Etomidate Brand Name– Amidate
What is Etomidate
Etomidate is a short-acting, intravenous sedative-hypnotic without analgesic activity.
It is used for the induction and maintenance of general anesthesia during short procedures, and as an adjunct to low-potency anesthetics such as nitrous oxide.
Etomidate has a rapid onset of action and recovery.
Etomidate causes minimal cardiovascular depression and less hypertension when compared to equipotent doses of thiopental.
It also causes no histamine release, so etomidate is useful in patients with compromised cardiopulmonary function.
Indications
- general anesthesia induction
- general anesthesia maintenance
- obstetric anesthesia
- procedural sedation
- rapid-sequence intubation
Side Effects
- adrenocortical insufficiency
- anaphylactoid reactions
- apnea
- arrhythmia exacerbation
- bradycardia
- hiccups
- hypertension
- hyperventilation
- hypoaldosteronism
- hypotension
- hypoventilation
- injection site reaction
- laryngospasm
- myoclonia
- nausea
- respiratory depression
- sinus tachycardia
- tachypnea
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- children
- driving or operating machinery
- esophageal varices
- geriatric
- hepatic disease
- hypertension
- hypovolemia
- infants
- intraarterial administration
- labor
- neonates
- obstetric delivery
- pregnancy
- renal impairment
- sepsis
- shock
- trauma
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Ambrisentan
- Amikacin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxapine
- Amphetamine; Dextroamphetamine Salts
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Apomorphine
- Apraclonidine
- Articaine; Epinephrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Bacitracin
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzphetamine
- Beta-adrenergic blockers
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Calcium-channel blockers
- Cannabidiol
- Capreomycin
- Capsaicin; Metaxalone
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carisoprodol
- Cenobamate
- Central-acting adrenergic agents
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorcyclizine
- Chloroprocaine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorzoxazone
- Cholinesterase inhibitors
- Clemastine
- Clobazam
- Clomipramine
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dantrolene
- Desipramine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doxazosin
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Dyphylline
- Dyphylline; Guaifenesin
- Epinephrine
- Eplerenone
- Epoprostenol
- Esketamine
- Eszopiclone
- Fenfluramine
- Fentanyl
- Fluphenazine
- Gabapentin
- Gentamicin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Iloprost
- Imipramine
- Ionic Contrast Media
- Kanamycin
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levomethadyl
- Levorphanol
- Lidocaine; Prilocaine
- Lisdexamfetamine
- Lofexidine
- Loop diuretics
- Loxapine
- Lumateperone
- Magnesium Salts
- Maprotiline
- Mecamylamine
- Meclizine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mesoridazine
- Metaxalone
- Methadone
- Methamphetamine
- Methohexital
- Minocycline
- Mirtazapine
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nesiritide, BNP
- Nortriptyline
- Orphenadrine
- Oxycodone
- Oxymorphone
- Oxytocin
- Papaverine
- Pentobarbital
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenoxybenzamine
- Polymyxin B
- Polymyxins
- Potassium-sparing diuretics
- Prazosin
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Procaine
- Procarbazine
- Prochlorperazine
- Propofol
- Propoxyphene
- Protriptyline
- Rasagiline
- Remifentanil
- Reserpine
- Ritodrine
- Secobarbital
- Sedating H1-blockers
- Sodium Oxybate
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Streptomycin
- Sufentanil
- Suvorexant
- Tapentadol
- Terazosin
- Tetracaine
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Tobramycin
- Tramadol
- Treprostinil
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triprolidine
- Trovafloxacin, Alatrofloxacin
- Vancomycin
- Vasodilators
- Zaleplon
- Zolpidem
