Fexofenadine Pseudoephedrine

Fexofenadine Pseudoephedrine Brand Names

Allegra-D | Allegra-D 12 Hour Allergy & Congestion | Allegra-D 24 Hour Allergy & Congestion | Antihistamine & Nasal Decongestant

What is Fexofenadine Pseudoephedrine

Fexofenadine and pseudoephedrine are combined in an oral preparation for the relief of seasonal allergic rhinitis symptoms.

Fexofenadine is a non-sedating antihistamine (H1-blocker) that dries nasal and sinus passages; it is the active metabolite of the antihistamine terfenadine.

Fexofenadine generally does not cause QT prolongation when given in doses up to 800 mg/day or when administered concomitantly with ketoconazole or erythromycin. However, a case report documented ventricular tachycardia associated with QT prolongation during fexofenadine therapy in a patient with a history of prolonged QT interval.

Pseudoephedrine is a sympathomimetic decongestant agent.

Fexofenadine pseudoephedrine was first FDA approved in December 1997. In January 2011, the FDA approved the non-prescription (over-the-counter or OTC)  sale of fexofenadine pseudoephedrine in the same strengths, formulations, and indications as available by prescription.

Indications

1. allergic rhinitis
2. common cold
3. nasal congestion
4. rhinorrhea
5. sneezing

For the temporary relief of symptoms due to seasonal allergic rhinitis or the common cold, including sneezing, rhinorrhea, itching of the nose or throat, nasal congestion, and itchy, watery eyes

Side Effects

1. abdominal pain
2. agitation
3. anaphylactoid reactions
4. angina
5. angioedema
6. anorexia
7. anxiety
8. arrhythmia exacerbation
9. back pain
10. colitis
11. dizziness
12. drowsiness
13. dyspepsia
14. dysuria
15. headache
16. hypertension
17. infection
18. insomnia
19. myocardial infarction
20. nausea
21. palpitations
22. photophobia
23. pruritus
24. QT prolongation
25. rash
26. restlessness
27. seizures
28. sinus tachycardia
29. stroke
30. supraventricular tachycardia (SVT)
31. throat irritation
32. tremor
33. urticaria
34. ventricular tachycardia
35. vomiting
36. xerostomia

Monitoring Parameters

• serum creatinine/BUN

Contraindications

• acute myocardial infarction
• angina
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• children
• closed-angle glaucoma
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• geriatric
• heart failure
• hypertension
• hyperthyroidism
• infants
• MAOI therapy
• myocardial infarction
• neonates
• pregnancy
• prostatic hypertrophy
• renal failure
• renal impairment
• tachycardia
• terfenadine hypersensitivity
• urinary retention

Interactions

• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetazolamide
• Aclidinium; Formoterol
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alkalinizing Agents
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amiloride; Hydrochlorothiazide, HCTZ
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Ammonium Chloride
• Amoxapine
• Angiotensin II receptor antagonists
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• Antacids
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• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
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• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azilsartan; Chlorthalidone
• Belladonna Alkaloids; Ergotamine; Phenobarbital
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• Betaxolol
• Bethanechol
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• Bumetanide
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• Cabozantinib
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• Canagliflozin
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• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
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• Carbinoxamine; Phenylephrine
• Cardiac glycosides
• Carteolol
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• Clevidipine
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• Cocaine
• Codeine; Phenylephrine; Promethazine
• Colchicine
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• Desloratadine
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• Empagliflozin; Metformin
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• Enalapril; Hydrochlorothiazide, HCTZ
• Ephedrine
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• Eprosartan; Hydrochlorothiazide, HCTZ
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• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• grapefruit juice
• Green Tea
• Guaifenesin; Phenylephrine
• Guanabenz
• Halogenated Anesthetics
• Haloperidol
• Heparin
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
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• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
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• Hydrocodone; Phenylephrine
• Iloprost
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• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Linagliptin; Metformin
• Linezolid
• Liothyronine
• Liraglutide
• Lisinopril
• Lixisenatide
• Lomitapide
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• Lopinavir; Ritonavir
• Loratadine
• Loratadine; Pseudoephedrine
• Lumacaftor; Ivacaftor
• Macitentan
• Magnesium Hydroxide
• Maprotiline
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• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methazolamide
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• Midodrine
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• Nicotine
• Nifedipine
• Nimodipine
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• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Sodium Bicarbonate
• Ozanimod
• Penbutolol
• Pergolide
• Perindopril
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• Phenylephrine
• Phenylephrine; Promethazine
• Pindolol
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• Pramlintide
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• Quinapril
• Racepinephrine
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• Safinamide
• Salmeterol
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• Sofosbuvir; Velpatasvir; Voxilaprevir
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• Theophylline, Aminophylline
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• Ulipristal
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• Yohimbine