Encainide

Encainide Brand Name– Enkaid

What is Encainide

NOTE: This drug is discontinued in the US; however, it is available for compassionate use in patients previously receiving encainide.

Encainide is an orally administered class IC antiarrhythmic agent previously used in the treatment of documented life-threatening arrhythmias, nonsustained ventricular tachycardia, and frequent PVCs. It is similar to flecainide and moricizine.

The results of the Cardiac Arrhythmia Suppression Trial (CAST) indicate that the rates of nonfatal cardiac arrest and total mortality in patients with recent myocardial infarction, asymptomatic or symptomatic ventricular arrhythmias, and mild to moderate left ventricular dysfunction were significantly increased in patients who received encainide.

These implications led to the withdrawal of encainide from the U.S. market in 1991, although the manufacturer continued to make the drug available (compassionate use program) to those patients previously receiving encainide.

Encainide was originally approved by the FDA in December 1986.

Indications

  1. premature ventricular contractions (PVCs)
  2. ventricular tachycardia

For the treatment of premature ventricular contractions (PVCs), nonsustained ventricular tachycardia, or other life-threatening ventricular arrhythmias

Side Effects

  1. arrhythmia exacerbation
  2. dizziness
  3. dyspnea
  4. headache
  5. heart failure
  6. hyperglycemia
  7. insomnia
  8. nausea
  9. tinnitus
  10. ventricular fibrillation
  11. ventricular tachycardia
  12. visual impairment
  13. vomiting

Monitoring Parameters

  • blood glucose
  • ECG
  • serum creatinine/BUN
  • serum potassium

Contraindications

  • AV block
  • breast-feeding
  • bundle-branch block
  • cardiogenic shock
  • cardiomyopathy
  • diabetes mellitus
  • geriatric
  • heart failure
  • hepatic disease
  • hyperkalemia
  • hypokalemia
  • myocardial infarction
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • sick sinus syndrome
  • ventricular dysfunction

Interactions

  • Acebutolol
  • Acetaminophen; Propoxyphene
  • Amiodarone
  • Amlodipine; Celecoxib
  • Artemether; Lumefantrine
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Bendroflumethiazide; Nadolol
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Brimonidine; Timolol
  • Bupropion
  • Bupropion; Naltrexone
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Chlorpromazine
  • Cimetidine
  • Cinacalcet
  • Citalopram
  • Clozapine
  • Cobicistat
  • Colesevelam
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Diltiazem
  • Dofetilide
  • Dorzolamide; Timolol
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Escitalopram
  • Esmolol
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Ginger, Zingiber officinale
  • Haloperidol
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Imatinib
  • Labetalol
  • Lacosamide
  • Lopinavir; Ritonavir
  • Metoprolol
  • Mirabegron
  • Nadolol
  • Nebivolol
  • Nebivolol; Valsartan
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oritavancin
  • Paroxetine
  • Peginterferon Alfa-2b
  • Penbutolol
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Pindolol
  • Propoxyphene
  • Propranolol
  • Quinine
  • Ranolazine
  • Risperidone
  • Ritonavir
  • Rolapitant
  • Sertraline
  • Sotalol
  • Terbinafine
  • Tetracaine
  • Thioridazine
  • Timolol
  • Vemurafenib
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