Dextroamphetamine

Dextroamphetamine Brand Names

Dexedrine | Dexedrine Spansule | DextroStat | Liquadd | ProCentra | Zenzedi

What is Dextroamphetamine

Dextroamphetamine is an orally administered central nervous system agent. It is the d-isomer of amphetamine and is twice as potent a CNS stimulator on a weight basis than racemic amphetamine.

Dextroamphetamine also has greater CNS-stimulating activity than epinephrine or other catecholamines.

Clinical uses include the treatment of narcolepsy and attention-deficit hyperactivity disorder. Stimulants are considered first-line therapy in the treatment of ADHD.

While dextroamphetamine is still used occasionally as an anorectic agent, many states in the US restrict its use for this purpose.

Dextroamphetamine was approved by the FDA in 1958.

An oral solution formulation was FDA-approved in January 2008.

Indications

1. attention-deficit hyperactivity disorder (ADHD)
2. hypothalamic obesity
3. narcolepsy
4. obesity

For the treatment of attention-deficit hyperactivity disorder (ADHD)

Side Effects

1. abdominal pain
2. agitation
3. alopecia
4. anaphylactoid reactions
5. angioedema
6. anorexia
7. arrhythmia exacerbation
8. blurred vision
9. bradycardia
10. cardiac arrest
11. cardiomyopathy
12. chest pain (unspecified)
13. coma
14. constipation
15. delirium
16. diarrhea
17. dizziness
18. dysgeusia
19. dyskinesia
20. dyspepsia
21. emotional lability
22. euphoria
23. growth inhibition
24. hallucinations
25. headache
26. hostility
27. hyperhidrosis
28. hyperreflexia
29. hypertension
30. hyperthermia
31. hypotension
32. impotence (erectile dysfunction)
33. insomnia
34. irritability
35. libido decrease
36. libido increase
37. mania
38. mydriasis
39. myocardial infarction
40. nausea
41. ocular hypertension
42. palpitations
43. peripheral vasoconstriction
44. photosensitivity
45. physiological dependence
46. priapism
47. psychological dependence
48. psychosis
49. rash
50. renal failure (unspecified)
51. restlessness
52. rhabdomyolysis
53. seizures
54. serotonin syndrome
55. sinus tachycardia
56. skin ulcer
57. Stevens-Johnson syndrome
58. stroke
59. supranormalization
60. syncope
61. tolerance
62. Tourette’s syndrome
63. toxic epidermal necrolysis
64. tremor
65. urticaria
66. visual impairment
67. vomiting
68. weight loss
69. withdrawal
70. xerostomia

Monitoring Parameters

• blood pressure
• growth rate
• heart rate
• weight

Contraindications

• abrupt discontinuation
• acute myocardial infarction
• alcoholism
• anorexia nervosa
• aortic stenosis
• arteriosclerosis
• bipolar disorder
• breast-feeding
• bulimia nervosa
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• children
• congenital heart disease
• coronary artery disease
• depression
• driving or operating machinery
• geriatric
• glaucoma
• growth inhibition
• heart failure
• hepatic disease
• hypercortisolism
• hypertension
• hyperthyroidism
• infants
• mania
• MAOI therapy
• myocardial infarction
• neonates
• obesity treatment
• peripheral vascular disease
• pregnancy
• prosthetic heart valves
• psychosis
• radiographic contrast administration
• Raynaud’s phenomenon
• renal impairment
• schizophrenia
• seizure disorder
• seizures
• stroke
• substance abuse
• suicidal ideation
• surgery
• tachycardia
• thyrotoxicosis
• tics
• Tourette’s syndrome
• valvular heart disease
• ventricular arrhythmias
• ventricular dysfunction
• visual disturbance

Dextroamphetamine is contraindicated for use in patients with known hypersensitivity or idiosyncrasy to the sympathomimetic amines or any component of these products.

Interactions

• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Tramadol
• Acetazolamide
• Aclidinium; Formoterol
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Alkalinizing Agents
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amantadine
• Ambrisentan
• Amifampridine
• Amiloride; Hydrochlorothiazide, HCTZ
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Ammonium Chloride
• Amoxapine
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Antacids
• Arformoterol
• Armodafinil
• Ascorbic Acid, Vitamin C
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azilsartan
• Azilsartan; Chlorthalidone
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Beta-blockers
• Betaxolol
• Bethanechol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Bretylium
• Brimonidine; Timolol
• Bromocriptine
• Budesonide; Formoterol
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Caffeine
• Caffeine; Ergotamine
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Cardiac glycosides
• Carteolol
• Carvedilol
• Chlorothiazide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Cimetidine
• Cinacalcet
• Citalopram
• Citric Acid; Potassium Citrate
• Citric Acid; Potassium Citrate; Sodium Citrate
• Citric Acid; Sodium Citrate
• Clevidipine
• Clobazam
• Clonazepam
• Clonidine
• Cocaine
• Colchicine
• Colchicine; Probenecid
• Dacomitinib
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Desvenlafaxine
• Dextromethorphan; Quinidine
• Diazepam
• Digitoxin
• Digoxin
• Dihydroergotamine
• Diltiazem
• Dipeptidyl Peptidase-4 Inhibitors
• Dorzolamide; Timolol
• Doxazosin
• Dronabinol
• Dulaglutide
• Duloxetine
• Dyphylline
• Dyphylline; Guaifenesin
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Eplerenone
• Epoprostenol
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Escitalopram
• Esketamine
• Eslicarbazepine
• Esmolol
• Ethanol
• Ethotoin
• Etomidate
• Exenatide
• Ezogabine
• Famotidine
• Famotidine; Ibuprofen
• Felbamate
• Felodipine
• Fentanyl
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• food
• Formoterol
• Formoterol; Mometasone
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Gabapentin
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• Green Tea
• Guanabenz
• Guanfacine
• H2-blockers
• Halothane
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibritumomab Tiuxetan
• Iloprost
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iobenguane I 131
• Irbesartan
• Isocarboxazid
• Isoflurane
• Isradipine
• Ketamine
• Labetalol
• Lacosamide
• Lamotrigine
• Lasmiditan
• Levalbuterol
• Levetiracetam
• Levobetaxolol
• Levobunolol
• Levodopa
• Levomilnacipran
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Linagliptin; Metformin
• Linezolid
• Liothyronine
• Liraglutide
• Lisinopril
• Lithium
• Lixisenatide
• Loop diuretics
• Lopinavir; Ritonavir
• Lorazepam
• Lorcaserin
• Losartan
• Loxapine
• Lurasidone
• Macitentan
• Magnesium Hydroxide
• Maprotiline
• Mecamylamine
• Meglitinides
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Metaproterenol
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methazolamide
• Methenamine
• Methenamine; Sodium Acid Phosphate
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methohexital
• Methyclothiazide
• Methyldopa
• Methylene Blue
• Methylergonovine
• Methysergide
• Metolazone
• Metoprolol
• Miglitol
• Milnacipran
• Mirtazapine
• Modafinil
• Moexipril
• Molindone
• Monoamine oxidase inhibitors
• Nabilone
• Nadolol
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nicardipine
• Nicotine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrates
• Nizatidine
• Non-Ionic Contrast Media
• Olmesartan
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Sodium Bicarbonate
• Paroxetine
• Penbutolol
• Pentobarbital
• Perampanel
• Pergolide
• Perindopril
• Perindopril; Amlodipine
• Phenelzine
• Phenobarbital
• Phenoxybenzamine
• Phentermine
• Phentermine; Topiramate
• Phentolamine
• Phenytoin
• Pindolol
• Pioglitazone
• Pirbuterol
• Potassium Bicarbonate
• Potassium Citrate
• Potassium-sparing diuretics
• Pramlintide
• Prazosin
• Pregabalin
• Primidone
• Procarbazine
• Propofol
• Propranolol
• Proton pump inhibitors
• Quinapril
• Quinidine
• Racepinephrine
• Ramipril
• Ranitidine
• Rasagiline
• Reserpine
• Riociguat
• Ritonavir
• Rosiglitazone
• Rufinamide
• Sacubitril; Valsartan
• Safinamide
• Salmeterol
• Sedating H1-blockers
• Selegiline
• Selexipag
• Semaglutide
• Serotonin norepinephrine reuptake inhibitors
• Serotonin-Receptor Agonists
• Sertraline
• Sevoflurane
• SGLT2 Inhibitors
• Sibutramine
• Sodium Bicarbonate
• Sodium Lactate
• Sodium Oxybate
• Solriamfetol
• Sotalol
• St. John’s Wort, Hypericum perforatum
• Succinimides
• Sulfonylureas
• Tedizolid
• Telmisartan
• Terazosin
• Terbutaline
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thiothixene
• Thyroid hormones
• Tiagabine
• Timolol
• Tipranavir
• Topiramate
• Tramadol
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
• Treprostinil
• Tricyclic antidepressants
• Tromethamine
• Umeclidinium; Vilanterol
• Valproic Acid, Divalproex Sodium
• Valsartan
• Vasodilators
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Vortioxetine
• Yohimbine
• Ziprasidone
• Zonisamide