Donepezil Memantine Brand Name– Namzaric
What is Donepezil Memantine
Donepezil memantine is a fixed-dose combination product containing an acetylcholinesterase inhibitor (donepezil) and an NMDA receptor antagonist (extended-release memantine) indicated for the treatment of moderate to severe Alzheimer’s disease in patients who are already stabilized on both of the individual drugs or donepezil alone.
Donepezil memantine is a once-daily oral capsule that can be opened to allow sprinkling of the contents on food to ease administration in patients with difficulty swallowing.
Unlike other cholinesterase inhibitors, donepezil is considered a drug with a known risk of torsade de pointes (TdP), and the risk versus benefit of donepezil; memantine therapy should be determined in patients with risk factors for QT prolongation and TdP.
The FDA approved donepezil memantine (Namzaric) in December 2014.
Indications
- Alzheimer’s disease
For the treatment of moderate to severe dementia associated with Alzheimer’s disease
Side Effects
- abdominal pain
- agitation
- agranulocytosis
- anorexia
- anxiety
- atopic dermatitis
- AV block
- back pain
- bradycardia
- chest pain (unspecified)
- cholecystitis
- confusion
- constipation
- dehydration
- depression
- diarrhea
- dizziness
- drowsiness
- ecchymosis
- emotional lability
- fever
- GI bleeding
- hallucinations
- headache
- heart failure
- hemolytic anemia
- hepatitis
- hostility
- hyperlipidemia
- hypertension
- hyponatremia
- hypotension
- infection
- influenza
- insomnia
- leukopenia
- muscle cramps
- nausea
- neuroleptic malignant syndrome
- neutropenia
- pancreatitis
- pancytopenia
- peptic ulcer
- QT prolongation
- rash
- renal failure (unspecified)
- rhabdomyolysis
- seizures
- Stevens-Johnson syndrome
- suicidal ideation
- syncope
- thrombocytopenia
- thrombotic thrombocytopenic purpura (TTP)
- torsade de pointes
- toxic epidermal necrolysis
- urinary incontinence
- vomiting
- weight gain
Monitoring Parameters
- neurologic function
- serum creatinine
- weight
Contraindications
- alcoholism
- asthma
- AV block
- bladder obstruction
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- coronary artery disease
- diabetes mellitus
- diarrhea
- females
- geriatric
- GI bleeding
- GI disease
- heart failure
- hepatic disease
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypotension
- infants
- long QT syndrome
- malnutrition
- myocardial infarction
- neonates
- peptic ulcer disease
- pregnancy
- pulmonary disease
- QT prolongation
- renal disease
- renal failure
- renal impairment
- seizure disorder
- seizures
- sick sinus syndrome
- surgery
- syncope
- thyroid disease
- urinary tract infection (UTI)
- vomiting
Interactions
- Abacavir; Dolutegravir; Lamivudine
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- Acetaminophen; Dextromethorphan
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