Dimenhydrinate

Dimenhydrinate Brand Names

Dramamine | Dramamine Motion Sickness Relief | Driminate | TripTone

What is Dimenhydrinate

Dimenhydrinate is an oral and parenteral antihistaminic agent with antiemetic and antivertigo activity.

Dimenhydrinate is an ethanolamine-derivative sedating antihistamine (H1-blocker).

It is the chlorotheophylline salt of diphenhydramine (contains about 55% diphenhydramine and about 45% 8-chlorotheophylline). The active moiety of dimenhydrinate is diphenhydramine.

Dimenhydrinate is used to prevent and treat the nausea, vomiting, dizziness, or vertigo associated with motion sickness and non-prescription oral products are marketed for this purpose.

The drug has also been used to treat hyperemesis gravidarum.

Dimenhydrinate was first marketed in 1949, which was prior to the modern FDA drug approval process.

Indications

1. hyperemesis gravidarum
2. Meniere’s syndrome
3. motion sickness
4. nausea/vomiting
5. nausea/vomiting prophylaxis
6. pregnancy-induced nausea/vomiting
7. vertigo

For nausea/vomiting, nausea/vomiting prophylaxis, and vertigo associated with motion sickness

Side Effects

1. anorexia
2. ataxia
3. AV block
4. blurred vision
5. confusion
6. constipation
7. delirium
8. diarrhea
9. dizziness
10. drowsiness
11. dyspepsia
12. dysuria
13. excitability
14. hallucinations
15. headache
16. hypotension
17. impaired cognition
18. insomnia
19. malaise
20. nasal dryness
21. nausea
22. palpitations
23. psychosis
24. restlessness
25. seizures
26. sinus tachycardia
27. tinnitus
28. urinary retention
29. urinary urgency
30. wheezing
31. xerophthalmia
32. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• anticholinergic medications
• appendicitis
• asthma
• benzyl alcohol hypersensitivity
• bladder obstruction
• breast-feeding
• bronchitis
• cardiac arrhythmias
• cardiac disease
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• CNS depression
• constipation
• contact lenses
• driving or operating machinery
• emphysema
• geriatric
• GI obstruction
• head trauma
• hepatic disease
• ileus
• infants
• labor
• neonates
• obstetric delivery
• phenylketonuria
• pregnancy
• prostatic hypertrophy
• pyloric stenosis
• salicylate hypersensitivity
• seizure disorder
• seizures
• tartrazine dye hypersensitivity
• urinary retention
• urinary tract obstruction

Interactions

• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Codeine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Alfentanil
• Alosetron
• Amantadine
• Ambenonium Chloride
• Aminoglycosides
• Amobarbital
• Amoxapine
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Anticholinergics
• Apomorphine
• Aripiprazole
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atracurium
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzphetamine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Buspirone
• Butabarbital
• Butorphanol
• Cannabidiol
• Capsaicin; Metaxalone
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carisoprodol
• Cenobamate
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpromazine
• Chlorzoxazone
• Cisatracurium
• Clobazam
• Clozapine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Cyclobenzaprine
• Dantrolene
• Daratumumab; Hyaluronidase
• Desloratadine
• Desloratadine; Pseudoephedrine
• Deutetrabenazine
• Dexmedetomidine
• Dextroamphetamine
• Dextromethorphan; Promethazine
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Disopyramide
• Donepezil
• Donepezil; Memantine
• Doxacurium
• Dronabinol
• Droperidol
• Entacapone
• Esketamine
• Eszopiclone
• Ethanol
• Etomidate
• Ezogabine
• Fentanyl
• Flibanserin
• Fluoxetine; Olanzapine
• Fluphenazine
• Fospropofol
• Gabapentin
• Galantamine
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Halogenated Anesthetics
• Haloperidol
• Heparin
• Homatropine; Hydrocodone
• Hyaluronidase
• Hyaluronidase, Recombinant; Immune Globulin
• Hydantoins
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Ibuprofen; Oxycodone
• Iloperidone
• Ipecac
• Isocarboxazid
• Ketamine
• Lasmiditan
• Lemborexant
• Levocetirizine
• Levomethadyl
• Levorphanol
• Lithium
• Lofexidine
• Loratadine
• Loratadine; Pseudoephedrine
• Loxapine
• Lumateperone
• Lurasidone
• Magnesium Salts
• Maprotiline
• Meclizine
• Melatonin
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Metaxalone
• Methadone
• Methamphetamine
• Methocarbamol
• Methohexital
• Metoclopramide
• Metyrapone
• Metyrosine
• Minocycline
• Mirtazapine
• Mitotane
• Mivacurium
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nalbuphine
• Nefazodone
• Neuromuscular blockers
• Olanzapine
• Opiate Agonists
• Orphenadrine
• Oxycodone
• Oxymorphone
• Paliperidone
• Pancuronium
• Paroxetine
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phenylephrine; Promethazine
• Pimozide
• Pitolisant
• Pramipexole
• Pregabalin
• Primidone
• Procarbazine
• Prochlorperazine
• Promethazine
• Propofol
• Propoxyphene
• Quetiapine
• Ramelteon
• Rapacuronium
• Rasagiline
• Remifentanil
• Risperidone
• Rituximab; Hyaluronidase
• Rivastigmine
• Rocuronium
• Ropinirole
• Safinamide
• Secobarbital
• Selegiline
• Sincalide
• Sodium Iodide
• Solifenacin
• Succinylcholine
• Sufentanil
• Suvorexant
• Tacrine
• Tapentadol
• Tasimelteon
• Teniposide
• Thalidomide
• Thiopental
• Thioridazine
• Thiothixene
• Tizanidine
• Tolcapone
• Tramadol
• Tranylcypromine
• Trastuzumab; Hyaluronidase
• Trazodone
• Tricyclic antidepressants
• Trifluoperazine
• Trimethobenzamide
• Trospium
• Tubocurarine
• Vecuronium
• Vigabatrin
• Vilazodone
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolpidem