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Hydrochlorothiazide Methyldopa Brand Names- Aldoril | Aldoril D
What is Hydrochlorothiazide Methyldopa
Hydrochlorothiazide and methyldopa are used together in an oral preparation for the treatment of hypertension.
Hydrochlorothiazide is a commonly used thiazide diuretic. Methyldopa is a centrally acting antiadrenergic agent, with declining use due to the development of other antihypertensive agents with a more favorable adverse effect profile.
The extent of blood pressure reduction with the combination of hydrochlorothiazide and methyldopa is additive. Hydrochlorothiazide; methyldopa is not indicated for initial treatment of hypertension (black box warning). The dosage must be individualized by titration of the individual components.
The combination product may be used once the patient has been successfully titrated and the optimal dose corresponds to a ratio contained in the combination formulation. The use, however, of this combination product should be minimal due to dosing constraints from each individual component found in the combination product.
Hydrochlorothiazide doses greater than 50 mg/day should be avoided, so only those patients whose blood pressure is maintained with daily doses of methyldopa equal to or less than 500 mg can be treated with the combination product.
Although methyldopa is the drug used most often in the treatment of chronic hypertension in pregnant women, many experts consider hydrochlorothiazide contraindicated in pregnancy, thereby negating the use of this combination product in pregnancy.
Hydrochlorothiazide methyldopa (Aldoril®) was granted final FDA approval for the treatment of hypertension on January 23, 1986.
Indications
- hypertension
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- amenorrhea
- anaphylactoid reactions
- angina
- anorexia
- aplastic anemia
- arthralgia
- asthenia
- azotemia
- blurred vision
- bradycardia
- breast enlargement
- cholestasis
- choreoathetosis
- cirrhosis
- colitis
- constipation
- depression
- diarrhea
- dizziness
- drowsiness
- edema
- ejaculation dysfunction
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- exfoliative dermatitis
- fever
- flatulence
- galactorrhea
- glycosuria
- gout
- gynecomastia
- headache
- heart failure
- hemolysis
- hemolytic anemia
- hepatic necrosis
- hepatitis
- hyperbilirubinemia
- hypercalcemia
- hypercholesterolemia
- hyperglycemia
- hyperkeratosis
- hyperprolactinemia
- hypertriglyceridemia
- hyperuricemia
- hypochloremia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypotension
- hypovolemia
- impotence (erectile dysfunction)
- interstitial nephritis
- jaundice
- leukopenia
- libido decrease
- lupus-like symptoms
- metabolic alkalosis
- myalgia
- myocarditis
- myopia
- nasal congestion
- nausea
- nightmares
- nocturia
- ocular hypertension
- orgasm dysfunction
- orthostatic hypotension
- pancreatitis
- paresthesias
- pericarditis
- photosensitivity
- pneumonitis
- polyuria
- psychosis
- pulmonary edema
- purpura
- rash
- renal failure (unspecified)
- restlessness
- sialadenitis
- Stevens-Johnson syndrome
- syncope
- thrombocytopenia
- tongue discoloration
- toxic epidermal necrolysis
- urticaria
- vasculitis
- vertigo
- vomiting
- weakness
- xanthopsia
- xerostomia
Monitoring Parameters
- blood glucose
- blood pressure
- Coombs’ test
- heart rate
- hemoglobin/hematocrit
- LFTs
- red blood cell count (RBC)
- serum calcium
- serum creatinine/BUN
- serum electrolytes
- serum magnesium
- serum uric acid
Contraindications
- acid/base imbalance
- anuria
- asthma
- autoimmune disease
- breast-feeding
- cardiac disease
- cerebrovascular disease
- depression
- diabetes mellitus
- dialysis
- diarrhea
- driving or operating machinery
- electrolyte imbalance
- geriatric
- gout
- hemolytic anemia
- hepatic disease
- hepatitis
- hyperaldosteronism
- hypercalcemia
- hyperparathyroidism
- hyperuricemia
- hypochloremia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypotension
- hypovolemia
- initial treatment
- jaundice
- MAOI therapy
- mental status changes
- metabolic alkalosis
- orthostatic hypotension
- pancreatitis
- Parkinson’s disease
- penicillin hypersensitivity
- pheochromocytoma
- preeclampsia
- pregnancy
- renal disease
- renal failure
- renal impairment
- sulfonamide hypersensitivity
- sunlight (UV) exposure
- sympathectomy
- systemic lupus erythematosus (SLE)
- thiazide diuretic hypersensitivity
- vomiting
Interactions
- Acarbose
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetazolamide
- Acetohexamide
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alemtuzumab
- Alendronate; Cholecalciferol
- Alfentanil
- Allopurinol
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Alprazolam
- Alprostadil
- Amifostine
- Aminolevulinic Acid
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Amyl Nitrite
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Apomorphine
- Apraclonidine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atracurium
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Benztropine
- Beta-agonists
- Bortezomib
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Cabergoline
- Calcium
- Calcium Phosphate, Supersaturated
- Calcium; Vitamin D
- Canagliflozin
- Canagliflozin; Metformin
- Cannabidiol
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carbonic anhydrase inhibitors
- Cardiac glycosides
- Cariprazine
- Celecoxib
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorpropamide
- Cholestyramine
- Cidofovir
- Cisapride
- Cisatracurium
- Citalopram
- Clindamycin; Tretinoin
- Clonazepam
- Clorazepate
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- Colestipol
- COMT inhibitors
- Conivaptan
- Corticosteroids
- Cosyntropin
- Cyclophosphamide
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Degarelix
- Desloratadine; Pseudoephedrine
- Desvenlafaxine
- Deutetrabenazine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexlansoprazole
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diazoxide
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Dicyclomine
- Diethylpropion
- Diflunisal
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dofetilide
- Dolasetron
- Donepezil; Memantine
- Dopamine
- Doxacurium
- Droperidol
- Dulaglutide
- Duloxetine
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Entacapone
- Ephedrine
- Epinephrine
- Epoprostenol
- Ergocalciferol, Vitamin D2
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Escitalopram
- Esketamine
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethanol
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Etodolac
- Etomidate
- Exenatide
- Famotidine; Ibuprofen
- Fenfluramine
- Fenoprofen
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Flavoxate
- Fluconazole
- Fluocinolone; Hydroquinone; Tretinoin
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Flurbiprofen
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fospropofol
- Gabapentin
- Gallium Ga 68 Dotatate
- General anesthetics
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Halobetasol; Tazarotene
- Halofantrine
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibuprofen
- Ibuprofen lysine
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Icosapent ethyl
- Iloperidone
- Iloprost
- Inamrinone
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indomethacin
- Inotersen
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Intravenous Lipid Emulsions
- Iron
- Iron Salts
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Ketamine
- Ketoprofen
- Ketorolac
- Lansoprazole
- Lansoprazole; Naproxen
- Lasmiditan
- Lemborexant
- Lesinurad; Allopurinol
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levocetirizine
- Levodopa
- Levomethadyl
- Levomilnacipran
- Levorphanol
- Linagliptin
- Linagliptin; Metformin
- Linezolid
- Liraglutide
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lixisenatide
- Lofexidine
- Loop diuretics
- Loratadine; Pseudoephedrine
- Lorazepam
- Lovastatin; Niacin
- Lumateperone
- Lurasidone
- Magnesium Salts
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Mannitol
- Maprotiline
- Meclofenamate Sodium
- Mefenamic Acid
- Meglitinides
- Meloxicam
- Memantine
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mequinol; Tretinoin
- Mesoridazine
- Mestranol; Norethindrone
- Metaproterenol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methamphetamine
- Methazolamide
- Methenamine
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methotrexate
- Methoxsalen
- Methscopolamine
- Methylphenidate
- Metoclopramide
- Midazolam
- Midodrine
- Miglitol
- Milnacipran
- Milrinone
- Mirtazapine
- Mivacurium
- Moexipril
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nefazodone
- Nesiritide, BNP
- Neuromuscular blockers
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Norepinephrine
- Octreotide
- Olanzapine
- Olodaterol
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Opiate Agonists
- Oprelvekin, rh-IL-11
- Oxaprozin
- Oxazepam
- Oxybutynin
- Oxycodone
- Oxymetazoline
- Oxymorphone
- Paliperidone
- Pancuronium
- Pantoprazole
- Paroxetine
- Pasireotide
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentoxifylline
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phendimetrazine
- Phenelzine
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Photosensitizing agents (topical)
- Pimozide
- Pioglitazone
- Pirbuterol
- Piroxicam
- Polycarbophil
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Polysaccharide-Iron Complex
- Porfimer
- Potassium Phosphate; Sodium Phosphate
- Pramlintide
- Prazosin
- Pregabalin
- Prilocaine; Epinephrine
- Probenecid
- Procainamide
- Procaine
- Prochlorperazine
- Promethazine
- Propantheline
- Propofol
- Propoxyphene
- Pseudoephedrine
- Quazepam
- Quetiapine
- Quinapril
- Quinidine
- Rabeprazole
- Ramipril
- Rapacuronium
- Rasagiline
- Remifentanil
- Repaglinide
- Riluzole
- Risperidone
- Rocuronium
- Rofecoxib
- Rosiglitazone
- Salicylates
- Salmeterol
- Saxagliptin
- Scopolamine
- Selegiline
- Semaglutide
- Serotonin norepinephrine reuptake inhibitors
- Sertraline
- Sevoflurane
- Silodosin
- Simvastatin; Sitagliptin
- Sitagliptin
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Streptozocin
- Succinylcholine
- Sufentanil
- Sulfacetamide
- Sulfacetamide; Sulfur
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfinpyrazone
- Sulfonylureas
- Sulindac
- Tapentadol
- Tazarotene
- Tegaserod
- Temazepam
- Terbutaline
- Tetrabenazine
- Tetracaine
- Thiazolidinediones
- Thiethylperazine
- Thioridazine
- Thiothixene
- Tiotropium; Olodaterol
- Tizanidine
- Tolazamide
- Tolbutamide
- Tolcapone
- Tolmetin
- Tolterodine
- Tolvaptan
- Topiramate
- Toremifene
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Triptorelin
- Trospium
- Tubocurarine
- Umeclidinium; Vilanterol
- Valdecoxib
- Vasopressin, ADH
- Vecuronium
- Venlafaxine
- Verteporfin
- Vilazodone
- Vincristine Liposomal
- Vitamin D
- Vitamin D analogs
- Vorinostat
- Vortioxetine
- Yohimbine
- Ziconotide
- Ziprasidone
