Flurbiprofen

Flurbiprofen Brand Names- Ansaid | Ocufen

What is Flurbiprofen

Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid chemical class.

The oral formulation is used for the relief of pain and inflammation associated with rheumatoid arthritis and osteoarthritis. Unlabeled uses for oral flurbiprofen include dysmenorrhea and to preserve bone around dental implants.

The longer half-life of flurbiprofen versus ketoprofen or fenoprofen allows for twice daily dosing of flurbiprofen in many patients. All NSAIDs including flurbiprofen cause an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke.

The lowest effective flurbiprofen dose for the shortest possible duration is recommended, as the risk for adverse effects may increase with duration of use.

An ophthalmic form of flurbiprofen (Ocufen®) is available for inhibition of intraoperative miosis and was approved by the FDA in 1986.

Flurbiprofen tablets were approved by the FDA in 1988.

Indications

  1. ankylosing spondylitis
  2. arthralgia
  3. bone pain
  4. dental implants
  5. dental pain
  6. dysmenorrhea
  7. migraine
  8. migraine prophylaxis
  9. mild pain
  10. miosis inhibition
  11. moderate pain
  12. myalgia
  13. osteoarthritis
  14. postoperative ocular inflammation
  15. rheumatoid arthritis

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. alopecia
  4. amnesia
  5. anaphylactoid reactions
  6. anemia
  7. angina
  8. angioedema
  9. anorexia
  10. anxiety
  11. aplastic anemia
  12. appetite stimulation
  13. arrhythmia exacerbation
  14. aseptic meningitis
  15. asthenia
  16. ataxia
  17. blurred vision
  18. chills
  19. cholecystitis
  20. cholestasis
  21. colitis
  22. coma
  23. confusion
  24. conjunctivitis
  25. constipation
  26. corneal opacification
  27. cystitis
  28. depression
  29. diaphoresis
  30. diarrhea
  31. dizziness
  32. drowsiness
  33. dysgeusia
  34. dyspepsia
  35. dysphagia
  36. dyspnea
  37. dysuria
  38. ecchymosis
  39. edema
  40. elevated hepatic enzymes
  41. emotional lability
  42. eosinophilia
  43. epistaxis
  44. eructation
  45. erythema multiforme
  46. esophageal stricture
  47. esophageal ulceration
  48. esophagitis
  49. exfoliative dermatitis
  50. fever
  51. flatulence
  52. foreign body sensation
  53. gastritis
  54. GI bleeding
  55. GI perforation
  56. glossitis
  57. hallucinations
  58. headache
  59. hearing loss
  60. heart failure
  61. hematemesis
  62. hematuria
  63. hemolytic anemia
  64. hepatic failure
  65. hepatitis
  66. hyperglycemia
  67. hyperkalemia
  68. hyperreflexia
  69. hypertension
  70. hypertonia
  71. hyperuricemia
  72. hyperventilation
  73. hyphema
  74. hyponatremia
  75. hypotension
  76. infection
  77. insomnia
  78. interstitial nephritis
  79. jaundice
  80. laryngitis
  81. leukopenia
  82. lymphadenopathy
  83. malaise
  84. melena
  85. meningitis
  86. menstrual irregularity
  87. miosis
  88. myasthenia
  89. mydriasis
  90. myocardial infarction
  91. nausea
  92. nephrotic syndrome
  93. ocular irritation
  94. ocular pain
  95. odynophagia
  96. oliguria
  97. optic neuritis
  98. palpitations
  99. pancreatitis
  100. pancytopenia
  101. paresthesias
  102. parosmia
  103. peptic ulcer
  104. peripheral vasodilation
  105. photophobia
  106. photosensitivity
  107. platelet dysfunction
  108. polyuria
  109. prolonged bleeding time
  110. prostatic hypertrophy
  111. prostatitis
  112. proteinuria
  113. pruritus
  114. pulmonary embolism
  115. purpura
  116. pyrosis (heartburn)
  117. rash
  118. renal failure (unspecified)
  119. renal papillary necrosis
  120. respiratory depression
  121. retinal hemorrhage
  122. rhinitis
  123. seizures
  124. sinus tachycardia
  125. Stevens-Johnson syndrome
  126. stomatitis
  127. stroke
  128. syncope
  129. thrombocytopenia
  130. thromboembolism
  131. tinnitus
  132. toxic epidermal necrolysis
  133. tremor
  134. urticaria
  135. vaginal bleeding
  136. vaginitis
  137. vasculitis
  138. vertigo
  139. vomiting
  140. weight gain
  141. xerophthalmia
  142. xerostomia

Monitoring Parameters

  • CBC
  • LFTs
  • serum creatinine/BUN
  • stool guaiac

Contraindications

  • acute bronchospasm
  • acute myocardial infarction
  • alcoholism
  • anemia
  • angina
  • anticoagulant therapy
  • asthma
  • bone marrow suppression
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • cerebrovascular disease
  • chemotherapy
  • coagulopathy
  • coronary artery bypass graft surgery (CABG)
  • coronary artery disease
  • corticosteroid therapy
  • dental disease
  • dental work
  • diabetes mellitus
  • edema
  • geriatric
  • GI bleeding
  • GI disease
  • GI perforation
  • heart failure
  • hemophilia
  • hepatic disease
  • hypertension
  • immunosuppression
  • jaundice
  • labor
  • myocardial infarction
  • nasal polyps
  • neutropenia
  • NSAID hypersensitivity
  • obstetric delivery
  • ocular surgery
  • peptic ulcer disease
  • peripheral vascular disease
  • poor metabolizers
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • rheumatoid arthritis
  • salicylate hypersensitivity
  • stroke
  • surgery
  • thrombocytopenia
  • thromboembolism
  • tobacco smoking
  • ulcerative colitis
  • urticaria
  • visual disturbance

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