How should a clinician proceed if one NSAID fails to provide sufficient pain relief?
If an adequate trial of one class of NSAID does not cause analgesia, the clinician should switch to an alternative class of NSAID. For example, if an agent from a salicylate group is considered ineffective, it is recommended to change to a proprionic or indole group. On the other hand, when one group of NSAID is effective but produces intolerable side effects, the clinician should first search for another agent in the same class before switching to another group of NSAIDs.