Flutamide

Flutamide Brand Name– Eulexin

What is Flutamide

Flutamide is an oral nonsteroidal antiandrogen used as an antihormonal agent in the treatment of metastatic prostatic carcinoma.

The drug is most effective when used simultaneously with LHRH agonists such as leuprolide acetate.

Flutamide is not effective in treating other hormonally dependent diseases such as breast cancer or benign prostatic hypertrophy.

Flutamide was originally approved by the FDA in January 1989 for the treatment of stage D2 metastatic prostate carcinoma. In June 1996, it was subsequently approved for treatment of stages B2 and C, in combination with LHRH agonists.

Indications

  • prostate cancer

For the treatment of prostate cancer

for the treatment of locally confined Stage B2-C and Stage D2 prostate cancer in combination with leuteinizing hormone-releasing hormone (LHRH) analogs and radiation therapy

Side Effects

  1. abdominal pain
  2. anemia
  3. anorexia
  4. anxiety
  5. cholestasis
  6. confusion
  7. depression
  8. diarrhea
  9. diarrhea
  10. drowsiness
  11. edema
  12. elevated hepatic enzymes
  13. fatigue
  14. gynecomastia
  15. hemolytic anemia
  16. hepatic encephalopathy
  17. hepatic failure
  18. hepatic necrosis
  19. hepatitis
  20. hot flashes
  21. hyperbilirubinemia
  22. hypertension
  23. impotence (erectile dysfunction)
  24. jaundice
  25. leukopenia
  26. libido decrease
  27. methemoglobinemia
  28. nausea
  29. new primary malignancy
  30. photosensitivity
  31. rash
  32. thrombocytopenia
  33. urine discoloration
  34. vomiting

Monitoring Parameters

  • CBC
  • LFTs

Contraindications

  • breast-feeding
  • females
  • G6PD deficiency
  • hemoglobinopathy
  • hepatic disease
  • lactase deficiency
  • polycystic ovary syndrome
  • pregnancy
  • tobacco smoking

Interactions

  • Acetaminophen; Hydrocodone
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Aprepitant, Fosaprepitant
  • Articaine; Epinephrine
  • Atazanavir
  • Atazanavir; Cobicistat
  • Boceprevir
  • Bromocriptine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Chloroprocaine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Ciprofloxacin
  • Cobicistat
  • Cobimetinib
  • Daclatasvir
  • Dapsone
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Deflazacort
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dolutegravir; Rilpivirine
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Elbasvir; Grazoprevir
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • food
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibrutinib
  • Idelalisib
  • Isavuconazonium
  • Lidocaine
  • Lidocaine; Prilocaine
  • Loperamide
  • Loperamide; Simethicone
  • Maraviroc
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Mitotane
  • Obeticholic Acid
  • Pazopanib
  • Peginterferon Alfa-2b
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Perindopril; Amlodipine
  • Pexidartinib
  • Posaconazole
  • Praziquantel
  • Prilocaine
  • Prilocaine; Epinephrine
  • Rilpivirine
  • Riluzole
  • Rivaroxaban
  • Romidepsin
  • Ropivacaine
  • Ruxolitinib
  • Simeprevir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Telaprevir
  • Telotristat Ethyl
  • Terbinafine
  • Tetracaine
  • Tolvaptan
  • Trabectedin
  • Ulipristal
  • Vemurafenib
  • Vincristine
  • Vincristine Liposomal
  • Vorapaxar
  • Warfarin