Flurazepam Brand Name– Dalmane
What is Flurazepam
Flurazepam is an oral benzodiazepine used as a hypnotic agent in the short-term management of insomnia.
Prolonged use is less likely to cause rebound insomnia and tolerance to the hypnotic effect than are benzodiazepines with a shorter half-life (e.g., triazolam, oxazepam); however, flurazepam is more likely to cause residual daytime CNS-depressant effects.
Flurazepam was approved by the FDA in 1970.
Indications
- anxiety
- insomnia
For the short-term treatment of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings
Side Effects
- amnesia
- anaphylactoid reactions
- angioedema
- anorexia
- anxiety
- arthralgia
- ataxia
- blurred vision
- chest pain (unspecified)
- complex sleep-related behaviors
- confusion
- constipation
- depression
- diarrhea
- dizziness
- drowsiness
- dysarthria
- dysgeusia
- elevated hepatic enzymes
- euphoria
- fatigue
- flushing
- gastritis
- hallucinations
- headache
- hyperbilirubinemia
- hyperhidrosis
- hypersalivation
- hypotension
- insomnia
- irritability
- leukopenia
- memory impairment
- nausea
- neonatal abstinence syndrome
- neonatal respiratory depression
- nightmares
- ocular irritation
- palpitations
- physiological dependence
- pruritus
- psychological dependence
- pyrosis (heartburn)
- rash
- respiratory depression
- somnambulism
- syncope
- teratogenesis
- tolerance
- tremor
- vertigo
- vomiting
- weakness
- withdrawal
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- alcoholism
- asthma
- benzodiazepine dependence
- benzodiazepine hypersensitivity
- bipolar disorder
- breast-feeding
- bronchitis
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- CNS depression
- coadministration with other CNS depressants
- coma
- complex sleep-related behaviors
- dementia
- depression
- driving or operating machinery
- ethanol ingestion
- ethanol intoxication
- geriatric
- hepatic disease
- infants
- mania
- myasthenia gravis
- neonates
- obstetric delivery
- pain
- Parkinson’s disease
- porphyria
- pregnancy
- psychosis
- pulmonary disease
- renal failure
- renal impairment
- respiratory depression
- seizure disorder
- seizures
- shock
- sleep apnea
- status epilepticus
- substance abuse
- suicidal ideation
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alfentanil
- Alprazolam
- Amiodarone
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Apalutamide
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benztropine
- Boceprevir
- Bosentan
- Brimonidine
- Brimonidine; Brinzolamide
- Brimonidine; Timolol
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butorphanol
- Caffeine
- Caffeine; Ergotamine
- Cannabidiol
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorcyclizine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorthalidone; Clonidine
- Cimetidine
- Ciprofloxacin
- Cisapride
- Clarithromycin
- Clemastine
- Clobazam
- Clonidine
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- COMT inhibitors
- Conivaptan
- Cyclizine
- Cyproheptadine
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desflurane
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dicyclomine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disulfiram
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enflurane
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esketamine
- Eszopiclone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethotoin
- Etomidate
- Fenfluramine
- Fentanyl
- Fluconazole
- Flumazenil
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- food
- Fosamprenavir
- Fosphenytoin
- Fospropofol
- Gabapentin
- General anesthetics
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guanabenz
- Guanfacine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydantoins
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Idelalisib
- Iloperidone
- Imatinib
- Indinavir
- Isavuconazonium
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketamine
- Ketoconazole
- Lasmiditan
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levocetirizine
- Levomethadyl
- Levomilnacipran
- Levorphanol
- Lithium
- Lofexidine
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Magnesium Salts
- Maprotiline
- Meclizine
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Meprobamate
- Mestranol; Norethindrone
- Methadone
- Methocarbamol
- Methscopolamine
- Methyldopa
- Metoclopramide
- Metyrapone
- Metyrosine
- Milnacipran
- Minocycline
- Mirtazapine
- Mitotane
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nefazodone
- Nelfinavir
- Nevirapine
- Nicardipine
- Nilotinib
- Nitroglycerin
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oritavancin
- Oxybutynin
- Oxycodone
- Oxymorphone
- Paliperidone
- Papaverine
- Pazopanib
- Pentazocine
- Pentazocine; Naloxone
- Perampanel
- Phenothiazines
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Pimozide
- Posaconazole
- Pramipexole
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Pregabalin
- Probenecid
- Procarbazine
- Propofol
- Propoxyphene
- Protease inhibitors
- Quetiapine
- Ramelteon
- Ranolazine
- Rasagiline
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Risperidone
- Ritonavir
- Ropinirole
- Rotigotine
- Safinamide
- Saquinavir
- Scopolamine
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Sevoflurane
- Simeprevir
- Sincalide
- Skeletal Muscle Relaxants
- Sodium Oxybate
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Suvorexant
- Tapentadol
- Teduglutide
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Tetrabenazine
- Thalidomide
- Theophylline, Aminophylline
- Thiothixene
- Tiagabine
- Tipranavir
- Tizanidine
- Topiramate
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Tricyclic antidepressants
- Trihexyphenidyl
- Trimethobenzamide
- Triprolidine
- Tucatinib
- Valerian, Valeriana officinalis
- Vemurafenib
- Verapamil
- Vigabatrin
- Vilazodone
- Voriconazole
- Zafirlukast
- Zaleplon
- Zileuton
- Ziprasidone
- Zolpidem
