Eltrombopag Brand Name– Promacta
What is Eltrombopag
Eltrombopag is an oral non-peptide thrombopoietin receptor agonist for the treatment of thrombocytopenia in patients with idiopathic thrombocytopenic purpura (ITP) and patients with chronic hepatitis C infection.
Eltrombopag is also indicated in patients with severe aplastic anemia.
Additionally, eltrombopag is under investigation for the treatment of thrombocytopenia from other causes, including chemotherapy-induced thrombocytopenia.
Indications
- aplastic anemia
- immune thrombocytopenic purpura (ITP)
- thrombocytopenia
For the treatment of thrombocytopenia in patients with chronic hepatitis C to allow the initiation and maintenance of interferon-based therapy
Side Effects
- abdominal pain
- alopecia
- anemia
- anorexia
- arthralgia
- ascites
- asthenia
- back pain
- bleeding
- cataracts
- chills
- cough
- dental pain
- diarrhea
- dizziness
- dyspnea
- ecchymosis
- elevated hepatic enzymes
- encephalopathy
- fatigue
- fever
- headache
- hepatic decompensation
- hepatotoxicity
- hyperbilirubinemia
- infection
- influenza
- insomnia
- muscle cramps
- myalgia
- nausea
- paresthesias
- peripheral edema
- pharyngitis
- pruritus
- rash
- renal failure (unspecified)
- rhinitis
- rhinorrhea
- skin hyperpigmentation
- thromboembolism
- thrombotic microangiopathy
- vomiting
Monitoring Parameters
- CBC
- LFTs
- serum bilirubin (total and direct)
Contraindications
- anticoagulant therapy
- Asian patients
- bleeding
- bone marrow suppression
- breast-feeding
- cataracts
- contraception requirements
- geriatric
- hepatic decompensation
- hepatic disease
- hepatitis C infection
- hepatotoxicity
- hypoalbuminemia
- neoplastic disease
- pregnancy
- renal impairment
- reproductive risk
- thromboembolic disease
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Alfentanil
- Aliskiren; Valsartan
- Alpelisib
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amlodipine; Atorvastatin
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin; Clarithromycin; Omeprazole
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Bempedoic Acid; Ezetimibe
- Benzhydrocodone; Acetaminophen
- Betrixaban
- Bivalirudin
- Bosentan
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Butabarbital
- Calcium
- Carbamazepine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Celecoxib
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Cimetidine
- Ciprofloxacin
- Citalopram
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Dabigatran
- Dalteparin
- Danaparoid
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Desirudin
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Edoxaban
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Eluxadoline
- Enoxaparin
- Esomeprazole; Naproxen
- Etodolac
- Ezetimibe
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Fenoprofen
- Fentanyl
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Flurbiprofen
- Fluvastatin
- Fluvoxamine
- Fondaparinux
- food
- Gemfibrozil
- Glecaprevir; Pibrentasvir
- Glyburide
- Glyburide; Metformin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Heparin
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Imatinib
- Indomethacin
- Iron
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lapatinib
- Lepirudin
- Letermovir
- Levorphanol
- Lopinavir; Ritonavir
- Magnesium
- Maraviroc
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Metformin; Repaglinide
- Methadone
- Methohexital
- Methotrexate
- Mexiletine
- Mitoxantrone
- Morphine
- Morphine; Naltrexone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nebivolol; Valsartan
- Niacin; Simvastatin
- Nonsteroidal antiinflammatory drugs
- Olmesartan
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Opiate Agonists
- Oxaprozin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paclitaxel
- Pazopanib
- Pentobarbital
- Pentosan
- Phenobarbital
- Piroxicam
- Pitavastatin
- Pravastatin
- Primidone
- Propoxyphene
- Quinine
- Remifentanil
- Repaglinide
- Revefenacin
- Rifampin
- Rimegepant
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Rosuvastatin
- Sacubitril; Valsartan
- Secobarbital
- Simvastatin
- Simvastatin; Sitagliptin
- Sodium Bicarbonate
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulindac
- Tacrine
- Talazoparib
- Teriflunomide
- Thiabendazole
- Thiopental
- Tinzaparin
- Tipranavir
- tobacco
- Tolmetin
- Topotecan
- Trimethoprim
- Ubrogepant
- Valdecoxib
- Valsartan
- Warfarin
- Zafirlukast
- Zileuton
- Zinc
- Zinc Salts