Desloratadine Pseudoephedrine Brand Name– Clarinex-D
What is Desloratadine Pseudoephedrine
Desloratadine and pseudoephedrine are used together in a prescription-only extended-release oral preparation to treat nasal congestion and seasonal allergic rhinitis.
Desloratadine is a non-sedating, potent, second-generation long-acting antihistamine (H1-blocker).
Desloratadine is the active metabolite of loratadine, with a relative potency of 10 to 20 times that of loratadine in vitro. Both loratadine and desloratadine are non-sedating; however, desloratadine does not cause QT prolongation, even when given in doses 4- to 9-times the recommended dose in adults.
Pseudoephedrine is a sympathomimetic agent that stimulates alpha1-adrenergic receptors in vascular smooth muscle.
This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency.
Desloratadine with pseudoephedrine products were first approved by the FDA in 2005.
Indications
- allergic rhinitis
- nasal congestion
For the treatment of seasonal allergic rhinitis and accompanying nasal congestion
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- anaphylactoid reactions
- angina
- anorexia
- anxiety
- appetite stimulation
- arrhythmia exacerbation
- chest pain (unspecified)
- dizziness
- drowsiness
- dyspnea
- dystonic reaction
- edema
- elevated hepatic enzymes
- fatigue
- hallucinations
- headache
- hepatitis
- hyperactivity
- hyperbilirubinemia
- hypertension
- hypotension
- insomnia
- involuntary movements
- myocardial infarction
- nausea
- ocular hypertension
- palpitations
- pharyngitis
- premature ventricular contractions (PVCs)
- pruritus
- psychosis
- rash
- restlessness
- seizures
- sinus tachycardia
- stroke
- supraventricular tachycardia (SVT)
- tremor
- urinary retention
- urticaria
- vomiting
- weakness
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- angina
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- closed-angle glaucoma
- coronary artery disease
- diabetes mellitus
- geriatric
- hepatic disease
- hypertension
- hyperthyroidism
- increased intraocular pressure
- infants
- MAOI therapy
- myocardial infarction
- neonates
- pregnancy
- prostatic hypertrophy
- renal failure
- renal impairment
- tachycardia
- urinary retention
Interactions
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetazolamide
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alkalinizing Agents
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Ammonium Chloride
- Amoxapine
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Arformoterol
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azilsartan; Chlorthalidone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Beta-blockers
- Betaxolol
- Bethanechol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bosentan
- Bretylium
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Bumetanide
- Bupropion
- Bupropion; Naltrexone
- Caffeine
- Caffeine; Ergotamine
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium-channel blockers
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Carteolol
- Carvedilol
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorcyclizine
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Clemastine
- Clevidipine
- Clonidine
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Cyclizine
- Cyproheptadine
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Digitoxin
- Digoxin
- Dihydroergotamine
- Diltiazem
- Dimenhydrinate
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dopamine
- Dorzolamide; Timolol
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droxidopa
- Dulaglutide
- Dyphylline
- Dyphylline; Guaifenesin
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Ephedrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esmolol
- Ethacrynic Acid
- Exenatide
- Felodipine
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol
- Formoterol; Mometasone
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Ginger, Zingiber officinale
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- Green Tea
- Guaifenesin; Phenylephrine
- Guanabenz
- Halogenated Anesthetics
- Haloperidol
- Heparin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Phenylephrine
- Hydroxyzine
- Iloprost
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Iobenguane I 131
- Isocarboxazid
- Isradipine
- Labetalol
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levocetirizine
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linagliptin; Metformin
- Linezolid
- Liothyronine
- Liraglutide
- Lisinopril
- Lixisenatide
- Loop diuretics
- Loratadine
- Loratadine; Pseudoephedrine
- Macitentan
- Maprotiline
- Mecamylamine
- Meclizine
- Meglitinides
- Metaproterenol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methazolamide
- Methyclothiazide
- Methyldopa
- Methylergonovine
- Methysergide
- Metolazone
- Metoprolol
- Midodrine
- Miglitol
- Moexipril
- Monoamine oxidase inhibitors
- Nabilone
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Nicardipine
- Nicotine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitrates
- Norepinephrine
- Ozanimod
- Penbutolol
- Pergolide
- Perindopril
- Perindopril; Amlodipine
- Phenelzine
- Phenylephrine
- Phenylephrine; Promethazine
- Pindolol
- Pioglitazone
- Pirbuterol
- Potassium-sparing diuretics
- Pramlintide
- Procarbazine
- Propranolol
- Quinapril
- Racepinephrine
- Ramipril
- Rasagiline
- Reserpine
- Riociguat
- Rosiglitazone
- Safinamide
- Salmeterol
- Sedating H1-blockers
- Selegiline
- Selexipag
- Semaglutide
- SGLT2 Inhibitors
- Sibutramine
- Sincalide
- Solriamfetol
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sulfonylureas
- Terbutaline
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiazolidinediones
- Thyroid hormones
- Timolol
- Torsemide
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Treprostinil
- Tricyclic antidepressants
- Triprolidine
- Umeclidinium; Vilanterol
- Vasodilators
- Vasopressors
- Verapamil
- Yohimbine
