Lidocaine Prilocaine Brand Names
ANODYNE LPT | Aprizio Pak II | Dolotranz | EMLA | Empricaine-II | Lido-Prilo Caine | LiProZonePak | LIVIXIL Pak | LP Lite Pak | Medolor Pak with Tegaderm Dressing | Microvix LP | Nuvakaan-II | Oraqix | Prilovix | Prilovix Lite | Prilovix Lite Plus | Prilovix Plus | Prilovix Ultralite | Prilovix Ultralite Plus | Prilovixil | Relador
What is Lidocaine Prilocaine
The combination of lidocaine 2.5% and prilocaine 2.5% provides two amide local anesthetics for topical administration.
EMLA®, an acronym for Eutectic Mixture of Local Anesthetics, is an emulsion and is available as a cream. The cream must be covered by an occlusive dressing (e.g., Saran Wrap®, Band-Aid®, Tegaderm®, or DuoDerm®).
The lidocaine; prilocaine combination is also available as a microemulsion for dental use.
The microemulsion contains poloxamer excipients and is a fluid at room temperature and an elastic gel when applied to the periodontal pocket. The FDA approved the EMLA® cream in December 1992 and the Oraqix® periodontal gel in December 2003.
The EMLA® anesthetic disc was approved in February 1998 but was removed from the U.S. market in February 2005.
Indications
- local anesthesia
- premature ejaculation
- topical anesthesia
For use as local anesthesia to provide topical anesthesia
application to intact skin prior to minor dermal procedures (e.g., intravenous cannulation and venipuncture)
Side Effects
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- arrhythmia exacerbation
- arthralgia
- arthropathy
- blurred vision
- bradycardia
- bronchospasm
- cardiac arrest
- contact dermatitis
- dizziness
- drowsiness
- dysesthesia
- dysgeusia
- edema
- erythema
- fatigue
- headache
- hyperacusis
- hypotension
- infection
- methemoglobinemia
- myalgia
- nausea
- oral ulceration
- pallor
- pruritus
- purpura
- rash
- seizures
- skin hyperpigmentation
- tremor
- urticaria
- vesicular rash
- visual impairment
Monitoring Parameters
- methemoglobin
Contraindications
- amide local anesthetic hypersensitivity
- breast-feeding
- burns
- cardiac disease
- eczema
- G6PD deficiency
- geriatric
- hepatic disease
- hepatic encephalopathy
- hepatitis
- infants
- intravenous administration
- labor
- methemoglobinemia
- neonates
- obstetric delivery
- occlusive dressing
- ocular exposure
- pregnancy
- premature neonates
- pulmonary disease
- skin abrasion
- tympanic membrane perforation
Lidocaine; prilocaine is contraindicated in patients with amide local anesthetic hypersensitivity or hypersensitivity to any component of the product.
Interactions
- Acebutolol
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Adapalene; Benzoyl Peroxide
- Aldesleukin, IL-2
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Ambenonium Chloride
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Amyl Nitrite
- Anagrelide
- Apalutamide
- Aprepitant, Fosaprepitant
- Articaine; Epinephrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atracurium
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzocaine
- Benzocaine; Butamben; Tetracaine
- Benzonatate
- Benzoyl Peroxide
- Benzoyl Peroxide; Clindamycin
- Benzoyl Peroxide; Erythromycin
- Benzoyl Peroxide; Sulfur
- Beta-adrenergic blockers
- Betaxolol
- Bexarotene
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bosentan
- Brimonidine; Timolol
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Caffeine; Ergotamine
- Capmatinib
- Capreomycin
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carteolol
- Carvedilol
- Ceritinib
- Chloramphenicol
- Chloroprocaine
- Chloroquine
- Chloroxylenol; Hydrocortisone; Pramoxine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cholinesterase inhibitors
- Cimetidine
- Ciprofloxacin
- Cisatracurium
- Citalopram
- Clarithromycin
- Clomipramine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colesevelam
- Conivaptan
- Crizotinib
- Cyclophosphamide
- Cyclosporine
- Dabrafenib
- Dalfopristin; Quinupristin
- Danazol
- Dapsone
- Daratumumab; Hyaluronidase
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Delavirdine
- Desipramine
- Dexamethasone
- Dextromethorphan; Quinidine
- Dibucaine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Disulfiram
- Dofetilide
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxacurium
- Doxepin
- Dronedarone
- Edrophonium
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enflurane
- Enzalutamide
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Esmolol
- Ethotoin
- Ethyl Chloride
- Etomidate
- Etravirine
- Famotidine
- Famotidine; Ibuprofen
- Felbamate
- Fentanyl
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flutamide
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Fospropofol
- Furazolidone
- Galantamine
- General anesthetics
- Ginger, Zingiber officinale
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halothane
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone; Pramoxine
- Hydromorphone
- Hydroxyurea
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Imatinib
- Imipramine
- Indinavir
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Itraconazole
- Ketamine
- Ketoconazole
- Labetalol
- Lacosamide
- Lapatinib
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levobetaxolol
- Levobunolol
- Levomethadyl
- Levorphanol
- Lopinavir; Ritonavir
- Lorlatinib
- Magnesium Salts
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Methadone
- Methohexital
- Methylergonovine
- Methysergide
- Metoclopramide
- Metoprolol
- Mexiletine
- Minocycline
- Mitotane
- Mivacurium
- Modafinil
- Monoamine oxidase inhibitors
- Moricizine
- Morphine
- Morphine; Naltrexone
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Neostigmine
- Netupitant, Fosnetupitant; Palonosetron
- Neuromuscular blockers
- Nevirapine
- Nilotinib
- Nitrates
- Nitrofurantoin
- Nitroglycerin
- Nortriptyline
- Obeticholic Acid
- Octreotide
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Osilodrostat
- Oxycodone
- Oxymorphone
- Palbociclib
- Pancuronium
- Pazopanib
- Peginterferon Alfa-2b
- Penbutolol
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pergolide
- Perindopril; Amlodipine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phentermine; Topiramate
- Phenytoin
- Physostigmine
- Pindolol
- Polymyxins
- Posaconazole
- Pramoxine
- Prilocaine
- Prilocaine; Epinephrine
- Primaquine
- Primidone
- Procainamide
- Procarbazine
- Propafenone
- Propofol
- Propoxyphene
- Propranolol
- Protriptyline
- Pyridostigmine
- Pyrimethamine; Sulfadoxine
- Quinidine
- Quinine
- Ranolazine
- Rapacuronium
- Rasburicase
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Rituximab; Hyaluronidase
- Rivastigmine
- Rocuronium
- Ropivacaine
- Rucaparib
- Saquinavir
- Selpercatinib
- Sevoflurane
- Simeprevir
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Succinylcholine
- Sufentanil
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Tacrine
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Teriflunomide
- Tetracaine
- Thiabendazole
- Thiopental
- Ticagrelor
- Ticlopidine
- Timolol
- Tipranavir
- Tocainide
- Topiramate
- Trandolapril; Verapamil
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Tricyclic antidepressants
- Trimipramine
- Tubocurarine
- Tucatinib
- Valproic Acid, Divalproex Sodium
- Vecuronium
- Verapamil
- Voriconazole
- Zafirlukast
