Risk factors for aminoglycoside kidney toxicity

What are the common risk factors for aminoglycoside kidney toxicity?

Dose and duration of therapy, advanced age, use of other nephrotoxic agents (cyclosporine, tacrolimus, vancomycin), sepsis, hypotension, dehydration, and intravenous radiologic contrast medium have been reported as important risk factors in the development of aminoglycoside-induced nephrotoxicity.

However, when confounding factors are adjusted using multivariate analysis, only dose, duration, advanced age, and baseline creatinine level have been associated with nephrotoxicity.

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