Which organ fails due to high dose methotrexate
Systemic therapy of high-dose methotrexate is associated with failure of which organ?
Renal failure can be seen during treatment with high-dose methotrexate. Patients should be given aggressive hydration, urinary alkalinization, and leucovorin rescue when treated with high-dose methotrexate.
Additionally, glucarpidase was recently approved as a rescue treatment of toxic methotrexate plasma concentrations in patients with delayed methotrexate clearance due to impaired renal function.
