Hydrochlorothiazide Moexipril

Hydrochlorothiazide Moexipril Brand Name– Uniretic

What is Hydrochlorothiazide Moexipril

Hydrochlorothiazide Moexipril are used together in an oral preparation to treat hypertension.

These ingredients have additive hypotensive activity. Hydrochlorothiazide is a thiazide diuretic.

Moexipril is an angiotensin-converting enzyme (ACE) inhibitor. Moexipril can counteract the hypokalemia caused by hydrochlorothiazide. Like quinapril and ramipril, the active moiety of moexipril is produced by de-esterification from the prodrug.

Moexiprilat, is about 1000 times more potent than its prodrug moexipril. Prolonged antihypertensive effects allow for once daily dosing. Unlike captopril, moexipril does not contain a sulfhydryl group, which has implications regarding the drug’s adverse reaction profile.

Like other ACE inhibitors, moexipril monotherapy is less effective in black hypertensive patients (a low-renin hypertensive population); however, efficacy when combined with hydrochlorothiazide appears to be independent of race.

Uniretic was granted FDA approval for the treatment of hypertension on June 27, 1997.

Indications

• hypertension

Side Effects

1. abdominal pain
2. acne vulgaris
3. agranulocytosis
4. alopecia
5. amnesia
6. anaphylactoid reactions
7. anemia
8. angioedema
9. anorexia
10. anuria
11. anxiety
12. aplastic anemia
13. appetite stimulation
14. arrhythmia exacerbation
15. arthralgia
16. asthenia
17. ataxia
18. atrial fibrillation
19. AV block
20. azotemia
21. back pain
22. blurred vision
23. bradycardia
24. breast enlargement
25. bundle-branch block
26. candidiasis
27. cardiac arrest
28. cataracts
29. cheilitis
30. chest pain (unspecified)
31. chills
32. cholelithiasis
33. cholestasis
34. colitis
35. conjunctivitis
36. constipation
37. contact dermatitis
38. cough
39. crystalluria
40. cystitis
41. dehydration
42. dental caries
43. depression
44. diaphoresis
45. diarrhea
46. dizziness
47. drowsiness
48. dysmenorrhea
49. dyspepsia
50. dysphagia
51. dyspnea
52. dysuria
53. ecchymosis
54. elevated hepatic enzymes
55. emotional lability
56. eosinophilia
57. epistaxis
58. eructation
59. erythema nodosum
60. esophagitis
61. exfoliative dermatitis
62. fatigue
63. fever
64. flatulence
65. flushing
66. furunculosis
67. gastritis
68. GI bleeding
69. gingivitis
70. glossitis
71. glycosuria
72. goiter
73. gout
74. headache
75. hematuria
76. hemolysis
77. hemolytic anemia
78. hemoptysis
79. hepatic failure
80. hepatic necrosis
81. hepatitis
82. hyperamylasemia
83. hyperbilirubinemia
84. hypercalcemia
85. hypercholesterolemia
86. hyperglycemia
87. hyperkalemia
88. hypertonia
89. hypertriglyceridemia
90. hyperuricemia
91. hypocalcemia
92. hypochloremia
93. hypoesthesia
94. hypokalemia
95. hypomagnesemia
96. hyponatremia
97. hypophosphatemia
98. hypotension
99. hypovolemia
100. impotence (erectile dysfunction)
101. increased urinary frequency
102. infection
103. influenza
104. insomnia
105. iritis
106. jaundice
107. laryngeal edema
108. laryngitis
109. leukopenia
110. leukorrhea
111. libido decrease
112. lymphadenopathy
113. lymphocytosis
114. maculopapular rash
115. melena
116. migraine
117. myalgia
118. myopia
119. nausea
120. nephrolithiasis
121. neuritis
122. nocturia
123. ocular hemorrhage
124. ocular hypertension
125. oliguria
126. orthostatic hypotension
127. otalgia
128. palpitations
129. pancreatitis
130. pancytopenia
131. paresthesias
132. pemphigus
133. peripheral edema
134. petechiae
135. pharyngitis
136. photosensitivity
137. pneumonitis
138. polyuria
139. pruritus
140. psoriasis
141. purpura
142. pyuria
143. rash
144. renal failure (unspecified)
145. rhinitis
146. sinus tachycardia
147. sinusitis
148. Stevens-Johnson syndrome
149. stomatitis
150. syncope
151. teratogenesis
152. tinnitus
153. tongue discoloration
154. toxic epidermal necrolysis
155. urinary retention
156. urticaria
157. vaginal bleeding
158. vaginitis
159. ventricular fibrillation
160. vertigo
161. vomiting
162. weight gain
163. xanthopsia
164. xerosis
165. xerostomia

Monitoring Parameters

• blood glucose
• blood pressure
• serum creatinine/BUN
• serum electrolytes
• serum uric acid

Contraindications

• ACE-inhibitor induced angioedema
• angioedema
• Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
• anuria
• aortic stenosis
• asthma
• atopy
• autoimmune disease
• Black patients
• bone marrow suppression
• breast-feeding
• cardiomyopathy
• cerebrovascular disease
• children
• collagen-vascular disease
• coronary artery disease
• diabetes mellitus
• dialysis
• electrolyte imbalance
• geriatric
• gout
• heart failure
• hepatic disease
• hereditary angioedema
• history of angioedema
• hymenoptera venom (insect sting) allergy desensitization
• hyperglycemia
• hyperkalemia
• hyperuricemia
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypotension
• hypovolemia
• immunosuppression
• low-density lipoprotein apheresis
• orthostatic hypotension
• pancreatitis
• penicillin hypersensitivity
• pregnancy
• renal artery stenosis
• renal disease
• renal failure
• renal impairment
• scleroderma
• sulfonamide hypersensitivity
• sunlight (UV) exposure
• surgery
• sympathectomy
• syncope
• systemic lupus erythematosus (SLE)
• thiazide diuretic hypersensitivity

Interactions

• Acarbose
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Acetazolamide
• Acetohexamide
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alemtuzumab
• Alendronate; Cholecalciferol
• Alfentanil
• Aliskiren
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Allopurinol
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Alprostadil
• Amifostine
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminolevulinic Acid
• Amiodarone
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamine; Dextroamphetamine Salts
• Amphotericin B
• Amphotericin B cholesteryl sulfate complex (ABCD)
• Amphotericin B lipid complex (ABLC)
• Amphotericin B liposomal (LAmB)
• Amyl Nitrite
• Angiotensin II
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anticholinergics
• Apomorphine
• Apraclonidine
• Aprotinin
• Arformoterol
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• Arsenic Trioxide
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Atracurium
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azathioprine
• Azilsartan
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Benzhydrocodone; Acetaminophen
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Benztropine
• Beta-agonists
• Bortezomib
• Bosentan
• Brexpiprazole
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Budesonide; Formoterol
• Buprenorphine
• Buprenorphine; Naloxone
• Cabergoline
• Calcium
• Calcium Phosphate, Supersaturated
• Calcium; Vitamin D
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cardiac glycosides
• Cariprazine
• Carvedilol
• Celecoxib
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chlordiazepoxide; Clidinium
• Chloroprocaine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpropamide
• Cholestyramine
• Cidofovir
• Cisapride
• Cisatracurium
• Citalopram
• Clindamycin; Tretinoin
• Clozapine
• Co-Enzyme Q10, Ubiquinone
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Colchicine; Probenecid
• Colestipol
• Conivaptan
• Corticosteroids
• Cosyntropin
• Cyclophosphamide
• Cyclosporine
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Desloratadine; Pseudoephedrine
• Desvenlafaxine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexlansoprazole
• Dexmethylphenidate
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Quinidine
• Diazoxide
• Dichlorphenamide
• Diclofenac
• Diclofenac; Misoprostol
• Dicyclomine
• Diethylpropion
• Diflunisal
• Digitoxin
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Dobutamine
• Dofetilide
• Dolasetron
• Donepezil; Memantine
• Dopamine
• Doxacurium
• Droperidol
• Drospirenone
• Drospirenone; Estradiol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Dulaglutide
• Duloxetine
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Entecavir
• Ephedrine
• Epinephrine
• Eplerenone
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergocalciferol, Vitamin D2
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Escitalopram
• Esomeprazole
• Esomeprazole; Naproxen
• Estradiol
• Estradiol Cypionate; Medroxyprogesterone
• Ethanol
• Etodolac
• Etomidate
• Everolimus
• Exenatide
• Famotidine; Ibuprofen
• Fenoprofen
• Fentanyl
• Fexofenadine; Pseudoephedrine
• Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
• Flavoxate
• Fluconazole
• Fluocinolone; Hydroquinone; Tretinoin
• Fluorescein
• Fluoxetine
• Fluoxetine; Olanzapine
• Flurbiprofen
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Gallium Ga 68 Dotatate
• General anesthetics
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Gold
• Granisetron
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guaifenesin; Pseudoephedrine
• Halobetasol; Tazarotene
• Halofantrine
• Haloperidol
• Halothane
• Heparin
• Homatropine; Hydrocodone
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibritumomab Tiuxetan
• Ibuprofen
• Ibuprofen lysine
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Icatibant
• Icosapent ethyl
• Iloperidone
• Iloprost
• Inamrinone
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Indomethacin
• Inotersen
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Intravenous Lipid Emulsions
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Irbesartan
• Iron Dextran
• Isocarboxazid
• Isoflurane
• Isoproterenol
• Isosorbide Dinitrate, ISDN
• Isosorbide Mononitrate
• Isosulfan Blue
• Kanamycin
• Ketamine
• Ketoprofen
• Ketorolac
• Lansoprazole
• Lansoprazole; Naproxen
• Lanthanum Carbonate
• Lesinurad; Allopurinol
• Levalbuterol
• Levodopa
• Levomethadyl
• Levomilnacipran
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Liraglutide
• Lisdexamfetamine
• Lisinopril
• Lithium
• Lixisenatide
• Loop diuretics
• Loratadine; Pseudoephedrine
• Losartan
• Lovastatin; Niacin
• Lurasidone
• Magnesium Salts
• Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
• Mannitol
• Meclofenamate Sodium
• Mefenamic Acid
• Meglitinides
• Meloxicam
• Memantine
• Mepenzolate
• Meperidine
• Meperidine; Promethazine
• Mequinol; Tretinoin
• Mestranol; Norethindrone
• Metaproterenol
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methamphetamine
• Methazolamide
• Methenamine
• Methenamine; Sodium Acid Phosphate
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methohexital
• Methotrexate
• Methoxsalen
• Methscopolamine
• Methylphenidate
• Metoclopramide
• Midodrine
• Miglitol
• Milnacipran
• Milrinone
• Mirtazapine
• Mivacurium
• Moexipril
• Morphine
• Morphine; Naltrexone
• Nabumetone
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Nateglinide
• Nebivolol; Valsartan
• Nefazodone
• Nesiritide, BNP
• Neuromuscular blockers
• Niacin, Niacinamide
• Niacin; Simvastatin
• Nitrates
• Nitroglycerin
• Nitroprusside
• Non-Ionic Contrast Media
• Nonsteroidal antiinflammatory drugs
• Norepinephrine
• Octreotide
• Olanzapine
• Olmesartan
• Olodaterol
• Omeprazole
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Ondansetron
• Oprelvekin, rh-IL-11
• Oxaprozin
• Oxybutynin
• Oxycodone
• Oxymetazoline
• Oxymorphone
• Paliperidone
• Pancuronium
• Pantoprazole
• Paroxetine
• Pasireotide
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentoxifylline
• Perindopril
• Perindopril; Amlodipine
• Phendimetrazine
• Phenelzine
• Phenothiazines
• Phentermine
• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Photosensitizing agents (topical)
• Pimozide
• Pioglitazone
• Pirbuterol
• Piroxicam
• Polycarbophil
• Polyethylene Glycol; Electrolytes
• Polyethylene Glycol; Electrolytes; Ascorbic Acid
• Porfimer
• Potassium
• Potassium Phosphate
• Potassium Phosphate; Sodium Phosphate
• Pramlintide
• Prazosin
• Pregabalin
• Prilocaine; Epinephrine
• Probenecid
• Procainamide
• Procaine
• Propantheline
• Propofol
• Pseudoephedrine
• Quetiapine
• Quinapril
• Quinidine
• Rabeprazole
• Ramipril
• Rapacuronium
• Rasagiline
• Remifentanil
• Repaglinide
• Risperidone
• Rocuronium
• Rofecoxib
• Rosiglitazone
• Sacubitril; Valsartan
• Salicylates
• Salmeterol
• Saxagliptin
• Scopolamine
• Selegiline
• Semaglutide
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• Sertraline
• Sevoflurane
• SGLT2 Inhibitors
• Silodosin
• Simvastatin; Sitagliptin
• Sirolimus
• Sitagliptin
• Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Solifenacin
• Spironolactone
• Streptozocin
• Succinylcholine
• Sufentanil
• Sulfacetamide
• Sulfacetamide; Sulfur
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• Sulfinpyrazone
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• Sulindac
• Tacrolimus
• Tapentadol
• Tazarotene
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• Tolvaptan
• Topiramate
• Toremifene
• Tramadol
• Trandolapril
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• Triamterene
• Trihexyphenidyl
• Trimethoprim
• Trospium
• Tubocurarine
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• Valdecoxib
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• Vecuronium
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• Verteporfin
• Vilazodone
• Vitamin D
• Vitamin D analogs
• Vorinostat
• Vortioxetine
• Yohimbine
• Ziconotide
• Ziprasidone