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Dextromethorphan Guaifenesin Brand Names
Alka-Seltzer Plus Max Cough, Mucus & Congestion | Alka-Seltzer Plus Mucus and Congestion | AllFen DM | Altarussin DM | Ambi | Amibid DM | Aquabid DM | Aquatab DM | Atuss-12 DX | Bidex-A | Bidex-DM | Bidex-DMI | Cheracol D | Cofex-DM | Congesta DM | Coricidin HBP Chest Congetion and Cough | Delsym Children’s Cough + Chest Congestion DM | Delsym Cough + Chest Congestion DM | Delsym DM Children’s Cough + Chest Congestion | Dex-Tuss DM | Diabetic Tussin DM | DM/GUAI | Dometuss DM | Drituss DM | Duradex | Duradex Forte | Duraganidin DM | Duratuss DM | Duratuss DM 12 Tannate | ExeFen-DM | Extuss LA | Fenesin DM | Gani-Tuss DM NR | G-Bid DM TR | Genatuss DM | Geri_Tussin DM | GFN 600/DM 30 | Giltuss Children’s Cough & Chest | Giltuss Diabetic Cough & Cold | Giltuss HBP Cough & Chest Congestion | Guaiasorb DM | Guai-Dex | Guaidrine DM | Guaifenex DM | Guia-D | Guiadrine DX | Guiatuss DM | H-T Tussin | Humibid CS | Humibid DM | Hydro-Tussin DM | Iobid DM | Iophen DM-NR | Mindal DM | Mintab DM | Mucinex Children’s Cough | Mucinex Children’s Cough Mini-Melts | Mucinex DM | Mucinex Fast-Max DM Max | Muco-Fen DM | Mucus Children’s Cough | Mucus Relief | Mucus Relief DM | MucusRelief DM | Naldecon | Nalspan Senior DX | Nortuss EX | Orgadin-Tuss DM | PediaCare Cough & Congestion | Phlemex | Pulexn DM | Q-Bid DM | Q-Tussin DM | Relacon LAX | Respa-DM | Robafen DM | Robafen DM Clear | Robafen DM Max | Robitussin Adult Cough + Chest Congestion DM | Robitussin Adult Peak Cold | Robitussin Children’s Honey Cough & Congestion DM | Robitussin Cough + Congestion DM Maximum | Robitussin Cough and Congestion | Robitussin DM | Robitussin Honey Cough + Chest Congestion DM | Robitussin Pediatric Infant DM | Ru-Tuss-DM | Scot-Tussin Senior | Siltussin DM DAS | Siltussin-DM | Siltussin-DM Diabetic DAS-Na | Siltussin-DM Diabetic DAS-Na Maximum Strength | Simuc-DM | Sudal DM | Su-Tuss DM | Touro DM | Triaminic Cough & Congestion | TRISPEC DMX | Tussi-Bid | Tussiden DM | Tussidin DM NR | Tussi-Organidin DM NR | Vicks DayQuil Mucus Control DM | Vicks DayQuil Nature Fusion | Vicks Formula 44 | Vicks Formula 44E | Vicks Nature Fusion Cough & Chest Congestion | Z-Cof LA | Z-Cof LAX | Zotex DMX
What is Dextromethorphan Guaifenesin
Dextromethorphan and guaifenesin are used together in oral preparations to relieve coughing due to minor throat and bronchial irritation as may occur with the common cold.
Dextromethorphan is a non-opioid drug used as an antitussive.
Although it is related to the opiate agonists (dextromethorphan is the methyl ether of the d-isomer of the codeine analog levorphanol), dextromethorphan does not exhibit typical opiate agonist characteristics.
Dextromethorphan is useful in treating chronic, nonproductive cough, but it has no expectorant activity.
When ingested at recommended dosage levels for intended purposes, dextromethorphan is generally regarded as a safe and effective cough suppressant; however, the evidence for the drug’s utility for suppressing cough due to upper respiratory infection (URI) is not robust.
Guaifenesin is an expectorant that loosens and thins phlegm and bronchial secretions to ease expectoration.
Despite its long history of use since the 1950’s, the efficacy of guaifenesin has only recently been substantiated.
Guaifenesin is used for dry, nonproductive cough when there is the presence of tenacious mucus and mucus plugs.
The results of a few studies have favored active treatment with guaifenesin over placebo in treating productive cough due to upper respiratory illness (URI) and patients often subjectively report benefit to use.
Multiple formulations of the dextromethorphan; guaifenesin combination are available in both non-prescription (OTC) and prescription-only formulations.
Indications
- cough
For the temporary relief of cough, especially non-productive cough, due to minor throat and bronchial irritation such as may occur with the common cold
Side Effects
- abdominal pain
- confusion
- dizziness
- drowsiness
- dysarthria
- hallucinations
- headache
- irritability
- nausea
- nephrolithiasis
- rash
- respiratory depression
- restlessness
- seizures
- serotonin syndrome
- urticaria
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- asthma
- breast-feeding
- bronchitis
- children
- driving or operating machinery
- emphysema
- fever
- geriatric
- headache
- hepatic disease
- infants
- MAOI therapy
- pregnancy
- tobacco smoking
- vomiting
Interactions
- Abiraterone
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Codeine
- Alfentanil
- Amiodarone
- Amlodipine; Celecoxib
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Carisoprodol; Codeine
- Atazanavir; Cobicistat
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Buprenorphine
- Buprenorphine; Naloxone
- Celecoxib
- Chlorpheniramine; Codeine
- Cinacalcet
- Citalopram
- Clobazam
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Dacomitinib
- Darifenacin
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Delavirdine
- Desvenlafaxine
- Donepezil; Memantine
- Dronedarone
- Duloxetine
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Escitalopram
- Fedratinib
- Fentanyl
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Givosiran
- grapefruit juice
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Imatinib
- Isocarboxazid
- Lasmiditan
- Levomilnacipran
- Linezolid
- Lorcaserin
- Memantine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methylene Blue
- Milnacipran
- Mirabegron
- Mirtazapine
- Monoamine oxidase inhibitors
- Nefazodone
- Oritavancin
- Ozanimod
- Panobinostat
- Paroxetine
- Pazopanib
- Peginterferon Alfa-2b
- Phenelzine
- Procarbazine
- Propafenone
- Quinine
- Rasagiline
- Rolapitant
- Safinamide
- Selegiline
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- St. John’s Wort, Hypericum perforatum
- Tedizolid
- Terbinafine
- Tocilizumab
- Tranylcypromine
- Tricyclic antidepressants
- Vemurafenib
- Venlafaxine
- Vilazodone
- Vortioxetine
