Danazol Brand Name– Danocrine
What is Danazol
Danazol is a synthetic steroid derived from ethisterone (ethinyl testosterone).
Danazol is antiestrogenic and weakly androgenic.
Danazol is used in the treatment of endometriosis, unless the process has advanced to the stage of surgical correction.
Danazol also is used in the palliative treatment of fibrocystic breast disease. Hereditary angioedema in both males and females also has been successfully treated with danazol.
Frequency of attacks can be limited by careful dose reduction after the initial response has been achieved.
Danazol was approved by the FDA in 1976.
Indications
- angioedema prophylaxis
- endometriosis
- fibrocystic breast disease
- immune thrombocytopenic purpura (ITP)
- mastalgia
- postcoital contraception
- premenstrual syndrome (PMS)
For the treatment of endometriosis
Side Effects
- acne vulgaris
- alopecia
- amenorrhea
- anovulation
- anxiety
- back pain
- breakthrough bleeding
- breast discharge
- carpal tunnel syndrome
- cataracts
- chills
- cholestasis
- constipation
- depression
- diaphoresis
- dizziness
- edema
- elevated hepatic enzymes
- emotional lability
- eosinophilia
- erythema multiforme
- erythrocytosis
- fatigue
- fever
- fluid retention
- flushing
- Guillain-Barre syndrome
- headache
- hematuria
- hepatoma
- hepatotoxicity
- hirsutism
- hoarseness
- hypercholesterolemia
- hyperglycemia
- jaundice
- leukocytosis
- leukopenia
- maculopapular rash
- menstrual irregularity
- muscle cramps
- myocardial infarction
- nasal congestion
- nausea
- oligospermia
- palpitations
- pancreatitis
- papilledema
- paresthesias
- peliosis hepatis
- pelvic pain
- petechiae
- pharyngitis
- photosensitivity
- pneumonitis
- polycythemia
- pruritus
- pseudotumor cerebri
- purpura
- seborrhea
- sinus tachycardia
- spermatogenesis inhibition
- Stevens-Johnson syndrome
- stroke
- teratogenesis
- thrombocytopenia
- thromboembolism
- thrombosis
- tremor
- urticaria
- vesicular rash
- visual impairment
- vomiting
- weakness
- weight gain
Monitoring Parameters
- LFTs
Contraindications
- breast cancer
- breast-feeding
- cardiac disease
- contraception requirements
- geriatric
- hepatic disease
- hepatotoxicity
- increased intracranial pressure
- jaundice
- migraine
- papilledema
- peliosis hepatis
- porphyria
- pregnancy
- pregnancy testing
- prostatic hypertrophy
- pseudotumor cerebri
- renal disease
- renal failure
- renal impairment
- seizure disorder
- stroke
- thromboembolic disease
- thromboembolism
- vaginal bleeding
Interactions
- Abarelix
- Abciximab
- Abemaciclib
- Acalabrutinib
- Acarbose
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Alprazolam
- Alteplase
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Anagrelide
- Antithrombin III
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
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- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
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- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
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