Diphenhydramine Naproxen Brand Name– Aleve PM
What is Diphenhydramine Naproxen
Diphenhydramine naproxen is an oral combination product of a sedating antihistamine and a nonsteroidal anti-inflammatory drug (NSAID) indicated for relief of occasional sleeplessness when associated with minor aches and pains.
All NSAIDs, including naproxen, cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and GI perforation of the esophagus, stomach, small intestine, or large intestine and are associated with an increased risk of serious cardiovascular (CV) thromboembolism, including myocardial infarction or stroke.
Use the lowest effective dose for the shortest possible duration; the increase in CV risk has been most consistently observed at higher doses.
Indications
- insomnia
For the treatment of occasional insomnia when associated with minor aches and pains
Side Effects
- abdominal pain
- acne vulgaris
- agranulocytosis
- alopecia
- amblyopia
- amnesia
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- anxiety
- aplastic anemia
- appetite stimulation
- arrhythmia exacerbation
- arthralgia
- aseptic meningitis
- asthenia
- atopic dermatitis
- azotemia
- back pain
- bleeding
- blurred vision
- bone fractures
- bone pain
- bronchospasm
- bullous rash
- bundle-branch block
- chest pain (unspecified)
- chills
- cholecystitis
- cholelithiasis
- colitis
- coma
- confusion
- conjunctivitis
- constipation
- contact dermatitis
- corneal opacification
- cough
- cystitis
- dehydration
- depression
- diaphoresis
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysarthria
- dysmenorrhea
- dyspepsia
- dysphagia
- dyspnea
- dysuria
- ecchymosis
- eczema vaccinatum
- edema
- elevated hepatic enzymes
- emotional lability
- eosinophilia
- epistaxis
- eructation
- erythema multiforme
- erythema nodosum
- esophageal stricture
- esophageal ulceration
- esophagitis
- euphoria
- exfoliative dermatitis
- fatigue
- fever
- flank pain
- flatulence
- gastritis
- GI bleeding
- GI perforation
- glomerulonephritis
- glossitis
- glycosuria
- hallucinations
- headache
- hearing loss
- heart failure
- hematemesis
- hematuria
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hepatomegaly
- hypercholesterolemia
- hyperglycemia
- hyperhidrosis
- hyperkalemia
- hypertension
- hypertonia
- hyperuricemia
- hypoglycemia
- hypokalemia
- hyponatremia
- hypotension
- impaired cognition
- increased urinary frequency
- infection
- infertility
- influenza
- insomnia
- interstitial nephritis
- irritability
- jaundice
- keratoconjunctivitis
- lacrimation
- leukopenia
- lichen planus-like eruption
- lupus-like symptoms
- lymphadenopathy
- malaise
- melena
- menorrhagia
- metabolic alkalosis
- migraine
- muscle cramps
- muscle paralysis
- myalgia
- myasthenia
- mydriasis
- myocardial infarction
- nasal congestion
- nausea
- nephrotic syndrome
- neuritis
- nocturia
- ocular pain
- odynophagia
- oliguria
- optic neuritis
- oral ulceration
- palpitations
- pancreatitis
- pancytopenia
- papilledema
- paresthesias
- pelvic pain
- peptic ulcer
- peripheral edema
- peripheral vasodilation
- pharyngitis
- phlebitis
- photosensitivity
- platelet dysfunction
- pneumonitis
- polyuria
- prolonged bleeding time
- proteinuria
- pruritus
- pseudoporphyria
- ptosis
- pulmonary edema
- purpura
- pyrosis (heartburn)
- pyuria
- rash
- renal failure (unspecified)
- renal papillary necrosis
- respiratory depression
- restlessness
- rhinitis
- seizures
- sinus tachycardia
- sinusitis
- skin necrosis
- skin ulcer
- splenomegaly
- Stevens-Johnson syndrome
- stomatitis
- stroke
- subdural hematoma
- syncope
- thrombocytopenia
- thromboembolism
- tinnitus
- toxic epidermal necrolysis
- tremor
- urinary incontinence
- urinary retention
- urticaria
- vaginitis
- vasculitis
- vertigo
- visual impairment
- vomiting
- weakness
- weight gain
- weight loss
- wheezing
- xerophthalmia
- xerosis
- xerostomia
Monitoring Parameters
- CBC
- LFTs
- serum creatinine/BUN
Contraindications
- acute bronchospasm
- acute myocardial infarction
- adrenal insufficiency
- anemia
- angina
- anticholinergic medications
- anticoagulant therapy
- asthma
- bladder obstruction
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- cerebrovascular disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- coagulopathy
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- corticosteroid therapy
- dehydration
- driving or operating machinery
- ethanol ingestion
- geriatric
- GI bleeding
- GI obstruction
- GI perforation
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- hypoalbuminemia
- hypovolemia
- increased intraocular pressure
- infants
- infertility
- labor
- laboratory test interference
- myocardial infarction
- myocardial infarction or stroke
- nasal polyps
- neonates
- NSAID hypersensitivity
- obstetric delivery
- peptic ulcer disease
- peripheral vascular disease
- pregnancy
- prostatic hypertrophy
- renal disease
- renal failure
- renal impairment
- reproductive risk
- salicylate hypersensitivity
- serious rash
- sodium restriction
- stroke
- tachycardia
- thromboembolism
- tobacco smoking
- urticaria
Interactions
- Abciximab
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Codeine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acetohexamide
- Acyclovir
- Adefovir
- Aldesleukin, IL-2
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alosetron
- Alpha-blockers
- Alteplase
- Altretamine
- Amantadine
- Ambenonium Chloride
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Aminolevulinic Acid
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
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- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
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- Benazepril
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- Bendamustine
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- Benzodiazepines
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- Benzphetamine
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- Bisoprolol
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- Bisphosphonates
- Bivalirudin
- Bleomycin
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
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- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
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- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Carmustine, BCNU
- Carteolol
- Carvedilol
- Cefotaxime
- Celecoxib
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlorambucil
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- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
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- Codeine; Guaifenesin
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- Colchicine; Probenecid
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- COMT inhibitors
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- Dextromethorphan; Promethazine
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- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Dipyridamole
- Disopyramide
- Docetaxel
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- Donepezil; Memantine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dorzolamide; Timolol
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- Dronabinol
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- Droperidol
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Drotrecogin Alfa
- Duloxetine
- Dutasteride; Tamsulosin
- Edoxaban
- Edrophonium
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enoxaparin
- Entacapone
- Entecavir
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
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- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Esmolol
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- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethotoin
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- Etomidate
- Ezogabine
- Famotidine; Ibuprofen
- Fenfluramine
- Fenofibric Acid
- Fenoldopam
- Fenoprofen
- Fentanyl
- Flavocoxid, Flavocoxid; Citrated Zinc Bisglycinate
- Flibanserin
- Floxuridine
- Fludarabine
- Fludrocortisone
- Flunisolide
- Fluorouracil, 5-FU
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- food
- Formoterol; Mometasone
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Fospropofol
- Furosemide
- Gabapentin
- Gadoterate meglumine
- Galantamine
- Gallium Ga 68 Dotatate
- Ganciclovir
- Garlic, Allium sativum
- Gemfibrozil
- Gentamicin
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Gold
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanabenz
- Guanfacine
- H2-blockers
- Halogenated Anesthetics
- Haloperidol
- Heparin
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydromorphone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibuprofen
- Ibuprofen lysine
- Ibuprofen; Oxycodone
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- Iloperidone
- Iloprost
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- Indapamide
- Indomethacin
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- Iodipamide Meglumine
- Iohexol
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- Irbesartan
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- Ivacaftor
- Ixabepilone
- Kanamycin
- Ketamine
- Ketoprofen
- Ketorolac
- Labetalol
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- Lasmiditan
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- Lemborexant
- Lepirudin
- Levobetaxolol
- Levobunolol
- Levocetirizine
- Levomefolate
- Levomethadyl
- Levomilnacipran
- Levorphanol
- Lisinopril
- Lithium
- Lofexidine
- Lomustine, CCNU
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- Loratadine
- Loratadine; Pseudoephedrine
- Losartan
- Loxapine
- Luliconazole
- Lumacaftor; Ivacaftor
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- Lumateperone
- Lurasidone
- Macimorelin
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- Magnesium Salts
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- Mannitol
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- Mefenamic Acid
- Melatonin
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- Methohexital
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- Metoprolol
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- Propoxyphene
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- Quinidine
- Quinolones
- Ramelteon
- Ramipril
- Rasagiline
- Remifentanil
- Reserpine
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- Rituximab; Hyaluronidase
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- Rivastigmine
- Rolapitant
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- Ropinirole
- Rotigotine
- Sacubitril; Valsartan
- Safinamide
- Salicylates
- Salsalate
- Secobarbital
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- Sincalide
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- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Sotalol
- Spironolactone
- Streptokinase
- Streptomycin
- Streptozocin
- Sucralfate
- Sufentanil
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
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- tobacco
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- Trandolapril
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- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Triamcinolone
- Triamterene
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Trospium
- Urea
- Urokinase
- Valacyclovir
- Valganciclovir
- Valsartan
- Vancomycin
- Vasodilators
- Vemurafenib
- Venlafaxine
- Verteporfin
- Vigabatrin
- Vilazodone
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Vorinostat
- Vortioxetine
- Warfarin
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem
