Encorafenib

Encorafenib Brand Name– BRAFTOVI

What is Encorafenib

Encorafenib is a kinase inhibitor that inhibits cell growth in BRAF V600 mutation-positive tumors.

Using an FDA-approved test, confirm the presence of the BRAF V600 mutation in tumor specimens prior to initiation of treatment.

Encorafenib is indicated in combination with binimetinib for the treatment of BRAF V600E or V600K mutation-positive unresectable or metastatic melanoma, and in combination with cetuximab for the treatement of BRAF V600 mutated metastatic colorectal cancer.

It is not indicated for the treatment of BRAF wild-type melanoma or colorectal cancer.

New primary cutaneous malignancies and QT prolongation have been reported with encorafenib use.

Indications

• colorectal cancer
• malignant melanoma

Side Effects

1. abdominal pain
2. acneiform rash
3. alopecia
4. anemia
5. anorexia
6. anorexia
7. arthralgia
8. arthralgia
9. back pain
10. bleeding
11. bleeding
12. constipation
13. diarrhea
14. diarrhea
15. dizziness
16. dizziness
17. dysgeusia
18. elevated hepatic enzymes
19. elevated hepatic enzymes
20. epistaxis
21. erythema
22. fatigue
23. fatigue
24. fever
25. fever
26. GI bleeding
27. headache
28. headache
29. hyperglycemia
30. hyperglycemia
31. hyperkeratosis
32. hyperkeratosis
33. hypermagnesemia
34. hypermagnesemia
35. hypokalemia
36. hypokalemia
37. hypomagnesemia
38. hyponatremia
39. hyponatremia
40. insomnia
41. intracranial bleeding
42. iritis
43. leukopenia
44. lymphopenia
45. lymphopenia
46. myopathy
47. myopathy
48. nausea
49. nausea
50. nephrotoxicity
51. neutropenia
52. neutropenia
53. new primary malignancy
54. palmar-plantar erythrodysesthesia (hand and foot syndrome)
55. pancreatitis
56. panniculitis
57. paresis
58. peripheral neuropathy
59. peripheral neuropathy
60. prolonged bleeding time
61. prolonged bleeding time
62. pruritus
63. pruritus
64. QT prolongation
65. rash
66. rash
67. uveitis
68. vomiting
69. vomiting
70. xerosis

Monitoring Parameters

• ophthalmologic exam
• pregnancy testing
• serum electrolytes
• skin cancer screening exam

Contraindications

• apheresis
• AV block
• bradycardia
• breast-feeding
• cardiomyopathy
• celiac disease
• contraception requirements
• electrolyte imbalance
• females
• fever
• geriatric
• heart failure
• human immunodeficiency virus (HIV) infection
• hyperparathyroidism
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypothermia
• hypothyroidism
• infertility
• iritis
• long QT syndrome
• myocardial infarction
• new primary malignancy
• pheochromocytoma
• pregnancy
• pregnancy testing
• QT prolongation
• reproductive risk
• rheumatoid arthritis
• sickle cell disease
• skin disease
• sleep deprivation
• stroke
• systemic lupus erythematosus (SLE)
• uveitis
• visual disturbance
• visual impairment

Interactions

• Acalabrutinib
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• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
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• Anagrelide
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