Hydrochlorothiazide Metoprolol

Hydrochlorothiazide Metoprolol Brand Names- DUTOPROL | Lopressor HCT

What is Hydrochlorothiazide Metoprolol

Hydrochlorothiazide Metoprolol are used together in an oral preparation to treat hypertension.

Hydrochlorothiazide is a thiazide diuretic. Metoprolol is a competitive, beta₁-selective (cardioselective) adrenergic antagonist, which is most similar to atenolol.

Metoprolol has moderate lipid solubility, lacks intrinsic sympathomimetic activity (ISA), and has weak membrane stabilizing activity (MSA). Metoprolol is more lipid-soluble than atenolol, but less lipid-soluble than propranolol or betaxolol.

The degree of lipid solubility affects the route of elimination of metoprolol (extensively metabolized) and, theoretically, its potential for CNS side effects. Metoprolol has a relatively short elimination half-life compared to other cardioselective beta-blockers.

Lopressor HCT was approved by the FDA in December 1984.

Dutoprol tablets (extended-release metoprolol succinate and immediate-release hydrochlorothiazide) were approved by the FDA in August 2006 but did not become commercially available in the United States until 2012.

Indications

• hypertension

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. amnesia
5. anorexia
6. aplastic anemia
7. AV block
8. azotemia
9. blurred vision
10. bradycardia
11. bronchospasm
12. confusion
13. depression
14. diabetes mellitus
15. diaphoresis
16. diarrhea
17. dizziness
18. drowsiness
19. dyspnea
20. edema
21. elevated hepatic enzymes
22. erythema
23. exfoliative dermatitis
24. fatigue
25. fever
26. flatulence
27. glycosuria
28. gout
29. hallucinations
30. headache
31. heart failure
32. hemolytic anemia
33. hepatitis
34. hyperbilirubinemia
35. hypercalcemia
36. hypercholesterolemia
37. hyperglycemia
38. hypertension
39. hypertriglyceridemia
40. hyperuricemia
41. hypochloremia
42. hypoglycemia
43. hypokalemia
44. hypomagnesemia
45. hyponatremia
46. hypophosphatemia
47. hypovolemia
48. impotence (erectile dysfunction)
49. influenza
50. insomnia
51. interstitial nephritis
52. jaundice
53. laryngospasm
54. leukopenia
55. lupus-like symptoms
56. metabolic alkalosis
57. muscle cramps
58. musculoskeletal pain
59. myopia
60. nausea
61. nephrolithiasis
62. nightmares
63. ocular hypertension
64. orthostatic hypotension
65. otalgia
66. palpitations
67. pancreatitis
68. pancytopenia
69. periarteritis
70. peripheral vasoconstriction
71. photosensitivity
72. pneumonitis
73. pruritus
74. psoriaform rash
75. psoriasis
76. psychosis
77. pulmonary edema
78. purpura
79. pyrosis (heartburn)
80. rash
81. renal failure (unspecified)
82. rhinitis
83. sialadenitis
84. sinus tachycardia
85. Stevens-Johnson syndrome
86. syncope
87. thrombocytopenia
88. tinnitus
89. toxic epidermal necrolysis
90. tremor
91. urticaria
92. vertigo
93. visual impairment
94. vomiting
95. wheezing
96. withdrawal
97. xanthopsia
98. xerophthalmia
99. xerostomia

Monitoring Parameters

• blood glucose
• blood pressure
• heart rate
• serum creatinine/BUN
• serum electrolytes
• serum uric acid

Contraindications

• abrupt discontinuation
• acute bronchospasm
• anuria
• asthma
• AV block
• beta-blocker hypersensitivity
• bradycardia
• breast-feeding
• bronchitis
• cardiogenic shock
• cerebrovascular disease
• chronic obstructive pulmonary disease (COPD)
• depression
• diabetes mellitus
• driving or operating machinery
• electrolyte imbalance
• emphysema
• geriatric
• gout
• heart failure
• hepatic disease
• hypercalcemia
• hypercholesterolemia
• hyperglycemia
• hyperthyroidism
• hypertriglyceridemia
• hyperuricemia
• hypochloremia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypotension
• hypovolemia
• metabolic alkalosis
• myasthenia gravis
• orthostatic hypotension
• pancreatitis
• penicillin hypersensitivity
• peripheral vascular disease
• pheochromocytoma
• preeclampsia
• pregnancy
• psoriasis
• pulmonary disease
• pulmonary edema
• Raynaud’s phenomenon
• renal disease
• renal failure
• renal impairment
• sick sinus syndrome
• sulfonamide hypersensitivity
• sunlight (UV) exposure
• surgery
• sympathectomy
• syncope
• systemic lupus erythematosus (SLE)
• thiazide diuretic hypersensitivity
• thyroid disease
• thyrotoxicosis
• vasospastic angina
• ventricular dysfunction
• Wolff-Parkinson-White syndrome

Interactions

• Abiraterone
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