Daratumumab Hyaluronidase Brand Name– DARZALEX FASPRO
What is Daratumumab Hyaluronidase
Daratumumab hyaluronidase is a subcutaneously administered daratumumab product.
It is indicated for the treatment of multiple myeloma as monotherapy or in combination with lenalidomide/dexamethasone, bortezomib/dexamethasone, and bortezomib/melphalan/prednisone.
Because daratumumab binds to CD38 on red blood cells, it may interfere with the ability to determine a patient’s blood type and result in a false positive indirect antiglobulin test (Coombs test).
Additionally, daratumumab may interfere with the determination of complete response or disease progression in some patients.
Patients should have their blood typed and cross-matched prior to starting treatment.
Indications
- multiple myeloma
For the treatment of multiple myeloma
for the treatment of multiple myeloma in patients who have received at least 3 prior lines of therapy including a proteasome inhibitor (PI) and an immunomodulatory agent or who are double-refractory to a PI and an immunomodulatory agent
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- anemia
- anorexia
- anorexia
- antibody formation
- arthralgia
- asthenia
- atrial fibrillation
- back pain
- back pain
- bronchospasm
- chest pain (unspecified)
- chills
- chills
- constipation
- constipation
- cough
- cough
- dehydration
- diarrhea
- diarrhea
- dizziness
- dyspnea
- dyspnea
- erythema
- fatigue
- fatigue
- fever
- fever
- headache
- hepatitis B exacerbation
- hyperglycemia
- hyperglycemia
- hypertension
- hypertension
- hypocalcemia
- hypotension
- hypotension
- hypoxia
- infection
- infection
- influenza
- infusion-related reactions
- infusion-related reactions
- injection site reaction
- insomnia
- insomnia
- leukopenia
- leukopenia
- lymphopenia
- lymphopenia
- muscle cramps
- muscle cramps
- musculoskeletal pain
- nasal congestion
- nausea
- nausea
- neutropenia
- neutropenia
- pancreatitis
- paresthesias
- peripheral edema
- peripheral edema
- peripheral neuropathy
- peripheral neuropathy
- pharyngitis
- pruritus
- pulmonary edema
- rash
- rhinitis
- sinus tachycardia
- sinusitis
- throat irritation
- thrombocytopenia
- thrombocytopenia
- vomiting
- wheezing
Monitoring Parameters
- CBC with differential
Contraindications
- breast-feeding
- chronic obstructive pulmonary disease (COPD)
- contraception requirements
- geriatric
- hepatitis B exacerbation
- infection
- infusion-related reactions
- laboratory test interference
- neutropenia
- pregnancy
- reproductive risk
- thrombocytopenia
- vaccination
- viral infection
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Amide local anesthetics
- Aminosalicylate sodium, Aminosalicylic acid
- Articaine; Epinephrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Chloroprocaine
- Choline Salicylate; Magnesium Salicylate
- Cocaine
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Corticotropin, ACTH
- Cortisone
- Dienogest; Estradiol valerate
- Diethylstilbestrol, DES
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Ester local anesthetics
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Levobupivacaine
- Lidocaine
- Lidocaine; Prilocaine
- Magnesium Salicylate
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Palifermin
- Penicillamine
- Prilocaine
- Prilocaine; Epinephrine
- Procaine
- Ropivacaine
- Salicylates
- Salsalate
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Tetracaine
- Tuberculin Purified Protein Derivative, PPD