Lidocaine Prilocaine

Lidocaine Prilocaine Brand Names

What is Lidocaine Prilocaine

The combination of lidocaine 2.5% and prilocaine 2.5% provides two amide local anesthetics for topical administration.

EMLA®, an acronym for Eutectic Mixture of Local Anesthetics, is an emulsion and is available as a cream. The cream must be covered by an occlusive dressing (e.g., Saran Wrap®, Band-Aid®, Tegaderm®, or DuoDerm®).

The lidocaine; prilocaine combination is also available as a microemulsion for dental use.

The microemulsion contains poloxamer excipients and is a fluid at room temperature and an elastic gel when applied to the periodontal pocket. The FDA approved the EMLA® cream in December 1992 and the Oraqix® periodontal gel in December 2003.

The EMLA® anesthetic disc was approved in February 1998 but was removed from the U.S. market in February 2005.

Indications

local anesthesia
premature ejaculation
topical anesthesia

For use as local anesthesia to provide topical anesthesia

application to intact skin prior to minor dermal procedures (e.g., intravenous cannulation and venipuncture)

Side Effects

anaphylactic shock
anaphylactoid reactions
angioedema
arrhythmia exacerbation
arthralgia
arthropathy
blurred vision
bradycardia
bronchospasm
cardiac arrest
contact dermatitis
dizziness
drowsiness
dysesthesia
dysgeusia
edema
erythema
fatigue
headache
hyperacusis
hypotension
infection
methemoglobinemia
myalgia
nausea
oral ulceration
pallor
pruritus
purpura
rash
seizures
skin hyperpigmentation
tremor
urticaria
vesicular rash
visual impairment

Monitoring Parameters

methemoglobin

Contraindications

amide local anesthetic hypersensitivity
breast-feeding
burns
cardiac disease
eczema
G6PD deficiency
geriatric
hepatic disease
hepatic encephalopathy
hepatitis
infants
intravenous administration
labor
methemoglobinemia
neonates
obstetric delivery
occlusive dressing
ocular exposure
pregnancy
premature neonates
pulmonary disease
skin abrasion
tympanic membrane perforation

Lidocaine; prilocaine is contraindicated in patients with amide local anesthetic hypersensitivity or hypersensitivity to any component of the product.

Interactions

Acebutolol
Acetaminophen
Acetaminophen; Aspirin, ASA; Caffeine
Acetaminophen; Butalbital
Acetaminophen; Butalbital; Caffeine
Acetaminophen; Butalbital; Caffeine; Codeine
Acetaminophen; Caffeine
Acetaminophen; Caffeine; Dihydrocodeine
Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
Acetaminophen; Codeine
Acetaminophen; Dextromethorphan
Acetaminophen; Dextromethorphan; Doxylamine
Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
Acetaminophen; Dextromethorphan; Phenylephrine
Acetaminophen; Dextromethorphan; Pseudoephedrine
Acetaminophen; Dichloralphenazone; Isometheptene
Acetaminophen; Diphenhydramine
Acetaminophen; Guaifenesin; Phenylephrine
Acetaminophen; Hydrocodone
Acetaminophen; Oxycodone
Acetaminophen; Pentazocine
Acetaminophen; Propoxyphene
Acetaminophen; Pseudoephedrine
Acetaminophen; Tramadol
Adapalene; Benzoyl Peroxide
Aldesleukin, IL-2
Alfentanil
Aliskiren; Amlodipine
Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
Ambenonium Chloride
Aminosalicylate sodium, Aminosalicylic acid
Amiodarone
Amitriptyline
Amitriptyline; Chlordiazepoxide
Amlodipine
Amlodipine; Atorvastatin
Amlodipine; Benazepril
Amlodipine; Celecoxib
Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
Amlodipine; Olmesartan
Amlodipine; Telmisartan
Amlodipine; Valsartan
Amoxicillin; Clarithromycin; Lansoprazole
Amoxicillin; Clarithromycin; Omeprazole
Amprenavir
Amyl Nitrite
Anagrelide
Apalutamide
Aprepitant, Fosaprepitant
Articaine; Epinephrine
Aspirin, ASA; Butalbital; Caffeine; Codeine
Aspirin, ASA; Caffeine; Dihydrocodeine
Aspirin, ASA; Carisoprodol; Codeine
Aspirin, ASA; Oxycodone
Atazanavir
Atazanavir; Cobicistat
Atenolol
Atenolol; Chlorthalidone
Atracurium
Atropine; Edrophonium
Atropine; Hyoscyamine; Phenobarbital; Scopolamine
Belladonna Alkaloids; Ergotamine; Phenobarbital
Belladonna; Opium
Bendroflumethiazide; Nadolol
Benzhydrocodone; Acetaminophen
Benzocaine
Benzocaine; Butamben; Tetracaine
Benzonatate
Benzoyl Peroxide
Benzoyl Peroxide; Clindamycin
Benzoyl Peroxide; Erythromycin
Benzoyl Peroxide; Sulfur
Beta-adrenergic blockers
Betaxolol
Bexarotene
Bisoprolol
Bisoprolol; Hydrochlorothiazide, HCTZ
Boceprevir
Bosentan
Brimonidine; Timolol
Brompheniramine; Guaifenesin; Hydrocodone
Brompheniramine; Hydrocodone; Pseudoephedrine
Bupivacaine
Bupivacaine Liposomal
Bupivacaine; Lidocaine
Caffeine; Ergotamine
Capmatinib
Capreomycin
Carbamazepine
Carbinoxamine; Hydrocodone; Phenylephrine
Carbinoxamine; Hydrocodone; Pseudoephedrine
Carteolol
Carvedilol
Ceritinib
Chloramphenicol
Chloroprocaine
Chloroquine
Chloroxylenol; Hydrocortisone; Pramoxine
Chlorpheniramine; Codeine
Chlorpheniramine; Dihydrocodeine; Phenylephrine
Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
Chlorpheniramine; Hydrocodone
Chlorpheniramine; Hydrocodone; Phenylephrine
Chlorpheniramine; Hydrocodone; Pseudoephedrine
Cholinesterase inhibitors
Cimetidine
Ciprofloxacin
Cisatracurium
Citalopram
Clarithromycin
Clomipramine
Cobicistat
Codeine
Codeine; Guaifenesin
Codeine; Phenylephrine; Promethazine
Codeine; Promethazine
Colesevelam
Conivaptan
Crizotinib
Cyclophosphamide
Cyclosporine
Dabrafenib
Dalfopristin; Quinupristin
Danazol
Dapsone
Daratumumab; Hyaluronidase
Darunavir
Darunavir; Cobicistat
Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
Deferasirox
Delavirdine
Desipramine
Dexamethasone
Dextromethorphan; Quinidine
Dibucaine
Dihydrocodeine; Guaifenesin; Pseudoephedrine
Dihydroergotamine
Diltiazem
Diphenhydramine; Hydrocodone; Phenylephrine
Disopyramide
Disulfiram
Dofetilide
Donepezil
Donepezil; Memantine
Dorzolamide; Timolol
Doxacurium
Doxepin
Dronedarone
Edrophonium
Efavirenz
Efavirenz; Emtricitabine; Tenofovir
Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
Elagolix
Elagolix; Estradiol; Norethindrone acetate
Elbasvir; Grazoprevir
Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
Enflurane
Enzalutamide
Ergoloid Mesylates
Ergonovine
Ergot alkaloids
Ergotamine
Erythromycin; Sulfisoxazole
Eslicarbazepine
Esmolol
Ethotoin
Ethyl Chloride
Etomidate
Etravirine
Famotidine
Famotidine; Ibuprofen
Felbamate
Fentanyl
Flecainide
Fluconazole
Fluoxetine
Fluoxetine; Olanzapine
Flutamide
Fluvoxamine
Fosamprenavir
Fosphenytoin
Fospropofol
Furazolidone
Galantamine
General anesthetics
Ginger, Zingiber officinale
Guaifenesin; Hydrocodone
Guaifenesin; Hydrocodone; Pseudoephedrine
Halothane
Homatropine; Hydrocodone
Hyaluronidase
Hyaluronidase, Recombinant; Immune Globulin
Hydralazine; Isosorbide Dinitrate, ISDN
Hydrochlorothiazide, HCTZ; Metoprolol
Hydrochlorothiazide, HCTZ; Propranolol
Hydrocodone
Hydrocodone; Ibuprofen
Hydrocodone; Phenylephrine
Hydrocodone; Potassium Guaiacolsulfonate
Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
Hydrocodone; Pseudoephedrine
Hydrocortisone; Pramoxine
Hydromorphone
Hydroxyurea
Ibuprofen; Oxycodone
Idelalisib
Ifosfamide
Imatinib
Imipramine
Indinavir
Isavuconazonium
Isocarboxazid
Isoflurane
Isoniazid, INH
Isoniazid, INH; Pyrazinamide, PZA; Rifampin
Isoniazid, INH; Rifampin
Isosorbide Dinitrate, ISDN
Isosorbide Mononitrate
Itraconazole
Ketamine
Ketoconazole
Labetalol
Lacosamide
Lapatinib
Lesinurad
Lesinurad; Allopurinol
Letermovir
Levobetaxolol
Levobunolol
Levomethadyl
Levorphanol
Lopinavir; Ritonavir
Lorlatinib
Magnesium Salts
Meperidine
Meperidine; Promethazine
Mephobarbital
Mepivacaine
Mepivacaine; Levonordefrin
Methadone
Methohexital
Methylergonovine
Methysergide
Metoclopramide
Metoprolol
Mexiletine
Minocycline
Mitotane
Mivacurium
Modafinil
Monoamine oxidase inhibitors
Moricizine
Morphine
Morphine; Naltrexone
Nadolol
Nebivolol
Nebivolol; Valsartan
Nefazodone
Nelfinavir
Neostigmine
Netupitant, Fosnetupitant; Palonosetron
Neuromuscular blockers
Nevirapine
Nilotinib
Nitrates
Nitrofurantoin
Nitroglycerin
Nortriptyline
Obeticholic Acid
Octreotide
Ombitasvir; Paritaprevir; Ritonavir
Omeprazole; Amoxicillin; Rifabutin
Oritavancin
Osilodrostat
Oxycodone
Oxymorphone
Palbociclib
Pancuronium
Pazopanib
Peginterferon Alfa-2b
Penbutolol
Penicillin G Benzathine; Penicillin G Procaine
Penicillin G Procaine
Pergolide
Perindopril; Amlodipine
Perphenazine; Amitriptyline
Phenelzine
Phenobarbital
Phentermine; Topiramate
Phenytoin
Physostigmine
Pindolol
Polymyxins
Posaconazole
Pramoxine
Prilocaine
Prilocaine; Epinephrine
Primaquine
Primidone
Procainamide
Procarbazine
Propafenone
Propofol
Propoxyphene
Propranolol
Protriptyline
Pyridostigmine
Pyrimethamine; Sulfadoxine
Quinidine
Quinine
Ranolazine
Rapacuronium
Rasburicase
Remifentanil
Ribociclib
Ribociclib; Letrozole
Rifabutin
Rifampin
Rifapentine
Ritonavir
Rituximab; Hyaluronidase
Rivastigmine
Rocuronium
Ropivacaine
Rucaparib
Saquinavir
Selpercatinib
Sevoflurane
Simeprevir
St. John’s Wort, Hypericum perforatum
Streptogramins
Succinylcholine
Sufentanil
Sulfadiazine
Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
Sulfasalazine
Sulfisoxazole
Sulfonamides
Tacrine
Telaprevir
Telithromycin
Telotristat Ethyl
Teriflunomide
Tetracaine
Thiabendazole
Thiopental
Ticagrelor
Ticlopidine
Timolol
Tipranavir
Tocainide
Topiramate
Trandolapril; Verapamil
Tranylcypromine
Trastuzumab; Hyaluronidase
Tricyclic antidepressants
Trimipramine
Tubocurarine
Tucatinib
Valproic Acid, Divalproex Sodium
Vecuronium
Verapamil
Voriconazole
Zafirlukast

Porfimer

Clinical course of Membranous Nephropathy

Serologic diagnosis of parvo B19 infection

Head Lice