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Desmopressin Brand Names
DDAVP | Minirin | Nocdurna | Noctiva | Stimate
What is Desmopressin
Desmopressin (1-deamino-8-D-arginine vasopressin) is a synthetic analog of arginine vasopressin (antidiuretic hormone, or ADH). Desmopressin is more potent and much longer acting than vasopressin.
Desmopressin is used to prevent or control symptoms of central diabetes insipidus (e.g., polyuria, polydipsia, and dehydration); it is not effective for nephrogenic diabetes insipidus.
The drug is also used to control polydipsia and polyuria that occur following pituitary surgery or head trauma, and the tablets are approved for managing primary nocturnal enuresis (PNE); however, the intranasal formulation is no longer indicated to treat PNE secondary to reports of hyponatremic-related seizures sometimes resulting in death.
An intranasal formulation and sublingual formulation are available for the treatment of nocturia due to nocturnal polyuria in adults; the oral formulation is not FDA approved for this indication.
Nasal preparations of desmopressin have about one-tenth the antidiuretic effect of an intravenously administered dose, but both forms are effective clinically.
The intranasal formulation has a longer duration of action; however, the oral formulation of desmopressin may be preferred for chronic therapy and for patients who do not tolerate intranasal administration.
Desmopressin is also indicated for the management of bleeding episodes in patients with mild to moderate hemophilia A or von Willebrand’s disease type 1.
Desmopressin can shorten or normalize bleeding time and correct platelet adhesion abnormalities in certain patients with bleeding disorders.
The FDA approved desmopressin in 1978.
Indications
- bleeding prophylaxis
- diabetes insipidus
- enuresis
- hemarthrosis
- hemophilia A
- hemorrhage
- nocturia
- sickle cell disease
- surgical bleeding
- uremic bleeding
- von Willebrand’s disease
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- asthenia
- back pain
- balanitis
- chills
- coma
- confusion
- conjunctivitis
- cough
- diarrhea
- dizziness
- dyspepsia
- elevated hepatic enzymes
- epistaxis
- flushing
- headache
- hypertension
- hyponatremia
- hypotension
- infertility
- injection site reaction
- lacrimation
- lethargy
- myocardial infarction
- nasal congestion
- nausea
- ocular pruritus
- oligospermia
- palpitations
- pharyngitis
- photophobia
- rhinalgia
- rhinitis
- seizures
- sinus tachycardia
- sneezing
- stroke
- thromboembolism
- thrombosis
- tolerance
- water intoxication
- xerostomia
Monitoring Parameters
- bleeding time
- factor VIII concentrations
- serum creatinine/BUN
- serum sodium
- urine osmolality
Contraindications
- angina
- breast-feeding
- cardiac disease
- children
- coronary artery disease
- cystic fibrosis
- diarrhea
- electrolyte imbalance
- fever
- geriatric
- heart failure
- hypertension
- hyponatremia
- increased intracranial pressure
- infection
- infertility
- nasal surgery
- nasal trauma
- pregnancy
- renal disease
- renal failure
- renal impairment
- thromboembolic disease
- urinary retention
- vomiting
- von Willebrand’s disease
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Guaifenesin; Phenylephrine
- Amlodipine; Celecoxib
- Articaine; Epinephrine
- Azelastine; Fluticasone
- Beclomethasone
- Betamethasone
- Brompheniramine; Carbetapentane; Phenylephrine
- Budesonide
- Budesonide; Formoterol
- Bumetanide
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Phenylephrine
- Celecoxib
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Phenylephrine
- Chlorpromazine
- Chlorpropamide
- Ciclesonide
- Cisplatin
- Codeine; Phenylephrine; Promethazine
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Deflazacort
- Demeclocycline
- Dexamethasone
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dopamine
- Epinephrine
- Esomeprazole; Naproxen
- Ethacrynic Acid
- Ethanol
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Fludrocortisone
- Flunisolide
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Furosemide
- Guaifenesin; Phenylephrine
- Heparin
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Ketoprofen
- Ketorolac
- Lamotrigine
- Lansoprazole; Naproxen
- Lithium
- Loop diuretics
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Methylprednisolone
- Mometasone
- Monoamine oxidase inhibitors
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Opiate Agonists
- Oxaprozin
- Oxybutynin
- Phenylephrine
- Phenylephrine; Promethazine
- Piroxicam
- Prednisolone
- Prednisone
- Prilocaine; Epinephrine
- Rofecoxib
- Selective serotonin reuptake inhibitors
- Sulindac
- Tolmetin
- Tolvaptan
- Torsemide
- Triamcinolone
- Tricyclic antidepressants
- Urea
- Valdecoxib
- Vasopressin, ADH
- Vincristine
- Vincristine Liposomal
