Amphetamine and Dextroamphetamine

Amphetamine and Dextroamphetamine Brand Names

Adderall | Adderall XR | Mydayis

What is Amphetamine and Dextroamphetamine

Amphetamine and dextroamphetamine mixed salts are used in combination as an oral preparation to treat attention-deficit hyperactivity disorder (ADHD) or narcolepsy.

Stimulants are considered first-line agents in the treatment of ADHD.

Amphetamine- and methylphenidate-containing products are considered equally effective in the treatment of ADHD; patients who do not respond to one may respond to the other.

The most common adverse reactions associated with amphetamine use include anorexia, abdominal pain, irritability, restlessness, insomnia, emotional lability, and tachycardia.

Stimulants can induce or exacerbate psychiatric symptoms and should be used with caution in patients with a history of mania, psychosis, or substance abuse.

Due to the possibility of new or worsening adverse psychiatric events (e.g., psychosis, aggression), close monitoring is recommended in patients with pre-existing psychosis or bipolar disorder.

Stimulants have also been associated with sudden death in patients with structural cardiac abnormalities; patients with structural heart defects, cardiomyopathy, or heart-rhythm disturbances may be at risk for adverse cardiac events.

The American Heart Association recommends careful screening of all children and adolescents prior to initiating pharmacologic therapy for attention-deficit hyperactivity disorder (ADHD), including a detailed patient and family history and physical examination.

Indications

  • attention-deficit hyperactivity disorder (ADHD)
  • narcolepsy

Side Effects

  1. abdominal pain
  2. agitation
  3. alopecia
  4. anaphylactoid reactions
  5. angioedema
  6. anorexia
  7. anxiety
  8. arrhythmia exacerbation
  9. asthenia
  10. blurred vision
  11. bradycardia
  12. cardiomyopathy
  13. chest pain (unspecified)
  14. coma
  15. confusion
  16. constipation
  17. delirium
  18. dental caries
  19. depression
  20. diarrhea
  21. dizziness
  22. drowsiness
  23. dysgeusia
  24. dyskinesia
  25. dysmenorrhea
  26. dyspepsia
  27. dysphemia
  28. dysphoria
  29. dyspnea
  30. emotional lability
  31. euphoria
  32. fever
  33. formication
  34. growth inhibition
  35. hallucinations
  36. headache
  37. hostility
  38. hyperhidrosis
  39. hyperreflexia
  40. hypertension
  41. hyperthermia
  42. hypotension
  43. impotence (erectile dysfunction)
  44. infection
  45. insomnia
  46. irritability
  47. libido decrease
  48. libido increase
  49. mania
  50. mydriasis
  51. myocardial infarction
  52. nausea
  53. ocular hypertension
  54. palpitations
  55. paranoia
  56. paresthesias
  57. peripheral vasoconstriction
  58. photosensitivity
  59. physiological dependence
  60. priapism
  61. psychological dependence
  62. psychosis
  63. rash
  64. renal failure (unspecified)
  65. restlessness
  66. rhabdomyolysis
  67. seizures
  68. serotonin syndrome
  69. sinus tachycardia
  70. skin ulcer
  71. Stevens-Johnson syndrome
  72. stroke
  73. suicidal ideation
  74. supranormalization
  75. syncope
  76. tachypnea
  77. teeth grinding (bruxism)
  78. tolerance
  79. Tourette’s syndrome
  80. toxic epidermal necrolysis
  81. tremor
  82. urticaria
  83. visual impairment
  84. vomiting
  85. weight loss
  86. withdrawal
  87. xerostomia

Monitoring Parameters

  • blood pressure
  • growth rate
  • heart rate
  • weight

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • alcoholism
  • anorexia nervosa
  • aortic stenosis
  • arteriosclerosis
  • bipolar disorder
  • breast-feeding
  • bulimia nervosa
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • cerebrovascular disease
  • children
  • congenital heart disease
  • coronary artery disease
  • depression
  • driving or operating machinery
  • geriatric
  • glaucoma
  • growth inhibition
  • heart failure
  • hepatic disease
  • hypercortisolism
  • hypertension
  • hyperthyroidism
  • infants
  • mania
  • MAOI therapy
  • myocardial infarction
  • neonates
  • obesity treatment
  • peripheral vascular disease
  • pregnancy
  • prosthetic heart valves
  • psychosis
  • radiographic contrast administration
  • Raynaud’s phenomenon
  • renal failure
  • renal impairment
  • schizophrenia
  • seizure disorder
  • seizures
  • stroke
  • substance abuse
  • suicidal ideation
  • surgery
  • tachycardia
  • thyrotoxicosis
  • tics
  • Tourette’s syndrome
  • valvular heart disease
  • ventricular arrhythmias
  • ventricular dysfunction
  • visual disturbance

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Aclidinium; Formoterol
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alkalinizing Agents
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amantadine
  • Ambrisentan
  • Amifampridine
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Ammonium Chloride
  • Amoxapine
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Antacids
  • Arformoterol
  • Armodafinil
  • Ascorbic Acid, Vitamin C
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Beta-blockers
  • Betaxolol
  • Bethanechol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Bretylium
  • Brimonidine; Timolol
  • Bromocriptine
  • Budesonide; Formoterol
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Cardiac glycosides
  • Carteolol
  • Carvedilol
  • Chlorothiazide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Cimetidine
  • Cinacalcet
  • Citalopram
  • Citric Acid; Potassium Citrate
  • Citric Acid; Potassium Citrate; Sodium Citrate
  • Citric Acid; Sodium Citrate
  • Clevidipine
  • Clobazam
  • Clonazepam
  • Clonidine
  • Cocaine
  • Colchicine
  • Colchicine; Probenecid
  • Dacomitinib
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Desvenlafaxine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Digitoxin
  • Digoxin
  • Dihydroergotamine
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Dorzolamide; Timolol
  • Doxazosin
  • Dronabinol
  • Dulaglutide
  • Duloxetine
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Escitalopram
  • Esketamine
  • Eslicarbazepine
  • Esmolol
  • Ethanol
  • Ethotoin
  • Etomidate
  • Exenatide
  • Ezogabine
  • Famotidine
  • Famotidine; Ibuprofen
  • Felbamate
  • Felodipine
  • Fentanyl
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • food
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Gabapentin
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guanabenz
  • Guanfacine
  • H2-blockers
  • Halothane
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Iloprost
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iobenguane I 131
  • Irbesartan
  • Isocarboxazid
  • Isoflurane
  • Isradipine
  • Ketamine
  • Labetalol
  • Lacosamide
  • Lamotrigine
  • Lasmiditan
  • Levalbuterol
  • Levetiracetam
  • Levobetaxolol
  • Levobunolol
  • Levodopa
  • Levomilnacipran
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lisinopril
  • Lithium
  • Lixisenatide
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Lorazepam
  • Lorcaserin
  • Losartan
  • Loxapine
  • Lurasidone
  • Macitentan
  • Magnesium Hydroxide
  • Maprotiline
  • Mecamylamine
  • Meglitinides
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Metaproterenol
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methazolamide
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methyclothiazide
  • Methyldopa
  • Methylene Blue
  • Methylergonovine
  • Methysergide
  • Metolazone
  • Metoprolol
  • Miglitol
  • Milnacipran
  • Mirtazapine
  • Modafinil
  • Moexipril
  • Molindone
  • Monoamine oxidase inhibitors
  • Nabilone
  • Nadolol
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nicardipine
  • Nicotine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrates
  • Nizatidine
  • Non-Ionic Contrast Media
  • Olmesartan
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Sodium Bicarbonate
  • Ozanimod
  • Paroxetine
  • Penbutolol
  • Pentobarbital
  • Perampanel
  • Pergolide
  • Perindopril
  • Perindopril; Amlodipine
  • Phenelzine
  • Phenobarbital
  • Phenoxybenzamine
  • Phentermine
  • Phentermine; Topiramate
  • Phentolamine
  • Phenytoin
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Potassium Bicarbonate
  • Potassium Citrate
  • Potassium-sparing diuretics
  • Pramlintide
  • Prazosin
  • Pregabalin
  • Primidone
  • Procarbazine
  • Propofol
  • Propranolol
  • Proton pump inhibitors
  • Quinapril
  • Quinidine
  • Racepinephrine
  • Ramipril
  • Ranitidine
  • Rasagiline
  • Remifentanil
  • Reserpine
  • Riociguat
  • Ritonavir
  • Rosiglitazone
  • Rufinamide
  • Sacubitril; Valsartan
  • Safinamide
  • Salmeterol
  • Sedating H1-blockers
  • Selegiline
  • Selexipag
  • Semaglutide
  • Serotonin norepinephrine reuptake inhibitors
  • Serotonin-Receptor Agonists
  • Sertraline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sibutramine
  • Sodium Bicarbonate
  • Sodium Lactate
  • Sodium Oxybate
  • Solriamfetol
  • Sotalol
  • St. John’s Wort, Hypericum perforatum
  • Succinimides
  • Sufentanil
  • Sulfonylureas
  • Tedizolid
  • Telmisartan
  • Terazosin
  • Terbutaline
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thiothixene
  • Thyroid hormones
  • Tiagabine
  • Timolol
  • Tipranavir
  • Topiramate
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Tricyclic antidepressants
  • Tromethamine
  • Umeclidinium; Vilanterol
  • Valproic Acid, Divalproex Sodium
  • Valsartan
  • Vasodilators
  • Venlafaxine
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Vortioxetine
  • Yohimbine
  • Ziprasidone
  • Zonisamide
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