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Fexofenadine Brand Names
Allegra | Allegra Allergy 12 Hour | Allegra Allergy 24 Hour | Allegra Children’s Allergy | Allegra Children’s Allergy ODT | Allegra ODT | Allergy Relief | Children’s Allergy Fexofenadine
What is Fexofenadine
Fexofenadine is a non-sedating antihistamine (H1-receptor antagonist). It is the active metabolite of another H1-antagonist, terfenadine.
Unlike terfenadine, fexofenadine does not generally cause QT prolongation when given in doses up to 800 mg/day or when administered concomitantly with ketoconazole or erythromycin.
However, one case report documented ventricular tachycardia associated with QT prolongation during fexofenadine therapy in a patient with a history of prolonged QT interval.
Fexofenadine (Allegra) was first FDA approved in July 1996 for the treatment of seasonal allergic rhinitis; subsequent approval was granted in February 2000 for a once-daily product and for the treatment of chronic idiopathic urticaria.
Other formulations were similarly approved including an oral liquid in October 2006 and an orally disintegrating tablet in July 2007.
In January 2011, the FDA approved the over-the-counter sale of fexofenadine in the same formulations, strengths, and indications as available by prescription, with the exception that treatment of urticaria in certain pediatric patients
Indications
- allergic rhinitis
- chronic idiopathic urticaria
- perennial allergies
- seasonal allergies
For the management of symptoms of perennial allergies and seasonal allergies, including allergic rhinitis
Side Effects
- anaphylactoid reactions
- angioedema
- back pain
- chest pain (unspecified)
- cough
- diarrhea
- dizziness
- dysmenorrhea
- dyspepsia
- dyspnea
- fatigue
- fever
- flushing
- headache
- infection
- insomnia
- myalgia
- paranoia
- pharyngitis
- pruritus
- rash
- restlessness
- rhinorrhea
- urticaria
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- children
- driving or operating machinery
- geriatric
- infants
- neonates
- phenylketonuria
- pregnancy
- renal disease
- renal failure
- renal impairment
- terfenadine hypersensitivity
Interactions
- Alogliptin; Pioglitazone
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Atazanavir; Cobicistat
- Boceprevir
- Cabozantinib
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Carvedilol
- Cobicistat
- Conivaptan
- Daclatasvir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Desloratadine
- Desloratadine; Pseudoephedrine
- Elexacaftor; tezacaftor; ivacaftor
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Etravirine
- Fosamprenavir
- Fostamatinib
- Glecaprevir; Pibrentasvir
- Glimepiride; Pioglitazone
- grapefruit juice
- Heparin
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ixabepilone
- Ketoconazole
- Ledipasvir; Sofosbuvir
- Lomitapide
- Lopinavir; Ritonavir
- Loratadine
- Loratadine; Pseudoephedrine
- Lumacaftor; Ivacaftor
- Magnesium Hydroxide
- Metformin; Pioglitazone
- Neratinib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Sodium Bicarbonate
- Pioglitazone
- Ponatinib
- Posaconazole
- Rifampin
- Ritonavir
- Sapropterin
- Sincalide
- Sodium Bicarbonate
- Sofosbuvir; Velpatasvir; Voxilaprevir
- St. John’s Wort, Hypericum perforatum
- Telaprevir
- Telithromycin
- Ulipristal
- Vemurafenib
