Donepezil Memantine

Donepezil Memantine Brand Name– Namzaric

What is Donepezil Memantine

Donepezil memantine is a fixed-dose combination product containing an acetylcholinesterase inhibitor (donepezil) and an NMDA receptor antagonist (extended-release memantine) indicated for the treatment of moderate to severe Alzheimer’s disease in patients who are already stabilized on both of the individual drugs or donepezil alone.

Donepezil memantine is a once-daily oral capsule that can be opened to allow sprinkling of the contents on food to ease administration in patients with difficulty swallowing.

Unlike other cholinesterase inhibitors, donepezil is considered a drug with a known risk of torsade de pointes (TdP), and the risk versus benefit of donepezil; memantine therapy should be determined in patients with risk factors for QT prolongation and TdP.

The FDA approved donepezil memantine (Namzaric) in December 2014.

Indications

  • Alzheimer’s disease

For the treatment of moderate to severe dementia associated with Alzheimer’s disease

Side Effects

  1. abdominal pain
  2. agitation
  3. agranulocytosis
  4. anorexia
  5. anxiety
  6. atopic dermatitis
  7. AV block
  8. back pain
  9. bradycardia
  10. chest pain (unspecified)
  11. cholecystitis
  12. confusion
  13. constipation
  14. dehydration
  15. depression
  16. diarrhea
  17. dizziness
  18. drowsiness
  19. ecchymosis
  20. emotional lability
  21. fever
  22. GI bleeding
  23. hallucinations
  24. headache
  25. heart failure
  26. hemolytic anemia
  27. hepatitis
  28. hostility
  29. hyperlipidemia
  30. hypertension
  31. hyponatremia
  32. hypotension
  33. infection
  34. influenza
  35. insomnia
  36. leukopenia
  37. muscle cramps
  38. nausea
  39. neuroleptic malignant syndrome
  40. neutropenia
  41. pancreatitis
  42. pancytopenia
  43. peptic ulcer
  44. QT prolongation
  45. rash
  46. renal failure (unspecified)
  47. rhabdomyolysis
  48. seizures
  49. Stevens-Johnson syndrome
  50. suicidal ideation
  51. syncope
  52. thrombocytopenia
  53. thrombotic thrombocytopenic purpura (TTP)
  54. torsade de pointes
  55. toxic epidermal necrolysis
  56. urinary incontinence
  57. vomiting
  58. weight gain

Monitoring Parameters

  • neurologic function
  • serum creatinine
  • weight

Contraindications

  • alcoholism
  • asthma
  • AV block
  • bladder obstruction
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • coronary artery disease
  • diabetes mellitus
  • diarrhea
  • females
  • geriatric
  • GI bleeding
  • GI disease
  • heart failure
  • hepatic disease
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypotension
  • infants
  • long QT syndrome
  • malnutrition
  • myocardial infarction
  • neonates
  • peptic ulcer disease
  • pregnancy
  • pulmonary disease
  • QT prolongation
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder
  • seizures
  • sick sinus syndrome
  • surgery
  • syncope
  • thyroid disease
  • urinary tract infection (UTI)
  • vomiting

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