Homatropine Hydrobromide

Homatropine Hydrobromide Brand Name– Isopto Homatropine

What is Homatropine Hydrobromide

Homatropine hydrobromide is an ophthalmic, cycloplegic mydriatic agent. It is used for cycloplegic refraction and for dilating the pupil in inflammatory conditions of the uveal tract.

It is also used for pre- and postoperative mydriasis, iritis, ciliary spasm, as an aid in axial lens opacities and as a provocative agent in the diagnosis of open-angle glaucoma.

Homatropine is an inferior cycloplegic when compared to ophthalmic atropine or cyclopentolate, particularly in children.

Homatropine has a longer duration of action than tropicamide or cyclopentolate, but a shorter duration than atropine or scopolamine.

Homatropine hydrobromide was approved by the FDA pre-1938.

Indications

  1. cycloplegia induction
  2. iritis
  3. mydriasis induction
  4. uveitis

For mydriasis induction and cycloplegia induction for refraction

Side Effects

  1. agitation
  2. ataxia
  3. blurred vision
  4. bradycardia
  5. coma
  6. confusion
  7. conjunctivitis
  8. contact dermatitis
  9. cycloplegia
  10. delirium
  11. drowsiness
  12. dysarthria
  13. excitability
  14. fever
  15. flushing
  16. hallucinations
  17. mania
  18. mydriasis
  19. ocular hypertension
  20. ocular pain
  21. photophobia
  22. psychosis
  23. rash
  24. restlessness
  25. seizures
  26. sinus tachycardia
  27. urinary retention
  28. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • anticholinergic medications
  • breast-feeding
  • cardiac disease
  • children
  • closed-angle glaucoma
  • contact lenses
  • dementia
  • driving or operating machinery
  • gastroesophageal reflux disease (GERD)
  • geriatric
  • GI obstruction
  • glaucoma
  • hypertension
  • ileus
  • increased intraocular pressure
  • infants
  • neonates
  • open-angle glaucoma
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • synechia
  • ulcerative colitis

Interactions

There are no drug interactions associated with Homatropine Hydrobromide products.