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Flurbiprofen Brand Names- Ansaid | Ocufen
What is Flurbiprofen
Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid chemical class.
The oral formulation is used for the relief of pain and inflammation associated with rheumatoid arthritis and osteoarthritis. Unlabeled uses for oral flurbiprofen include dysmenorrhea and to preserve bone around dental implants.
The longer half-life of flurbiprofen versus ketoprofen or fenoprofen allows for twice daily dosing of flurbiprofen in many patients. All NSAIDs including flurbiprofen cause an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke.
The lowest effective flurbiprofen dose for the shortest possible duration is recommended, as the risk for adverse effects may increase with duration of use.
An ophthalmic form of flurbiprofen (Ocufen®) is available for inhibition of intraoperative miosis and was approved by the FDA in 1986.
Flurbiprofen tablets were approved by the FDA in 1988.
Indications
- ankylosing spondylitis
- arthralgia
- bone pain
- dental implants
- dental pain
- dysmenorrhea
- migraine
- migraine prophylaxis
- mild pain
- miosis inhibition
- moderate pain
- myalgia
- osteoarthritis
- postoperative ocular inflammation
- rheumatoid arthritis
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- amnesia
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- anxiety
- aplastic anemia
- appetite stimulation
- arrhythmia exacerbation
- aseptic meningitis
- asthenia
- ataxia
- blurred vision
- chills
- cholecystitis
- cholestasis
- colitis
- coma
- confusion
- conjunctivitis
- constipation
- corneal opacification
- cystitis
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphagia
- dyspnea
- dysuria
- ecchymosis
- edema
- elevated hepatic enzymes
- emotional lability
- eosinophilia
- epistaxis
- eructation
- erythema multiforme
- esophageal stricture
- esophageal ulceration
- esophagitis
- exfoliative dermatitis
- fever
- flatulence
- foreign body sensation
- gastritis
- GI bleeding
- GI perforation
- glossitis
- hallucinations
- headache
- hearing loss
- heart failure
- hematemesis
- hematuria
- hemolytic anemia
- hepatic failure
- hepatitis
- hyperglycemia
- hyperkalemia
- hyperreflexia
- hypertension
- hypertonia
- hyperuricemia
- hyperventilation
- hyphema
- hyponatremia
- hypotension
- infection
- insomnia
- interstitial nephritis
- jaundice
- laryngitis
- leukopenia
- lymphadenopathy
- malaise
- melena
- meningitis
- menstrual irregularity
- miosis
- myasthenia
- mydriasis
- myocardial infarction
- nausea
- nephrotic syndrome
- ocular irritation
- ocular pain
- odynophagia
- oliguria
- optic neuritis
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- parosmia
- peptic ulcer
- peripheral vasodilation
- photophobia
- photosensitivity
- platelet dysfunction
- polyuria
- prolonged bleeding time
- prostatic hypertrophy
- prostatitis
- proteinuria
- pruritus
- pulmonary embolism
- purpura
- pyrosis (heartburn)
- rash
- renal failure (unspecified)
- renal papillary necrosis
- respiratory depression
- retinal hemorrhage
- rhinitis
- seizures
- sinus tachycardia
- Stevens-Johnson syndrome
- stomatitis
- stroke
- syncope
- thrombocytopenia
- thromboembolism
- tinnitus
- toxic epidermal necrolysis
- tremor
- urticaria
- vaginal bleeding
- vaginitis
- vasculitis
- vertigo
- vomiting
- weight gain
- xerophthalmia
- xerostomia
Monitoring Parameters
- CBC
- LFTs
- serum creatinine/BUN
- stool guaiac
Contraindications
- acute bronchospasm
- acute myocardial infarction
- alcoholism
- anemia
- angina
- anticoagulant therapy
- asthma
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- cerebrovascular disease
- chemotherapy
- coagulopathy
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- corticosteroid therapy
- dental disease
- dental work
- diabetes mellitus
- edema
- geriatric
- GI bleeding
- GI disease
- GI perforation
- heart failure
- hemophilia
- hepatic disease
- hypertension
- immunosuppression
- jaundice
- labor
- myocardial infarction
- nasal polyps
- neutropenia
- NSAID hypersensitivity
- obstetric delivery
- ocular surgery
- peptic ulcer disease
- peripheral vascular disease
- poor metabolizers
- pregnancy
- renal disease
- renal failure
- renal impairment
- rheumatoid arthritis
- salicylate hypersensitivity
- stroke
- surgery
- thrombocytopenia
- thromboembolism
- tobacco smoking
- ulcerative colitis
- urticaria
- visual disturbance
Interactions
- Abciximab
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetohexamide
- Acyclovir
- Adefovir
- Aldesleukin, IL-2
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alpha-blockers
- Alteplase
- Altretamine
- Ambenonium Chloride
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Anagrelide
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Aprepitant, Fosaprepitant
- Aprotinin
- Argatroban
- Arsenic Trioxide
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
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- Azathioprine
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- Azilsartan
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- Benazepril
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- Bendroflumethiazide; Nadolol
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- Beta-blockers
- Betamethasone
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- Eltrombopag
- Elvitegravir
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- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enoxaparin
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- Ethanol
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- Famotidine; Ibuprofen
- Fenofibric Acid
- Fenoldopam
- Fenoprofen
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- Fondaparinux
- food
- Formoterol; Mometasone
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- Gallium Ga 68 Dotatate
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- Garlic, Allium sativum
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- Glimepiride; Pioglitazone
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- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Gold
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- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibuprofen
- Ibuprofen lysine
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloprost
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- Indapamide
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- Ivacaftor
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- Ketoprofen
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