Do the selective COX2 inhibitors have a lower risk for gastrointestinal toxicity

Do the selective COX2 inhibitors have a lower risk for gastrointestinal toxicity compared to the traditional nonsteroidal antiinflammatory drugs?

Yes. The COX2 inhibitors were associated with a lower incidence of symptomatic ulcers compared with traditional NSAIDs at standard doses. The decrease in upper GI toxicity was strongest among patients not taking aspirin concomitantly.

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