Bupivacaine Lidocaine

Bupivacaine Lidocaine Brand Names

BL Kit | Duocaine | Marlido | Marlido-25

What is Bupivacaine Lidocaine

Bupivacaine lidocaine (Duocaine™) is a long-acting local anesthetic combination developed to provide local or regional anesthesia for ophthalmic surgery.

Both bupivacaine and lidocaine are both amide-type local anesthetics and therefore share chemical and pharmacologic properties, although bupivacaine has a higher degree of lipid solubility and is protein bound to a greater extent than lidocaine.

The Duocaine™ brand of bupivacaine lidocaine was approved by the FDA in May 2003.

Indications

• ophthalmic anesthesia

For local or regional anesthesia, specifically, ophthalmic anesthesia for ophthalmologic surgery (i.e., peribulbar, retrobulbar, or facial nerve block)

Side Effects

1. anaphylactic shock
2. anaphylactoid reactions
3. angina
4. angioedema
5. anxiety
6. AV block
7. back pain
8. blurred vision
9. bradycardia
10. bronchospasm
11. cardiac arrest
12. chondrolysis
13. coma
14. confusion
15. cranial nerve palsies
16. dizziness
17. drowsiness
18. fecal incontinence
19. headache
20. hypotension
21. injection site reaction
22. meningitis
23. methemoglobinemia
24. muscle paralysis
25. nausea
26. palpitations
27. paresthesias
28. PR prolongation
29. pruritus
30. QT prolongation
31. rash
32. respiratory arrest
33. respiratory depression
34. restlessness
35. seizures
36. tremor
37. urinary incontinence
38. urinary retention
39. urticaria
40. ventricular fibrillation
41. ventricular tachycardia
42. vomiting
43. weakness

Monitoring Parameters

• laboratory monitoring not necessary
• ophthalmologic exam

Contraindications

• Adams-Stokes syndrome
• amide local anesthetic hypersensitivity
• AV block
• bradycardia
• breast-feeding
• cardiac disease
• cardiogenic shock
• children
• continuous intraarticular infusion administration
• dehydration
• G6PD deficiency
• geriatric
• head and neck anesthesia
• hemorrhagic shock
• hepatic disease
• hypotension
• hypovolemia
• infants
• intraarterial administration
• intrathecal administration
• intravenous administration
• labor
• methemoglobinemia
• myasthenia gravis
• neonates
• obstetric delivery
• ocular surgery
• pregnancy
• pulmonary disease
• QT prolongation
• renal failure
• renal impairment
• shock
• spinal anesthesia
• Wolff-Parkinson-White syndrome

Interactions

• Acebutolol
• Acetaminophen
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Aldesleukin, IL-2
• Alfentanil
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• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amprenavir
• Amyl Nitrite
• Anagrelide
• Apalutamide
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• Articaine; Epinephrine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
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• Benzocaine
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