Captopril Hydrochlorothiazide

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Captopril Hydrochlorothiazide Brand Name– Capozide

What is Captopril Hydrochlorothiazide

Captopril and hydrochlorothiazide are used together in an oral preparation to treat hypertension.

Captopril is an angiotensin-converting enzyme inhibitor. Hydrochlorothiazide is a thiazide diuretic.

These ingredients have additive hypotensive activity. Captopril can counter the hypokalemia caused by the hydrochlorothiazide. Captopril is the shortest-acting of the ACE inhibitors, therefore it is usually dosed two or three times a day.

Captopril contains a sulfhydryl group, which may contribute to its pharmacologic action and account for some adverse reactions that occur at higher doses.

All dosage forms of Capozide® were approved by the FDA in October 2004.

Indications

  • hypertension

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. alopecia
  4. anaphylactoid reactions
  5. angina
  6. angioedema
  7. anorexia
  8. anuria
  9. aplastic anemia
  10. arthralgia
  11. azotemia
  12. blurred vision
  13. bronchospasm
  14. chest pain (unspecified)
  15. cholestasis
  16. constipation
  17. cough
  18. diarrhea
  19. dizziness
  20. dysgeusia
  21. dyspepsia
  22. dyspnea
  23. elevated hepatic enzymes
  24. eosinophilia
  25. erythema
  26. exfoliative dermatitis
  27. fatigue
  28. fever
  29. flushing
  30. glomerulonephritis
  31. glossitis
  32. glycosuria
  33. gout
  34. headache
  35. hemolytic anemia
  36. hepatic failure
  37. hepatic necrosis
  38. hepatitis
  39. hyperbilirubinemia
  40. hypercalcemia
  41. hypercholesterolemia
  42. hyperglycemia
  43. hyperkalemia
  44. hypertriglyceridemia
  45. hyperuricemia
  46. hypokalemia
  47. hypomagnesemia
  48. hypophosphatemia
  49. hypotension
  50. hypovolemia
  51. impotence (erectile dysfunction)
  52. interstitial nephritis
  53. jaundice
  54. leukopenia
  55. maculopapular rash
  56. muscle cramps
  57. myalgia
  58. myopia
  59. nausea
  60. nephrolithiasis
  61. nephrotic syndrome
  62. neutropenia
  63. ocular hypertension
  64. oliguria
  65. orthostatic hypotension
  66. palpitations
  67. pancreatitis
  68. pancytopenia
  69. pemphigus
  70. peptic ulcer
  71. photosensitivity
  72. pneumonitis
  73. pruritus
  74. renal failure (unspecified)
  75. renal tubular necrosis
  76. rhinitis
  77. sialadenitis
  78. sinus tachycardia
  79. Stevens-Johnson syndrome
  80. syncope
  81. teratogenesis
  82. thrombocytopenia
  83. toxic epidermal necrolysis
  84. urticaria
  85. vasculitis
  86. visual impairment
  87. vomiting
  88. weakness
  89. xanthopsia
  90. xerostomia

Monitoring Parameters

  • blood glucose
  • blood pressure
  • serum creatinine/BUN
  • serum electrolytes
  • serum uric acid

Contraindications

  • ACE-inhibitor induced angioedema
  • angioedema
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
  • anuria
  • aortic stenosis
  • asthma
  • autoimmune disease
  • Black patients
  • bone marrow suppression
  • breast-feeding
  • cardiomyopathy
  • cerebrovascular disease
  • children
  • coronary artery disease
  • diabetes mellitus
  • dialysis
  • electrolyte imbalance
  • geriatric
  • gout
  • heart failure
  • hepatic disease
  • hereditary angioedema
  • history of angioedema
  • hymenoptera venom (insect sting) allergy desensitization
  • hypercalcemia
  • hyperglycemia
  • hyperkalemia
  • hyperuricemia
  • hypokalemia
  • hypomagnesemia
  • hyponatremia
  • hypovolemia
  • immunosuppression
  • low-density lipoprotein apheresis
  • orthostatic hypotension
  • pancreatitis
  • penicillin hypersensitivity
  • pregnancy
  • renal artery stenosis
  • renal disease
  • renal failure
  • renal impairment
  • scleroderma
  • sulfonamide hypersensitivity
  • sunlight (UV) exposure
  • surgery
  • sympathectomy
  • syncope
  • systemic lupus erythematosus (SLE)
  • thiazide diuretic hypersensitivity

Interactions

  • Acarbose
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acetohexamide
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
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  • Aliskiren
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  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Allopurinol
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
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  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
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  • Amlodipine; Olmesartan
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  • Amlodipine; Valsartan
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  • Amphotericin B cholesteryl sulfate complex (ABCD)
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  • Cardiac glycosides
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  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
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  • Enalapril; Hydrochlorothiazide, HCTZ
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  • Hydrochlorothiazide, HCTZ; Triamterene
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  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen
  • Ibuprofen lysine
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  • Ziprasidone

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