  • Albuterol
  • Albuterol; Ipratropium
  • Alfuzosin
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Arformoterol
  • Arsenic Trioxide
  • Bepridil
  • Budesonide; Formoterol
  • Canagliflozin; Metformin
  • Chloroquine
  • Chlorpropamide
  • Cimetidine
  • Cisapride
  • Clarithromycin
  • Class IA Antiarrhythmics
  • Clozapine
  • Colchicine; Probenecid
  • Cyclosporine
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Didanosine, ddI
  • Dolasetron
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enflurane
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Flecainide
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol
  • Formoterol; Mometasone
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycopyrrolate; Formoterol
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hetastarch; Dextrose; Electrolytes
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Insulins
  • Isoflurane
  • Levalbuterol
  • Levomethadyl
  • Linagliptin
  • Linagliptin; Metformin
  • Long-acting beta-agonists
  • Magnesium
  • Magnesium Salts
  • Maprotiline
  • Meglitinides
  • Metaproterenol
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Nateglinide
  • Octreotide
  • Olodaterol
  • Pentamidine
  • Phenothiazines
  • Pimozide
  • Pioglitazone
  • Pirbuterol
  • Pramlintide
  • Probenecid
  • Propafenone
  • Ranitidine
  • Repaglinide
  • Risperidone
  • Rosiglitazone
  • Salmeterol
  • Saxagliptin
  • Sevoflurane
  • SGLT2 Inhibitors
  • Short-acting beta-agonists
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sulfonylureas
  • Tacrolimus
  • Terbutaline
  • Thiazolidinediones
  • Tiotropium; Olodaterol
  • Tolazamide
  • Tolbutamide
  • Tricyclic antidepressants
  • Umeclidinium; Vilanterol
  • Vardenafil
  • Warfarin
  • Ziprasidone