Homatropine Hydrocodone

Homatropine Hydrocodone Brand Names

Hycodan | Hydromet | Hydropane | Mycodone | Tussigon

What is Homatropine Hydrocodone

Homatropine and hydrocodone are used together in an oral preparation as an antitussive for cough relief.

Hydrocodone is a semisynthetic opiate agonist antitussive and is similar in activity to other phenanthrene derivatives such as codeine.

Homatropine, an anticholinergic agent, is included in subtherapeutic amounts in hydrocodone antitussive products to discourage abuse and deliberate overdosage.

Opioid cough and cold medicines that contain hydrocodone are not indicated for pediatric patients under 18 years of age.

The products are contraindicated in neonates, infants and children less than 6 years of age; the risks of these medicines outweigh their benefits in patients younger than 18 years.

Indications

• cough

For cough suppression

Side Effects

1. abdominal pain
2. adrenocortical insufficiency
3. agitation
4. amenorrhea
5. anaphylactoid reactions
6. anxiety
7. arthralgia
8. ataxia
9. back pain
10. biliary obstruction
11. bladder spasm
12. blurred vision
13. bronchial secretions
14. chest pain (unspecified)
15. coma
16. confusion
17. constipation
18. cough
19. cyanosis
20. depression
21. diplopia
22. dizziness
23. drowsiness
24. dyskinesia
25. dyspepsia
26. dysphagia
27. dysphoria
28. dyspnea
29. emotional lability
30. euphoria
31. fatigue
32. flushing
33. gastroesophageal reflux
34. GI obstruction
35. hallucinations
36. headache
37. hot flashes
38. hyperamylasemia
39. hyperhidrosis
40. hypotension
41. ileus
42. impaired cognition
43. impotence (erectile dysfunction)
44. increased intracranial pressure
45. infection
46. infertility
47. insomnia
48. lethargy
49. libido decrease
50. migraine
51. miosis
52. muscle cramps
53. nasal congestion
54. nasal dryness
55. nausea
56. neonatal opioid withdrawal syndrome
57. neonatal respiratory depression
58. orthostatic hypotension
59. palpitations
60. pancreatitis
61. peripheral edema
62. peripheral vasodilation
63. pharyngitis
64. physiological dependence
65. pruritus
66. psychological dependence
67. psychomotor impairment
68. pulmonary edema
69. QT prolongation
70. rash
71. respiratory arrest
72. respiratory depression
73. restlessness
74. seizures
75. serotonin syndrome
76. sinus tachycardia
77. sinusitis
78. syncope
79. tinnitus
80. tolerance
81. tremor
82. urinary retention
83. urticaria
84. vertigo
85. vomiting
86. wheezing
87. withdrawal
88. xerophthalmia
89. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• accidental exposure
• acute abdomen
• adrenal insufficiency
• alcoholism
• asthma
• biliary tract disease
• bladder obstruction
• brain tumor
• breast-feeding
• cardiac disease
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• coadministration with other CNS depressants
• coma
• constipation
• cor pulmonale
• dehydration
• depression
• diarrhea
• driving or operating machinery
• ethanol ingestion
• ethanol intoxication
• gallbladder disease
• geriatric
• GI disease
• GI obstruction
• head trauma
• hepatic disease
• hypotension
• hypothyroidism
• hypovolemia
• hypoxemia
• ileus
• increased intracranial pressure
• infants
• inflammatory bowel disease
• labor
• myxedema
• neonatal opioid withdrawal syndrome
• neonates
• neuromuscular disease
• obesity
• obstetric delivery
• opiate agonist hypersensitivity
• orthostatic hypotension
• pancreatitis
• potential for overdose or poisoning
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• renal failure
• renal impairment
• respiratory depression
• respiratory insufficiency
• scoliosis
• seizure disorder
• seizures
• shock
• sleep apnea
• status asthmaticus
• substance abuse
• syncope
• ulcerative colitis
• urethral stricture
• urinary retention

Interactions

• Abiraterone
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Aclidinium
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Almotriptan
• Alosetron
• Alprazolam
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Alvimopan
• Amantadine
• Ambenonium Chloride
• Amide local anesthetics
• Amifampridine
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amiodarone
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamines
• Antacids
• Anticholinergics
• Apalutamide
• Apomorphine
• Apraclonidine
• Aprepitant, Fosaprepitant
• Aripiprazole
• Armodafinil
• Artemether; Lumefantrine
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Oxycodone
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol; Chlorthalidone
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzonatate
• Benzphetamine
• Benztropine
• Bethanechol
• Bexarotene
• Bicalutamide
• Bisacodyl
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Boceprevir
• Bosentan
• Botulinum Toxins
• Brexpiprazole
• Brigatinib
• Brimonidine
• Brimonidine; Brinzolamide
• Brimonidine; Timolol
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Bumetanide
• Bupivacaine
• Bupivacaine Liposomal
• Bupivacaine; Lidocaine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capsaicin; Metaxalone
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
• Carisoprodol
• Castor Oil
• Celecoxib
• Cenobamate
• Ceritinib
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexbrompheniramine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chloral Hydrate
• Chloramphenicol
• Chlorcyclizine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroprocaine
• Chlorothiazide
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Cholinergic agonists
• Cimetidine
• Cinacalcet
• Ciprofloxacin
• Cisapride
• Citalopram
• Clarithromycin
• Clemastine
• Clobazam
• Clonazepam
• Clonidine
• Clopidogrel
• Clorazepate
• Clozapine
• Cobicistat
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Conivaptan
• Crizotinib
• Crofelemer
• Cyclizine
• Cyclobenzaprine
• Cyclosporine
• Cyproheptadine
• Dabrafenib
• Dacomitinib
• Dalfopristin; Quinupristin
• Danazol
• Dantrolene
• Darifenacin
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Deferasirox
• Delavirdine
• Desflurane
• Desmopressin
• Desvenlafaxine
• Deutetrabenazine
• Dexamethasone
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmedetomidine
• Dexpanthenol
• Dextroamphetamine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Dicyclomine
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Dimenhydrinate
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disopyramide
• Dolasetron
• Donepezil
• Donepezil; Memantine
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Duloxetine
• Duvelisib
• Edrophonium
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix
• Elagolix; Estradiol; Norethindrone acetate
• Elbasvir; Grazoprevir
• Eletriptan
• Elexacaftor; tezacaftor; ivacaftor
• Eliglustat
• Eltrombopag
• Eluxadoline
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Enzalutamide
• Eprosartan; Hydrochlorothiazide, HCTZ
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esketamine
• Eslicarbazepine
• Estazolam
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Etomidate
• Etravirine
• Everolimus
• Ezogabine
• Fedratinib
• Fenfluramine
• Fentanyl
• Fesoterodine
• Flavoxate
• Flibanserin
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Flutamide
• Fluticasone; Umeclidinium; Vilanterol
• Fluvoxamine
• Fosamprenavir
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Fospropofol
• Fostamatinib
• Frovatriptan
• Furosemide
• Gabapentin
• Galantamine
• General anesthetics
• Glucagon
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Glycopyrronium
• Granisetron
• grapefruit juice
• Guanabenz
• Guanfacine
• Haloperidol
• Halothane
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydromorphone
• Hydroxyzine
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Idelalisib
• Iloperidone
• Imatinib
• Indacaterol; Glycopyrrolate
• Indapamide
• Indinavir
• Ipratropium
• Isavuconazonium
• Isocarboxazid
• Isoflurane
• Isoniazid, INH
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Istradefylline
• Itraconazole
• Ivacaftor
• Ketamine
• Ketoconazole
• Lactulose
• Lapatinib
• Larotrectinib
• Lasmiditan
• Lefamulin
• Lemborexant
• Lesinurad
• Lesinurad; Allopurinol
• Letermovir
• Levobupivacaine
• Levocetirizine
• Levomilnacipran
• Levorphanol
• Lidocaine
• Lidocaine; Prilocaine
• Linaclotide
• Lincosamides
• Linezolid
• Lisdexamfetamine
• Lithium
• Lofexidine
• Loop diuretics
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Lorazepam
• Lorcaserin
• Lorlatinib
• Loxapine
• Lubiprostone
• Lumacaftor; Ivacaftor
• Lumacaftor; Ivacaftor
• Lumateperone
• Lurasidone
• Macimorelin
• Magnesium Citrate
• Magnesium Hydroxide
• Magnesium Salts
• Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
• Maprotiline
• Meclizine
• Melatonin
• Memantine
• Mepenzolate
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Mepivacaine
• Mepivacaine; Levonordefrin
• Meprobamate
• Metaxalone
• Methacholine
• Methadone
• Methamphetamine
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methocarbamol
• Methohexital
• Methscopolamine
• Methyclothiazide
• Methyldopa
• Methylene Blue
• Methylphenidate
• Metoclopramide
• Metolazone
• Metyrapone
• Metyrosine
• Midazolam
• Mifepristone
• Milnacipran
• Mineral Oil
• Minocycline
• Mirabegron
• Mirtazapine
• Mitotane
• Modafinil
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nafcillin
• Nalbuphine
• Naloxone
• Naltrexone
• Naproxen; Sumatriptan
• Naratriptan
• Nefazodone
• Nelfinavir
• Neostigmine
• Nesiritide, BNP
• Netupitant, Fosnetupitant; Palonosetron
• Nevirapine
• Nicardipine
• Nilotinib
• Nitrofurantoin
• Nitroglycerin
• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Ondansetron
• Oritavancin
• Orphenadrine
• Osilodrostat
• Oxazepam
• Oxcarbazepine
• Oxybutynin
• Oxycodone
• Oxymorphone
• Ozanimod
• Palbociclib
• Paliperidone
• Palonosetron
• Panobinostat
• Papaverine
• Paroxetine
• Pazopanib
• Peginterferon Alfa-2b
• Pegvisomant
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phentermine; Topiramate
• Phenylephrine; Promethazine
• Phenytoin
• Physostigmine
• Pimozide
• Polyethylene Glycol
• Polyethylene Glycol; Electrolytes
• Polyethylene Glycol; Electrolytes; Ascorbic Acid
• Polyethylene Glycol; Electrolytes; Bisacodyl
• Posaconazole
• Potassium
• Pramipexole
• Pramlintide
• Prasugrel
• Pregabalin
• Prilocaine
• Prilocaine; Epinephrine
• Primidone
• Procainamide
• Procaine
• Prochlorperazine
• Promethazine
• Propafenone
• Propantheline
• Propofol
• Propoxyphene
• Proton pump inhibitors
• Pyridostigmine
• Quazepam
• Quetiapine
• Quinidine
• Quinine
• Ramelteon
• Ranolazine
• Rasagiline
• Remifentanil
• Revefenacin
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifapentine
• Rifaximin
• Risperidone
• Ritonavir
• Rivastigmine
• Rizatriptan
• Rolapitant
• Ropinirole
• Ropivacaine
• Rotigotine
• Rucaparib
• Safinamide
• Saquinavir
• Scopolamine
• Secobarbital
• Secretin
• Sedating H1-blockers
• Selegiline
• Selpercatinib
• Serotonin-Receptor Agonists
• Serotonin-Receptor Antagonists
• Sertraline
• Sevoflurane
• Sibutramine
• Sildenafil
• Simeprevir
• Sincalide
• Skeletal Muscle Relaxants
• Sodium Bicarbonate
• Sodium Oxybate
• Solifenacin
• Sorbitol
• Spironolactone
• St. John’s Wort, Hypericum perforatum
• Streptogramins
• Sufentanil
• Sumatriptan
• Suvorexant
• Tacrine
• Tapentadol
• Tasimelteon
• Tazemetostat
• Tedizolid
• Tegaserod
• Telaprevir
• Telithromycin
• Telotristat Ethyl
• Temazepam
• Terbinafine
• Tetrabenazine
• Tetracaine
• Tezacaftor; Ivacaftor
• Thalidomide
• Thiazide diuretics
• Thiopental
• Thioridazine
• Thiothixene
• Ticagrelor
• Tiotropium
• Tiotropium; Olodaterol
• Tipranavir
• Tizanidine
• Tolterodine
• Topiramate
• Torsemide
• Tramadol
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
• Triamterene
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trihexyphenidyl
• Trimethobenzamide
• Triprolidine
• Trospium
• Tucatinib
• Umeclidinium
• Umeclidinium; Vilanterol
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Vemurafenib
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Voriconazole
• Vortioxetine
• Voxelotor
• Zafirlukast
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolmitriptan
• Zolpidem
• Zonisamide