Fesoterodine Brand Name– Toviaz
What is Fesoterodine
Fesoterodine is a muscarinic receptor antagonist. The active metabolite of fesoterodine is responsible for the therapeutic actions of the drug.
During clinical trials, researchers evaluated the mean change in the number of urge urinary incontinence episodes and the mean change in micturitions per 24 hours.
The mean change in voided volume per micturition was assessed as a secondary measure.
Statistically significant improvements were observed for all parameters in both the fesoterodine 4 mg/day and 8 mg/day groups compared to placebo. A reduction in the number of urge urinary incontinence episodes per 24 hours was observed for both doses compared to placebo as early as 2 weeks after treatment initiation.
On October 31, 2008, the FDA approved fesoterodine (Toviaz™) for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.
Indications
- overactive bladder (OAB)
- urinary incontinence
- urinary urgency
For the treatment of overactive bladder (OAB) with symptoms of urinary incontinence, urinary urgency, and urinary frequency
Side Effects
- abdominal pain
- angina
- angioedema
- back pain
- blurred vision
- chest pain (unspecified)
- constipation
- cough
- dizziness
- drowsiness
- dyspepsia
- dysuria
- elevated hepatic enzymes
- headache
- infection
- insomnia
- nausea
- palpitations
- peripheral edema
- pruritus
- QT prolongation
- rash
- urinary retention
- urticaria
- vomiting
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- ambient temperature increase
- autonomic neuropathy
- breast-feeding
- children
- closed-angle glaucoma
- constipation
- contact lenses
- driving or operating machinery
- ethanol ingestion
- gastroesophageal reflux disease (GERD)
- gastroparesis
- geriatric
- GI obstruction
- hepatic disease
- ileus
- infants
- myasthenia gravis
- pregnancy
- prostatic hypertrophy
- pyloric stenosis
- renal failure
- renal impairment
- toxic megacolon
- ulcerative colitis
- urinary retention
- urinary tract obstruction
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Alfentanil
- Amantadine
- Amiodarone
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Belladonna; Opium
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Caffeine
- Caffeine; Ergotamine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cimetidine
- Cisapride
- Clarithromycin
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Fentanyl
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Fosamprenavir
- grapefruit juice
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Imatinib
- Indinavir
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Levorphanol
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Maprotiline
- Meperidine
- Meperidine; Promethazine
- Methadone
- Mirabegron
- Morphine
- Morphine; Naltrexone
- Nefazodone
- Nelfinavir
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Opiate Agonists
- Orphenadrine
- Oxycodone
- Oxymorphone
- Propoxyphene
- Protease inhibitors
- Quetiapine
- Quinine
- Ranolazine
- Remifentanil
- Rifampin
- Ritonavir
- Saquinavir
- Sufentanil
- Telaprevir
- Tipranavir
- Trandolapril; Verapamil
- Verapamil
- Voriconazole
- Zafirlukast
