Who is at risk for NSAID induced gastroduodenal ulcer disease

Who is at risk for NSAID induced gastroduodenal ulcer disease?

  • Older age (>65–70 years; relative risk [RR] 5–6× increased).
  • Multiple NSAIDs (including ASA; RR 9×).
  • History of peptic ulcer disease, with or without NSAIDs (RR 6×).
  • Higher dose, prolonged use of NSAIDs (RR 7×).
  • Chronic disease status such as rheumatoid arthritis, chronic obstructive pulmonary disease, coronary artery disease (CAD), diabetes.
  • Concomitant corticosteroid (prednisone ≥10 mg/day; RR 2×), warfarin (RR 6×), clopidogrel, or low-dose ASA.
  • Suspected risk factors: tobacco, alcohol, existing infection with Helicobacter pylori (RR 3–4×).
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