Etonogestrel

Etonogestrel Brand Names- Implanon | Nexplanon

What is Etonogestrel

Etonogestrel is a synthetic progestin that is the active metabolite of the prodrug desogestrel.

The etonogestrel implant is a contraceptive device consisting of a single sterile rod for subdermal placement in the upper arm; the implant is designed to release etonogestrel over a 3-year period.

The etonogestrel implant is unique among the progestin-only contraceptives because it provides long-acting, high contraceptive efficacy (cumulative Pearl Index of 0.38 pregnancies per 100 women-years of use) that also allows a rapid return to fertility after removal.

Etonogestrel subdermal implants are available only for use by physicians who undergo specialized training for device insertion and removal. Progestin-only contraceptives can be used in female patients from menarche to over the age of 40 years and up until the time of menopause with the proper selection of products.

The choice of a routine hormonal contraceptive for any given patient is based on the individual’s contraceptive needs, underlying medical conditions or risk factors for adverse effects, and individual preferences for use.

The Centers for Disease Control’s U.S. Medical Eligibility Criteria describe considerations for risk vs. benefits, including medical conditions or attributes that contraindicate use; these criteria can help prescribing practitioners in product selection for individual patients.

Etonogestrel has been used off-label for the medical management of endometriosis and endometriosis-related pain in women who also desire contraception.

An etonogestrel implant (Implanon) was initially approved by the FDA in 2006 but was removed from the U.S. market in 2015 after Nexplanon was FDA approved to replace it in 2011.

Nexplanon, which is bioequivalent to Implanon, has a pre-loaded applicator designed to reduce the risk of insertion errors and is a radiopaque device to allow for localization via standard imaging procedures to confirm placement.

Indications

  • contraception
  • endometriosis

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. alopecia
  4. amenorrhea
  5. anaphylactoid reactions
  6. angioedema
  7. anorexia
  8. anxiety
  9. arthralgia
  10. asthenia
  11. back pain
  12. bleeding
  13. breast discharge
  14. breast enlargement
  15. bronchospasm
  16. constipation
  17. cough
  18. depression
  19. diarrhea
  20. dizziness
  21. drowsiness
  22. dysmenorrhea
  23. dyspepsia
  24. dysuria
  25. edema
  26. emotional lability
  27. erythema
  28. fatigue
  29. fever
  30. flatulence
  31. gastritis
  32. headache
  33. hematoma
  34. hot flashes
  35. hypertension
  36. hypertrichosis
  37. infection
  38. injection site reaction
  39. insomnia
  40. leukorrhea
  41. libido decrease
  42. mastalgia
  43. melasma
  44. menstrual irregularity
  45. migraine
  46. myalgia
  47. nausea
  48. paresthesias
  49. pelvic pain
  50. pharyngitis
  51. pruritus
  52. pulmonary embolism
  53. rash
  54. rhinitis
  55. seizures
  56. sinusitis
  57. stroke
  58. thrombosis
  59. urticaria
  60. vaginal bleeding
  61. vaginal discharge
  62. vaginal irritation
  63. vaginitis
  64. vomiting
  65. weight gain
  66. weight loss

Monitoring Parameters

  • pap smear
  • pelvic exam
  • pregnancy testing
  • weight

Contraindications

  • breast cancer
  • breast-feeding
  • cerebrovascular disease
  • cervical cancer
  • children
  • contact lenses
  • coronary artery disease
  • depression
  • diabetes mellitus
  • ectopic pregnancy
  • edema
  • gallbladder disease
  • geriatric
  • heart failure
  • hepatic disease
  • hepatocellular cancer
  • human immunodeficiency virus (HIV) infection
  • hyperlipidemia
  • hypertension
  • infants
  • intramuscular administration
  • jaundice
  • migraine
  • myocardial infarction
  • neonates
  • obesity
  • ovarian cyst
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder
  • stroke
  • surgery
  • thromboembolic disease
  • thrombophlebitis
  • tobacco smoking
  • vaginal bleeding

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetohexamide
  • Acitretin
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Armodafinil
  • Artemether; Lumefantrine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bexarotene
  • Boceprevir
  • Bosentan
  • Brigatinib
  • Bromocriptine
  • Butabarbital
  • Canagliflozin; Metformin
  • Carbamazepine
  • Cenobamate
  • Chloramphenicol
  • Chlorpropamide
  • Cimetidine
  • Ciprofloxacin
  • Clarithromycin
  • Clobazam
  • Cobicistat
  • Cyclosporine
  • Dabrafenib
  • Danazol
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Diltiazem
  • Dronedarone
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enasidenib
  • Encorafenib
  • Enzalutamide
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Felbamate
  • Fluconazole
  • Fluvoxamine
  • Fosamprenavir
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • grapefruit juice
  • Griseofulvin
  • Hydantoins
  • Idelalisib
  • Imatinib
  • Incretin Mimetics
  • Indinavir
  • Insulins
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Lamotrigine
  • Lesinurad
  • Lesinurad; Allopurinol
  • Linagliptin
  • Linagliptin; Metformin
  • Lopinavir; Ritonavir
  • Lorlatinib
  • Lumacaftor; Ivacaftor
  • Meglitinides
  • Mephobarbital
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methohexital
  • Mifepristone
  • Modafinil
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Nicardipine
  • Nilotinib
  • Octreotide
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Oxcarbazepine
  • Pegaspargase
  • Pentobarbital
  • Pexidartinib
  • Phenobarbital
  • Phentermine; Topiramate
  • Pitolisant
  • Posaconazole
  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Primidone
  • Quinine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifamycins
  • Rifapentine
  • Ritonavir
  • Rufinamide
  • Saquinavir
  • Saxagliptin
  • Secobarbital
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • St. John’s Wort, Hypericum perforatum
  • Sugammadex
  • Sulfonylureas
  • Tazemetostat
  • Telithromycin
  • Thalidomide
  • Thiopental
  • Tipranavir
  • Tolazamide
  • Tolbutamide
  • Topiramate
  • Trandolapril; Verapamil
  • Ulipristal
  • Verapamil
  • Voriconazole
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