Darifenacin Brand Name– Enablex
What is Darifenacin
Darifenacin hydrobromide is an oral competitive, selective M3 muscarinic receptor antagonist administered once daily to treat overactive bladder (OAB) and its symptoms in adults.
Both M2 and M3 receptors are located in the detrusor muscle; even though M2 receptors are much more prevalent, it appears that M3 receptors are more important in mediating direct detrusor contractions.
The M3 receptor is also involved in gastrointestinal smooth muscle function, salivary production, and iris sphincter function.
Treatment with darifenacin for OAB results in significant reductions in the frequency of urinary incontinence, reductions in the number of micturitions per day, and improvements in the frequency and severity of symptoms including urgency. In addition, darifenacin has been shown to be as effective as oxybutynin in reducing the incidence of incontinent episodes and symptoms of urgency.
When compared with oxybutynin, the incidence of dry mouth was found to be significantly lower with darifenacin (13% for darifenacin vs. 36% for oxybutynin, p less than 0.05).
Darifenacin was FDA-approved in 2004.
Indications
- overactive bladder (OAB)
- urinary incontinence
For the treatment of an overactive bladder (OAB) with symptoms of urinary frequency, urinary urgency, or urge-related urinary incontinence
Side Effects
- abdominal pain
- anaphylactoid reactions
- angioedema
- arthralgia
- asthenia
- back pain
- confusion
- constipation
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- erythema multiforme
- hallucinations
- headache
- hypertension
- nausea
- palpitations
- peripheral edema
- pharyngitis
- pruritus
- rash
- rhinitis
- urinary retention
- vaginitis
- vomiting
- weight gain
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- anticholinergic medications
- autonomic neuropathy
- bladder obstruction
- breast-feeding
- children
- closed-angle glaucoma
- constipation
- contact lenses
- driving or operating machinery
- gastroparesis
- geriatric
- GI obstruction
- hepatic disease
- history of angioedema
- ileus
- infants
- myasthenia gravis
- pregnancy
- prostatic hypertrophy
- pyloric stenosis
- ulcerative colitis
- urinary retention
- urinary tract obstruction
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Alfentanil
- Amantadine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Celecoxib
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Apalutamide
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
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- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
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- Benzhydrocodone; Acetaminophen
- Boceprevir
- Bosentan
- Brexpiprazole
- Brigatinib
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bumetanide
- Bupropion
- Bupropion; Naltrexone
- Butabarbital
- Caffeine
- Caffeine; Ergotamine
- Carbamazepine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Celecoxib
- Cenobamate
- Ceritinib
- Chloramphenicol
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cimetidine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clomipramine
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Dabrafenib
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desipramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Doxepin
- Doxorubicin
- Dronedarone
- Duloxetine
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Encorafenib
- Enzalutamide
- Escitalopram
- Ethacrynic Acid
- Fedratinib
- Fentanyl
- Fesoterodine
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fosamprenavir
- Fosphenytoin
- Furosemide
- grapefruit juice
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Idelalisib
- Imatinib
- Imipramine
- Indinavir
- Isavuconazonium
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lefamulin
- Letermovir
- Levodopa
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Maprotiline
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Methadone
- Methohexital
- Mexiletine
- Midazolam
- Mifepristone
- Mirabegron
- Mitotane
- Morphine
- Morphine; Naltrexone
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Nortriptyline
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Oritavancin
- Orphenadrine
- Oxycodone
- Oxymorphone
- Paroxetine
- Pazopanib
- Peginterferon Alfa-2b
- Pentobarbital
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenobarbital
- Phenytoin
- Pimozide
- Posaconazole
- Potassium-sparing diuretics
- Primidone
- Propafenone
- Propranolol
- Protriptyline
- Quetiapine
- Quinidine
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifamycins
- Ritonavir
- Rolapitant
- Saquinavir
- Secobarbital
- Sertraline
- Simeprevir
- Spironolactone
- Sufentanil
- Tamsulosin
- Tapentadol
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Terbinafine
- Thiopental
- Thioridazine
- Tipranavir
- Torsemide
- Tramadol
- Trandolapril; Verapamil
- Triamterene
- Tricyclic antidepressants
- Trimipramine
- Tucatinib
- Vemurafenib
- Verapamil
- Voriconazole
- Zafirlukast
- Zileuton